Detailed information NTG1119754

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: EL077_RS04590
• Genome accession: NZ_LR134273
• Coordinates: 976640..977314 (+)
• Length: 224 a.a.
• NCBI ID: WP_021320708.1
• Uniprot ID: A0AAW3GMV5
• Organism: Streptococcus equi subsp. equi strain NCTC12091
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 971640..982314

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EL077_RS04575 (NCTC12091_00928)	pstB	971967..972725 (+)	759	WP_012678019.1	phosphate ABC transporter ATP-binding protein PstB	-
EL077_RS04580 (NCTC12091_00929)	phoU	972796..973449 (+)	654	WP_012678018.1	phosphate signaling complex protein PhoU	-
EL077_RS04585 (NCTC12091_00930)	-	973684..976221 (+)	2538	WP_043052123.1	M1 family metallopeptidase	-
EL077_RS04590 (NCTC12091_00931)	ciaR	976640..977314 (+)	675	WP_021320708.1	response regulator transcription factor	Regulator
EL077_RS04595 (NCTC12091_00932)	ciaH	977307..978617 (+)	1311	WP_012515549.1	sensor histidine kinase	Regulator
EL077_RS04600 (NCTC12091_00933)	-	979002..979436 (+)	435	WP_012678015.1	hypothetical protein	-
EL077_RS09925 (NCTC12091_00934)	-	979518..979694 (+)	177	WP_014622814.1	hypothetical protein	-
EL077_RS04605 (NCTC12091_00935)	-	979710..980117 (+)	408	WP_014622815.1	hypothetical protein	-
EL077_RS04610 (NCTC12091_00936)	-	980127..980417 (+)	291	WP_126436648.1	hypothetical protein	-
EL077_RS04615 (NCTC12091_00937)	-	980341..980724 (+)	384	WP_126436650.1	hypothetical protein	-
EL077_RS04620 (NCTC12091_00938)	-	980726..980977 (+)	252	WP_043029681.1	hypothetical protein	-
EL077_RS04625 (NCTC12091_00939)	-	981152..981532 (+)	381	WP_043029682.1	hypothetical protein	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25569.58 Da
• Isoelectric Point: 4.5644

>NTDB_id=1119754 EL077_RS04590 WP_021320708.1 976640..977314(+) (ciaR) [Streptococcus equi subsp. equi strain NCTC12091]
MIKLLLVEDDLSLSNSIFDFLDDFADVTQVFDGDEGLYEAESGIYDLILLDLMLPEKDGFQVLKALREKDIKIPVLIMTA
KESIDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRVGKFNDKSLKFGNLTVDTTRKEVQVNGQVIELLGKELDLLIY
ILQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTDFVNHLQTLRSVGYILKANE

Nucleotide

• Length: 675 bp

>NTDB_id=1119754 EL077_RS04590 WP_021320708.1 976640..977314(+) (ciaR) [Streptococcus equi subsp. equi strain NCTC12091]
ATGATAAAACTATTATTAGTAGAAGACGATTTAAGCTTATCAAATTCCATCTTTGATTTTTTAGATGACTTTGCTGATGT
GACCCAGGTTTTTGATGGCGACGAAGGACTCTATGAGGCAGAAAGCGGCATTTATGATTTGATTCTGTTAGATTTGATGC
TGCCTGAAAAGGATGGCTTTCAAGTGCTAAAGGCCTTACGTGAAAAAGACATCAAAATTCCCGTCTTGATCATGACTGCC
AAAGAAAGCATTGATGACAAGGGACATGGCTTTGAGCTTGGTGCTGATGACTATTTAACCAAGCCCTTTTACCTAGAGGA
ATTAAAAATGCGGATTCAGGCCTTGCTTAAGCGCGTAGGAAAGTTTAATGATAAGAGCCTTAAATTTGGCAACCTGACTG
TAGATACTACCCGTAAAGAGGTACAGGTCAATGGGCAGGTCATAGAGCTATTAGGCAAGGAGCTTGATTTACTAATCTAT
ATCCTTCAAAATCAAAATGTTATTTTGCCAAAGTCACAAATTTTTGATCGTATCTGGGGCTTTGATAGTGATACCACTAT
CTCTGTTGTAGAGGTCTATGTCTCTAAAATCCGTAAGAAGCTTAAGGGGACAGACTTTGTTAATCATCTTCAAACCTTGA
GAAGTGTAGGATATATCTTAAAAGCTAATGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (5-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	84.615	98.661	0.835
ciaR	Streptococcus pneumoniae Rx1	80.543	98.661	0.795
ciaR	Streptococcus pneumoniae D39	80.543	98.661	0.795
ciaR	Streptococcus pneumoniae R6	80.543	98.661	0.795
ciaR	Streptococcus pneumoniae TIGR4	80.543	98.661	0.795
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.865	100	0.397