Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   EL086_RS06165 Genome accession   NZ_LR134274
Coordinates   1263438..1264853 (-) Length   471 a.a.
NCBI ID   WP_004182392.1    Uniprot ID   A0AB33ZDN7
Organism   Streptococcus salivarius strain NCTC8618     
Function   Required for optimal comC expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1258438..1269853
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EL086_RS06135 (NCTC8618_03652) - 1259076..1259474 (-) 399 WP_021144038.1 cytidine deaminase -
  EL086_RS06140 (NCTC8618_03653) deoC 1259479..1260123 (-) 645 WP_014634599.1 deoxyribose-phosphate aldolase -
  EL086_RS06145 (NCTC8618_03654) - 1260157..1261434 (-) 1278 WP_014634600.1 pyrimidine-nucleoside phosphorylase -
  EL086_RS06150 (NCTC8618_03655) - 1261431..1262021 (-) 591 WP_014633038.1 class I SAM-dependent methyltransferase -
  EL086_RS06155 (NCTC8618_03656) coaA 1262134..1263054 (+) 921 WP_038676170.1 type I pantothenate kinase -
  EL086_RS06160 (NCTC8618_03657) rpsT 1263124..1263360 (+) 237 WP_004182129.1 30S ribosomal protein S20 -
  EL086_RS06165 (NCTC8618_03658) ciaH 1263438..1264853 (-) 1416 WP_004182392.1 sensor histidine kinase Regulator
  EL086_RS06170 (NCTC8618_03659) ciaR 1264843..1265517 (-) 675 WP_002891134.1 response regulator transcription factor Regulator
  EL086_RS06175 (NCTC8618_03660) - 1265715..1267385 (-) 1671 WP_004182072.1 formate--tetrahydrofolate ligase -
  EL086_RS06180 (NCTC8618_03661) - 1267580..1268263 (+) 684 WP_022496696.1 phosphopantothenate--cysteine ligase -
  EL086_RS06185 (NCTC8618_03662) coaC 1268256..1268801 (+) 546 WP_022496697.1 phosphopantothenoylcysteine decarboxylase -
  EL086_RS06190 (NCTC8618_03663) - 1268830..1269402 (+) 573 WP_022496698.1 ECF transporter S component -

Sequence

Protein


Download         Length: 471 a.a.        Molecular weight: 53504.28 Da        Isoelectric Point: 8.7661

>NTDB_id=1119825 EL086_RS06165 WP_004182392.1 1263438..1264853(-) (ciaH) [Streptococcus salivarius strain NCTC8618]
MLTKFFNYLFRRIKSDGFKSFIHFFATFSGIFLIMTVMILQILSYGVYSNVDSSLKMAATKTNSYLEMEMLKRELFLTSE
VDQNNTTTIYQAYDTKESTAETPDSSGSKKEPKKKSKIEDTPHDLSVAANTSVLVLDKNGKVLNVVDKFSSLSNLPIDKN
NIDVISKGSAQNYFDQTEKYRLITEKVDNSLYPDAKYLVIAINTTQLEEATERYVKLIVIMMSFFWLLSVAASMYLAKWS
RRPIQESLEKQKAFVENASHELRTPLAVIQNRLEVLFRKPESTILDNSENIASSLDEVRNMRLLTTNLLNLARRDDGIKP
EIETLEPAFFDTVFTNYAMIAEENEKGFTAQNQVGRPIQTDKTLLKQLMTILFDNAIKYTEDDGHVTFTVRTNDRHLYIS
VADNGPGISDSDKKKIFDRFYRVDKARTRQKGGFGLGLSLAQQIVLALKGTIVVKDNQPKGTIFEVKITGV

Nucleotide


Download         Length: 1416 bp        

>NTDB_id=1119825 EL086_RS06165 WP_004182392.1 1263438..1264853(-) (ciaH) [Streptococcus salivarius strain NCTC8618]
ATGCTGACTAAATTTTTCAATTATCTCTTTAGGAGAATCAAGTCAGACGGATTTAAGTCGTTCATTCATTTCTTTGCCAC
TTTTTCTGGTATTTTCCTTATCATGACTGTCATGATTTTGCAGATTCTGAGTTACGGCGTTTATTCCAATGTGGACTCTA
GTCTGAAAATGGCAGCCACTAAAACCAATTCTTATTTAGAAATGGAAATGCTAAAACGGGAACTTTTTCTGACTTCTGAG
GTAGATCAAAATAATACGACAACCATTTACCAAGCCTATGATACTAAAGAGTCGACAGCTGAAACACCTGACTCGAGTGG
CTCTAAGAAAGAGCCTAAGAAGAAATCAAAAATTGAAGATACCCCTCACGATTTATCTGTTGCGGCAAATACTAGTGTCT
TGGTACTTGATAAGAATGGAAAAGTCCTTAATGTTGTTGATAAATTTTCAAGCTTATCCAATTTACCAATAGACAAAAAT
AACATTGATGTTATCAGCAAGGGAAGTGCTCAGAATTATTTCGATCAAACGGAAAAGTACCGTCTGATTACTGAAAAAGT
AGATAATAGCCTCTATCCTGATGCTAAGTACCTTGTTATTGCGATTAATACAACTCAATTGGAAGAAGCCACTGAACGTT
ATGTTAAGCTAATTGTCATCATGATGAGTTTCTTCTGGCTTTTATCTGTTGCGGCTAGTATGTATTTGGCTAAGTGGTCA
AGACGTCCTATCCAGGAAAGCTTGGAGAAGCAGAAGGCTTTTGTTGAGAATGCTAGCCATGAGTTACGGACACCGCTTGC
TGTGATTCAAAACAGATTAGAAGTTCTTTTCCGCAAGCCTGAGAGCACCATTCTAGATAATTCAGAGAATATTGCTTCAA
GTCTTGATGAAGTACGCAACATGCGTCTTTTGACGACTAATCTTTTGAACTTGGCTCGTCGTGACGATGGTATTAAACCA
GAAATCGAAACCTTAGAACCTGCTTTCTTTGATACAGTCTTTACCAACTATGCCATGATTGCAGAAGAAAATGAGAAAGG
TTTCACGGCTCAAAACCAAGTTGGTCGTCCAATCCAGACTGATAAAACGTTATTGAAACAGTTAATGACCATCTTATTTG
ATAATGCGATTAAATATACGGAAGATGACGGACATGTTACCTTTACTGTCCGCACTAATGACCGGCATCTTTATATTTCT
GTAGCTGATAATGGTCCTGGAATATCAGATAGTGATAAGAAAAAAATCTTTGATCGATTTTATCGCGTAGATAAGGCTAG
AACCAGACAAAAAGGTGGGTTTGGACTTGGCTTATCCCTAGCGCAACAAATTGTTTTAGCCCTTAAAGGAACAATTGTTG
TTAAAGATAATCAACCAAAGGGAACGATTTTTGAAGTTAAGATCACCGGAGTTTAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(361-468)

His Kinase A (phospho-acceptor) domain (HisKA)

(252-317)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus mutans UA159

56.739

97.665

0.554
  ciaH Streptococcus pneumoniae Rx1

50.216

98.514

0.495
  ciaH Streptococcus pneumoniae D39

50.216

98.514

0.495
  ciaH Streptococcus pneumoniae R6

50.216

98.514

0.495
  ciaH Streptococcus pneumoniae TIGR4

50.216

98.514

0.495

Multiple sequence alignment