Detailed information NTG1120010

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: EL079_RS02580
• Genome accession: NZ_LR134283
• Coordinates: 515223..517451 (+)
• Length: 742 a.a.
• NCBI ID: WP_003031687.1
• Uniprot ID: A0A3S4QLI5
• Organism: Streptococcus anginosus strain NCTC10713
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 510223..522451

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL079_RS02555	rpmG	511077..511226 (+)	150	WP_003024746.1	50S ribosomal protein L33	-
EL079_RS02560 (NCTC10713_00552)	secG	511266..511499 (+)	234	WP_003024744.1	preprotein translocase subunit SecG	-
EL079_RS02565 (NCTC10713_00553)	rnr	511591..513924 (+)	2334	WP_018543505.1	ribonuclease R	-
EL079_RS02570 (NCTC10713_00554)	smpB	513887..514354 (+)	468	WP_003031704.1	SsrA-binding protein SmpB	-
EL079_RS02575 (NCTC10713_00555)	comEA/celA/cilE	514535..515239 (+)	705	WP_003031685.1	helix-hairpin-helix domain-containing protein	Machinery gene
EL079_RS02580 (NCTC10713_00556)	comEC/celB	515223..517451 (+)	2229	WP_003031687.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
EL079_RS02585 (NCTC10713_00557)	-	517534..518100 (+)	567	WP_223349562.1	DUF805 domain-containing protein	-
EL079_RS02590 (NCTC10713_00559)	-	518731..519717 (+)	987	WP_003024723.1	Gfo/Idh/MocA family protein	-
EL079_RS02595 (NCTC10713_00560)	-	519739..520392 (+)	654	WP_018543504.1	uracil-DNA glycosylase	-
EL079_RS02600 (NCTC10713_00561)	-	520429..520899 (+)	471	WP_003031692.1	8-oxo-dGTP diphosphatase	-
EL079_RS02605 (NCTC10713_00562)	-	520912..522189 (+)	1278	WP_018543503.1	dihydroorotase	-

Sequence

Protein

• Length: 742 a.a.
• Molecular weight: 85366.30 Da
• Isoelectric Point: 10.0727

>NTDB_id=1120010 EL079_RS02580 WP_003031687.1 515223..517451(+) (comEC/celB) [Streptococcus anginosus strain NCTC10713]
MSQWIKRFPIKPIYIAFLLVWLYFAIYQSSWLGWLGFIFLVICLFRFYSPKECFMTFMILSCFAGFFFVRREIAEQKTKV
EPSPIRQVAVLPDTIKVNGDSLSFRGKANRQTYQVYYKLKSKEEQLAFQNLSSLVTLTVEGEFEIPEKKRNFAGFDYQSY
LKTQGIYRILKVDTILSSQDRISLHPFEWLSSWRRKALVFIKNHFPNPMSNYMTGLLFGALDTSFDEMSNLYSSLGIIHL
FALSGMQVGFFMEGFRKLLLRLGFTQEMVRKCQYPFSFFYAGMTGFSVSVVRSLVQKLLSQHGITKLDNFALTMMILSLI
MPSFLLSAGGVLSCAYAFVISVIDFESLTSWRKVVVESSVISLGVLPILIFYFGEFQPWSILLTFVFSLIFDTMMLPGLM
FIFLFSPLIKLTQVNLLFEGLENSIRWIASVFGKPIVFGQPSPLLLIVMLLVLAILYDIRQNKKWVIFLSLFLSLLFFIN
KFPLQNEITMVDVGQGDSIFLRDWKGNNVLIDVGGREEIRIKEAWQKRATSSNAEKTLIPYLKSRGIDTIDTLVLTNPNP
DYAGDVLKVVKKFAVKKIFISRSSLNDADFLNKLKETRTFVHVVKQGDKLPIFDHHLQVLSGTNKNDQSLVLYGQFFRTR
FLFMSNLTEEDEIKLMQLYPKLKTDVLKVGQHGAKNSSHSKFLQQIEPAVALISVGKNNQSKSPNQETIERLNRFNAKIY
RTDKQGAIKLSGWTKWQLETVQ

