Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   EL087_RS04855 Genome accession   NZ_LR134288
Coordinates   985745..987091 (-) Length   448 a.a.
NCBI ID   WP_106083386.1    Uniprot ID   -
Organism   Streptococcus milleri strain NCTC11169     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 980745..992091
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL087_RS04835 (NCTC11169_00963) rpsT 981289..981540 (+) 252 WP_020999623.1 30S ribosomal protein S20 -
  EL087_RS04840 (NCTC11169_00964) - 981604..982113 (+) 510 WP_003042186.1 DNA topology modulation protein -
  EL087_RS04845 (NCTC11169_00965) - 982161..983774 (-) 1614 WP_126407165.1 M20/M25/M40 family metallo-hydrolase -
  EL087_RS04850 (NCTC11169_00966) - 983951..985399 (+) 1449 WP_126407167.1 alpha-amylase -
  EL087_RS04855 (NCTC11169_00967) ciaH 985745..987091 (-) 1347 WP_106083386.1 sensor histidine kinase Regulator
  EL087_RS04860 (NCTC11169_00968) ciaR 987081..987755 (-) 675 WP_003024352.1 response regulator transcription factor Regulator
  EL087_RS04865 (NCTC11169_00969) - 988028..988480 (-) 453 WP_126407169.1 hypothetical protein -
  EL087_RS09350 (NCTC11169_00970) - 988956..989357 (-) 402 WP_232008231.1 hypothetical protein -
  EL087_RS04880 (NCTC11169_00973) rplS 989800..990147 (-) 348 WP_003024326.1 50S ribosomal protein L19 -
  EL087_RS04885 (NCTC11169_00974) - 990297..991256 (-) 960 WP_126407171.1 ROK family glucokinase -
  EL087_RS09355 (NCTC11169_00975) - 991477..991980 (+) 504 WP_232008232.1 LysR family transcriptional regulator -

Sequence

Protein


Download         Length: 448 a.a.        Molecular weight: 50932.66 Da        Isoelectric Point: 10.1292

>NTDB_id=1120265 EL087_RS04855 WP_106083386.1 985745..987091(-) (ciaH) [Streptococcus milleri strain NCTC11169]
MLNKLKKTWYADDFSYFIRNFGIFTLIFSAMTLIIIQVMRSSLYTTVDNNLKSLSQDSASVINLALARRVGLEQKSDNGE
PKADTGDKELTDKPNVSANTEVILFDKDYKPIITSNNFLGLNKLSFNSKQLDRIRQVQVKSNYGREETYRTILFKVKLPN
LETNVKYAAVFINISQLEQTSQNHEQLIVVVMISFWGISLIASVYLARVSVKPLLESIQKQKSFVENASHELRTPLAVLQ
NRLETLFRKPEATIMESSESIASSLDEVRNMKMLTTNLLNLARRDDGIKPEIGDVEPNFFNTTFTNYEMVAAENGKTFRF
DNRIHRMIKTDKTLLKQLMTILFDNALKYTDEDGVIELTISANDRTLFLKVADNGPGISTADKKKIFDRFYRVDKARTRQ
TGGFGLGLSLAKQITEALKGTITVKDNKPKGTIFEVKIAIRTDNRKKK

Nucleotide


Download         Length: 1347 bp        

>NTDB_id=1120265 EL087_RS04855 WP_106083386.1 985745..987091(-) (ciaH) [Streptococcus milleri strain NCTC11169]
ATGCTGAATAAACTAAAAAAAACATGGTATGCGGATGATTTTTCTTATTTCATTCGCAATTTTGGTATTTTTACTCTCAT
TTTCTCAGCCATGACTTTGATTATCATTCAGGTGATGCGCTCAAGCCTTTATACAACGGTCGATAATAACTTGAAAAGTC
TCAGTCAGGATTCCGCTTCTGTCATCAATTTGGCGCTCGCTCGTAGAGTGGGGCTGGAACAGAAGTCAGACAACGGAGAG
CCTAAAGCCGATACGGGTGACAAAGAGCTTACTGATAAACCAAATGTCAGTGCCAATACGGAAGTTATCTTATTTGATAA
GGATTACAAGCCGATTATTACTAGCAATAATTTTCTGGGACTTAACAAACTTTCCTTTAATAGCAAGCAATTGGATCGCA
TTCGGCAAGTTCAAGTAAAAAGCAATTATGGGCGTGAAGAAACCTATCGGACGATTTTATTTAAGGTGAAATTGCCTAAT
TTGGAAACGAACGTTAAATACGCAGCTGTCTTTATCAATATCAGCCAATTGGAACAAACCAGTCAAAATCATGAGCAGCT
GATTGTAGTTGTGATGATTAGTTTCTGGGGAATTTCTTTGATTGCCAGTGTCTATCTGGCTCGGGTTAGTGTTAAACCTT
TGTTGGAGAGTATTCAAAAGCAAAAGAGCTTTGTTGAAAATGCTAGCCACGAGTTGCGCACACCTCTAGCAGTTTTGCAA
AATCGCTTGGAAACCTTGTTTAGAAAACCAGAAGCCACCATTATGGAATCAAGCGAAAGCATTGCTTCTAGTTTGGACGA
AGTCCGGAACATGAAAATGTTGACGACAAATCTACTCAATCTAGCACGACGCGATGACGGGATTAAACCAGAAATTGGCG
ATGTCGAGCCAAATTTCTTTAATACGACCTTTACCAACTATGAGATGGTTGCCGCAGAAAATGGGAAAACTTTCCGATTT
GACAATAGGATTCACCGCATGATTAAAACAGACAAGACCTTGCTGAAGCAATTGATGACAATTCTGTTTGATAATGCCTT
GAAATATACAGATGAAGACGGTGTAATTGAGTTGACGATTTCAGCGAATGACCGGACCCTTTTTTTGAAAGTTGCAGATA
ATGGTCCGGGGATTAGTACGGCAGATAAGAAAAAGATTTTTGATCGTTTTTATCGTGTTGATAAAGCACGGACTCGGCAG
ACAGGCGGTTTTGGTCTAGGCTTGTCGCTTGCAAAGCAAATCACAGAAGCCCTTAAAGGGACTATTACGGTGAAAGATAA
TAAGCCGAAAGGAACCATTTTTGAGGTGAAGATTGCCATTAGAACGGACAATAGAAAGAAAAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(331-438)

His Kinase A (phospho-acceptor) domain (HisKA)

(222-287)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

71.205

100

0.712
  ciaH Streptococcus pneumoniae D39

71.205

100

0.712
  ciaH Streptococcus pneumoniae R6

71.205

100

0.712
  ciaH Streptococcus pneumoniae TIGR4

71.205

100

0.712
  ciaH Streptococcus mutans UA159

56.591

98.214

0.556

Multiple sequence alignment