Detailed information
Bioinformatically predicted
Overview
| Name | cclA/cilC | Type | Machinery gene |
| Locus tag | EL096_RS06210 | Genome accession | NZ_LR134294 |
| Coordinates | 1178031..1178690 (+) | Length | 219 a.a. |
| NCBI ID | WP_000565001.1 | Uniprot ID | A0A0B7M7B9 |
| Organism | Streptococcus pneumoniae strain NCTC12977 | ||
| Function | processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake |
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Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Genomic island | 1168209..1201622 | 1178031..1178690 | within | 0 |
Gene organization within MGE regions
Location: 1168209..1201622
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EL096_RS06160 (NCTC12977_01201) | - | 1168209..1168979 (-) | 771 | WP_000229339.1 | sulfite exporter TauE/SafE family protein | - |
| EL096_RS06165 (NCTC12977_01202) | - | 1168994..1169842 (-) | 849 | WP_000782429.1 | formylglycine-generating enzyme family protein | - |
| EL096_RS06170 (NCTC12977_01203) | - | 1169839..1171314 (-) | 1476 | WP_050096564.1 | arylsulfatase | - |
| EL096_RS06175 (NCTC12977_01204) | - | 1171637..1172992 (-) | 1356 | WP_001865112.1 | PTS sugar transporter subunit IIC | - |
| EL096_RS06180 (NCTC12977_01205) | - | 1173002..1173319 (-) | 318 | WP_001005887.1 | PTS lactose/cellobiose transporter subunit IIA | - |
| EL096_RS06185 (NCTC12977_01206) | - | 1173336..1173653 (-) | 318 | WP_050221104.1 | PTS sugar transporter subunit IIB | - |
| EL096_RS06190 (NCTC12977_01207) | - | 1173668..1174564 (-) | 897 | WP_001865114.1 | hypothetical protein | - |
| EL096_RS06195 (NCTC12977_01208) | - | 1174567..1175829 (-) | 1263 | WP_000413342.1 | PTS sugar transporter subunit IIC | - |
| EL096_RS06200 (NCTC12977_01209) | - | 1176109..1177287 (+) | 1179 | WP_001865373.1 | ROK family transcriptional regulator | - |
| EL096_RS06205 (NCTC12977_01210) | - | 1177515..1177961 (-) | 447 | WP_000155432.1 | GNAT family N-acetyltransferase | - |
| EL096_RS06210 (NCTC12977_01211) | cclA/cilC | 1178031..1178690 (+) | 660 | WP_000565001.1 | prepilin peptidase | Machinery gene |
| EL096_RS06215 (NCTC12977_01212) | - | 1178742..1179893 (-) | 1152 | WP_001865397.1 | XRE family transcriptional regulator | - |
| EL096_RS06220 (NCTC12977_01213) | - | 1179908..1180639 (-) | 732 | WP_000934016.1 | hypothetical protein | - |
| EL096_RS06225 | - | 1180859..1180969 (+) | 111 | Protein_1187 | prepilin peptidase | - |
| EL096_RS06230 (NCTC12977_01214) | trpA | 1180941..1181717 (-) | 777 | WP_001127027.1 | tryptophan synthase subunit alpha | - |
| EL096_RS06235 (NCTC12977_01215) | trpB | 1181710..1182933 (-) | 1224 | WP_024477621.1 | tryptophan synthase subunit beta | - |
| EL096_RS06240 (NCTC12977_01216) | - | 1182911..1183510 (-) | 600 | WP_000169888.1 | phosphoribosylanthranilate isomerase | - |
| EL096_RS06245 (NCTC12977_01217) | trpC | 1183497..1184264 (-) | 768 | WP_000076548.1 | indole-3-glycerol phosphate synthase TrpC | - |
| EL096_RS06250 (NCTC12977_01218) | trpD | 1184261..1185265 (-) | 1005 | WP_000658682.1 | anthranilate phosphoribosyltransferase | - |
| EL096_RS06255 (NCTC12977_01219) | - | 1185276..1185842 (-) | 567 | WP_000601919.1 | aminodeoxychorismate/anthranilate synthase component II | - |