Nucleotide

• Length: 2229 bp

>NTDB_id=1120010 EL079_RS02580 WP_003031687.1 515223..517451(+) (comEC/celB) [Streptococcus anginosus strain NCTC10713]
ATGTCACAGTGGATTAAAAGATTTCCGATTAAGCCGATTTACATTGCTTTTTTGCTCGTCTGGTTGTATTTTGCAATCTA
TCAAAGTAGCTGGTTAGGCTGGTTGGGTTTTATCTTTCTGGTGATTTGTCTTTTTCGCTTTTATTCACCGAAAGAATGTT
TCATGACCTTCATGATCCTCTCTTGTTTTGCTGGTTTTTTCTTTGTTCGTAGGGAAATAGCAGAGCAGAAGACGAAAGTA
GAACCTTCTCCCATAAGACAAGTGGCAGTTCTACCTGACACGATTAAGGTAAATGGTGATTCGCTTTCTTTTCGTGGTAA
AGCTAATAGGCAGACTTATCAAGTTTACTACAAATTGAAATCAAAGGAAGAACAGTTGGCTTTTCAAAATCTCTCTAGTC
TGGTTACATTGACCGTTGAAGGGGAATTTGAAATCCCTGAGAAGAAGCGTAATTTTGCTGGTTTTGATTACCAATCCTAT
TTAAAAACGCAAGGGATTTATCGAATTTTAAAAGTGGATACCATTTTATCGAGCCAAGATAGAATCAGCTTGCACCCTTT
TGAGTGGCTTTCTAGCTGGCGAAGAAAAGCACTGGTATTTATCAAGAACCATTTTCCAAATCCGATGAGTAATTACATGA
CAGGACTCTTATTTGGTGCCTTGGATACATCCTTTGACGAAATGAGCAATCTTTATTCTAGCTTGGGAATTATTCATTTA
TTTGCGCTGTCTGGCATGCAAGTTGGCTTTTTTATGGAGGGATTTCGCAAGTTACTGTTAAGGCTGGGGTTTACACAAGA
AATGGTTCGTAAATGCCAATATCCATTTTCTTTCTTTTATGCGGGAATGACTGGATTTTCAGTATCCGTTGTACGGAGCT
TAGTTCAGAAATTATTATCGCAACATGGTATCACTAAGTTAGATAATTTTGCTTTAACGATGATGATATTGTCCTTGATT
ATGCCGTCCTTTCTTTTGTCGGCAGGAGGAGTTCTCTCCTGTGCTTATGCTTTTGTCATTAGTGTGATAGATTTTGAAAG
TCTGACTTCTTGGCGAAAAGTTGTTGTAGAGAGTAGCGTTATTTCACTTGGTGTTTTACCAATTCTAATCTTTTACTTTG
GTGAATTTCAACCTTGGTCTATTTTGTTGACATTTGTTTTTTCACTAATTTTCGATACAATGATGCTGCCAGGCTTGATG
TTTATTTTTCTTTTTTCGCCTTTGATAAAGCTGACTCAAGTCAATCTTTTATTTGAAGGTTTAGAAAATAGTATTCGTTG
GATAGCAAGTGTCTTTGGTAAACCAATCGTTTTTGGGCAGCCCAGTCCGCTTTTGCTGATTGTCATGTTACTTGTACTAG
CTATTTTGTACGATATTCGGCAAAATAAAAAGTGGGTAATATTTCTTAGTCTGTTTCTTTCATTACTATTTTTCATAAAT
AAATTTCCTTTGCAAAACGAGATCACAATGGTTGATGTCGGACAGGGAGATAGTATTTTTCTGAGAGATTGGAAAGGAAA
TAATGTATTGATTGATGTTGGTGGACGTGAGGAAATTAGAATAAAAGAAGCTTGGCAAAAACGAGCAACTAGCTCAAATG
CAGAGAAAACTTTGATTCCTTACCTAAAAAGTCGTGGCATAGATACGATTGATACTTTAGTCTTAACAAATCCTAATCCA
GATTATGCAGGAGATGTATTAAAAGTGGTTAAAAAGTTTGCGGTAAAGAAAATTTTTATTTCCAGAAGTAGTTTGAATGA
TGCAGACTTTTTAAATAAATTAAAGGAGACAAGGACGTTTGTTCATGTCGTAAAACAAGGAGACAAACTTCCTATTTTTG
ATCATCATTTGCAAGTTCTTTCTGGTACGAATAAGAATGATCAATCGCTAGTTTTATATGGTCAATTTTTTCGTACAAGG
TTTTTATTTATGAGCAATTTAACAGAAGAGGATGAAATAAAGCTAATGCAACTTTATCCAAAGCTAAAAACAGATGTCTT
GAAGGTTGGGCAACATGGAGCCAAAAATTCATCACATTCAAAATTTTTACAGCAAATAGAACCGGCAGTTGCACTCATTT
CTGTTGGGAAAAATAACCAATCCAAATCTCCGAATCAAGAGACGATAGAGCGATTGAATCGCTTCAATGCGAAGATTTAT
CGAACGGATAAACAAGGCGCTATCAAACTTTCAGGATGGACAAAATGGCAATTAGAAACAGTTCAATAG

Domains

Predicted by InterproScan.

• Metallo-beta-lactamase superfamily (Lactamase_B) (493-578)

• Competence protein (Competence) (216-461)

• Domain of unknown function (DUF4131) (DUF4131) (29-175)

3D structure

• AlphaFold DB: A0A3S4QLI5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis SK321	55.154	100	0.555
comEC/celB	Streptococcus mitis NCTC 12261	54.424	100	0.547
comEC/celB	Streptococcus pneumoniae TIGR4	53.949	100	0.543
comEC/celB	Streptococcus pneumoniae Rx1	53.146	100	0.535
comEC/celB	Streptococcus pneumoniae D39	53.146	100	0.535
comEC/celB	Streptococcus pneumoniae R6	53.146	100	0.535
comEC	Lactococcus lactis subsp. cremoris KW2	46.64	100	0.468