Detailed information NTG1120526

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: EL096_RS00135
• Genome accession: NZ_LR134294
• Coordinates: 23981..24718 (+)
• Length: 245 a.a.
• NCBI ID: WP_050221200.1
• Uniprot ID: A0AA44S714
• Organism: Streptococcus pneumoniae strain NCTC12977
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 18981..29718

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL096_RS00105 (NCTC12977_00020)	dnaJ	19226..20362 (+)	1137	WP_050073039.1	molecular chaperone DnaJ	-
EL096_RS00110 (NCTC12977_00021)	-	20742..21029 (-)	288	WP_000777760.1	hypothetical protein	-
EL096_RS00115 (NCTC12977_00022)	-	21039..21449 (-)	411	WP_001278301.1	HIT family protein	-
EL096_RS00120 (NCTC12977_00023)	pptA	21517..22248 (+)	732	WP_050221198.1	ABC transporter ATP-binding protein	Regulator
EL096_RS00125 (NCTC12977_00024)	-	22245..23294 (+)	1050	WP_050221199.1	ABC transporter permease	-
EL096_RS00130 (NCTC12977_00025)	-	23356..23685 (-)	330	WP_000132585.1	hypothetical protein	-
EL096_RS00135 (NCTC12977_00026)	comE/blpR	23981..24718 (+)	738	WP_050221200.1	response regulator transcription factor	Regulator
EL096_RS00140 (NCTC12977_00027)	-	24732..26081 (+)	1350	WP_050221201.1	sensor histidine kinase	-
EL096_RS12160	-	26315..26506 (+)	192	WP_376738204.1	hypothetical protein	-
EL096_RS00150 (NCTC12977_00029)	-	26707..26871 (+)	165	WP_049511538.1	hypothetical protein	-
EL096_RS00155 (NCTC12977_00030)	-	26868..27272 (+)	405	WP_050221203.1	hypothetical protein	-
EL096_RS12165	-	27543..27819 (+)	277	Protein_29	immunity protein	-
EL096_RS00170 (NCTC12977_00032)	-	27902..28285 (+)	384	WP_050221205.1	hypothetical protein	-
EL096_RS00175 (NCTC12977_00033)	-	28350..29039 (+)	690	WP_050221206.1	CPBP family intramembrane glutamic endopeptidase	-
EL096_RS00180 (NCTC12977_00034)	blpZ	29081..29329 (+)	249	WP_050221207.1	immunity protein BlpZ	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28828.99 Da
• Isoelectric Point: 6.1688

>NTDB_id=1120526 EL096_RS00135 WP_050221200.1 23981..24718(+) (comE/blpR) [Streptococcus pneumoniae strain NCTC12977]
MRIFVLEDDFSQQTRIETTIEKLLKEHQIVPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVRLDKKEKLLYFPNGGSCMIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=1120526 EL096_RS00135 WP_050221200.1 23981..24718(+) (comE/blpR) [Streptococcus pneumoniae strain NCTC12977]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGAAAGAACA
TCAGATCGTTCCCAGCTCTTTTGAAGTTTTTGGTAAGCCAGACCAGCTGCTGGCAGAGGTGCATGAGAAGGGAGCTCATC
AGCTATTCTTTTTGGACATTGAGATTCGAAACGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATCCGGGATCGGGAT
CCTTATGCCTTGATAGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCTGCTCTAGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTTCTCTATGCCAATAGTCAAGATA
GTAAAAGTTTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAGTATCCTTTTAAAGAGGTTTATTAT
CTTGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCCAATGTAGTTCGTTTGGATA
AGAAAGAAAAACTTCTTTACTTTCCCAATGGTGGAAGCTGTATGATAGCGCGTTATAAGGTCAGGGAAGTGTCTGAAGCT
ATCAATAACTTACATTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	55.144	99.184	0.547
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	39.669	98.776	0.392
comE	Streptococcus infantis strain Atu-4	36.179	100	0.363