| EL096_RS06260 (NCTC12977_01220) | trpE | 1185839..1187200 (-) | 1362 | WP_000439654.1 | anthranilate synthase component I | - |
| EL096_RS11625 | - | 1187572..1187760 (-) | 189 | WP_185739684.1 | hypothetical protein | - |
| EL096_RS06270 (NCTC12977_01223) | - | 1188430..1189431 (-) | 1002 | WP_000789949.1 | LacI family DNA-binding transcriptional regulator | - |
| EL096_RS06275 (NCTC12977_01224) | - | 1189539..1189907 (-) | 369 | WP_000656286.1 | hypothetical protein | - |
| EL096_RS06280 (NCTC12977_01225) | - | 1190003..1190713 (-) | 711 | WP_000127552.1 | MgtC/SapB family protein | - |
| EL096_RS06285 (NCTC12977_01226) | - | 1190716..1192407 (-) | 1692 | WP_001216185.1 | ABC transporter permease | - |
| EL096_RS06290 (NCTC12977_01227) | - | 1192419..1193429 (-) | 1011 | WP_050279185.1 | ABC transporter ATP-binding protein | - |
| EL096_RS06295 (NCTC12977_01228) | - | 1193533..1194600 (-) | 1068 | WP_023930326.1 | extracellular solute-binding protein | - |
| EL096_RS06300 (NCTC12977_01229) | - | 1194625..1195284 (-) | 660 | WP_000793812.1 | DUF1868 domain-containing protein | - |
| EL096_RS06305 (NCTC12977_01230) | galE | 1195464..1196474 (-) | 1011 | WP_050198011.1 | UDP-glucose 4-epimerase GalE | - |
| EL096_RS06310 (NCTC12977_01231) | galT | 1196487..1197962 (-) | 1476 | WP_000848795.1 | UDP-glucose--hexose-1-phosphate uridylyltransferase | - |
| EL096_RS06315 (NCTC12977_01232) | - | 1197980..1198615 (-) | 636 | WP_050084685.1 | phosphate signaling complex PhoU family protein | - |
| EL096_RS11835 (NCTC12977_01233) | - | 1198673..1199056 (-) | 384 | WP_001812628.1 | hypothetical protein | - |
| EL096_RS06325 (NCTC12977_01234) | - | 1199216..1199512 (-) | 297 | WP_000239027.1 | hypothetical protein | - |
Sequence
Protein
Download Length: 219 a.a. Molecular weight: 24820.92 Da Isoelectric Point: 7.2761
>NTDB_id=1120550 EL096_RS06210 WP_000565001.1 1178031..1178690(+) (cclA/cilC) [Streptococcus pneumoniae strain NCTC12977]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTPLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLLV
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTPLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLLV
Nucleotide
Download Length: 660 bp
>NTDB_id=1120550 EL096_RS06210 WP_000565001.1 1178031..1178690(+) (cclA/cilC) [Streptococcus pneumoniae strain NCTC12977]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTAGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCCCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
ATACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATTGATATCCGCATGGGTGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTAGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCCCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
ATACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATTGATATCCGCATGGGTGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| cclA/cilC | Streptococcus pneumoniae TIGR4 |
98.174 |
100 |
0.982 |
| cclA/cilC | Streptococcus pneumoniae Rx1 |
96.804 |
100 |
0.968 |
| cclA/cilC | Streptococcus pneumoniae D39 |
96.804 |
100 |
0.968 |
| cclA/cilC | Streptococcus pneumoniae R6 |
96.804 |
100 |
0.968 |
| cclA/cilC | Streptococcus mitis SK321 |
92.237 |
100 |
0.922 |
| cclA/cilC | Streptococcus mitis NCTC 12261 |
87.215 |
100 |
0.872 |