Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   EL070_RS08645 Genome accession   NZ_LR134284
Coordinates   1620905..1621591 (-) Length   228 a.a.
NCBI ID   WP_126405173.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC8232     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1615905..1626591
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL070_RS08625 (NCTC8232_01735) - 1616203..1617378 (-) 1176 WP_111705457.1 replication initiation and membrane attachment family protein -
  EL070_RS08630 (NCTC8232_01736) nrdR 1617362..1617856 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  EL070_RS08635 (NCTC8232_01738) - 1618030..1619163 (-) 1134 WP_000564846.1 ISAs1-like element IS1548 family transposase -
  EL070_RS08640 (NCTC8232_01739) covS 1619397..1620899 (-) 1503 WP_002985946.1 two-component system sensor histidine kinase CovS -
  EL070_RS08645 (NCTC8232_01740) covR 1620905..1621591 (-) 687 WP_126405173.1 two-component system response regulator CovR Regulator
  EL070_RS08650 (NCTC8232_01741) - 1621858..1622391 (-) 534 WP_011054200.1 YceD family protein -
  EL070_RS08655 (NCTC8232_01742) htpX 1622625..1623521 (-) 897 WP_002985953.1 zinc metalloprotease HtpX -
  EL070_RS08660 (NCTC8232_01743) - 1623568..1624125 (-) 558 WP_002985956.1 LemA family protein -
  EL070_RS08665 (NCTC8232_01744) rsmG 1624275..1624988 (+) 714 WP_002985957.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  EL070_RS08670 (NCTC8232_01745) ktrB 1625073..1626449 (+) 1377 WP_023605004.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26586.64 Da        Isoelectric Point: 4.6586

>NTDB_id=1120123 EL070_RS08645 WP_126405173.1 1620905..1621591(-) (covR) [Streptococcus pyogenes strain NCTC8232]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEVDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=1120123 EL070_RS08645 WP_126405173.1 1620905..1621591(-) (covR) [Streptococcus pyogenes strain NCTC8232]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGCGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGGTGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGTATTT
ATCGAGATCTAGTTTTAAACCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

81.659

100

0.82
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment