Detailed information NTG1116709

Bioinformatically predicted

Overview

• Name: comYB
• Type: Machinery gene
• Locus tag: EW022_RS00665
• Genome accession: NZ_LR130240
• Coordinates: 102217..103251 (+)
• Length: 344 a.a.
• NCBI ID: WP_227868694.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain PS006 isolate PS006
• Function: dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 97217..108251

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EW022_RS00655	-	100885..101250 (+)	366	WP_002986560.1	DUF1033 family protein	-
EW022_RS00660	comYA	101343..102281 (+)	939	WP_011284420.1	competence type IV pilus ATPase ComGA	Machinery gene
EW022_RS00665	comYB	102217..103251 (+)	1035	WP_227868694.1	competence type IV pilus assembly protein ComGB	Machinery gene
EW022_RS00670	comYC	103253..103579 (+)	327	WP_002986552.1	competence type IV pilus major pilin ComGC	Machinery gene
EW022_RS00675	comGD	103554..103982 (+)	429	WP_002986548.1	competence type IV pilus minor pilin ComGD	-
EW022_RS00680	comGE	103939..104223 (+)	285	WP_011284422.1	competence type IV pilus minor pilin ComGE	-
EW022_RS00685	comYF	104216..104650 (+)	435	WP_002992738.1	competence type IV pilus minor pilin ComGF	Machinery gene
EW022_RS00690	comGG	104634..104960 (+)	327	WP_010921801.1	competence type IV pilus minor pilin ComGG	-
EW022_RS00695	comYH	105058..106011 (+)	954	WP_010921802.1	class I SAM-dependent methyltransferase	Machinery gene
EW022_RS00700	-	106070..107266 (+)	1197	WP_011284424.1	acetate kinase	-
EW022_RS00705	-	107453..107761 (+)	309	WP_011284425.1	hypothetical protein	-

Sequence

Protein

• Length: 344 a.a.
• Molecular weight: 39734.19 Da
• Isoelectric Point: 9.6101

>NTDB_id=1116709 EW022_RS00665 WP_227868694.1 102217..103251(+) (comYB) [Streptococcus pyogenes strain PS006 isolate PS006]
MISFLRQDISIPSKLSLKKLSSKHQHKFIQLLANLLSTGFSFAEVIAFLKRSQLLQLDYVLKMEESLLKGQDLADMLSGL
GFSDAILTQISLADRHGNIETTLVAIQHYLNQMARIRRKTVEVITYPLILLLFLFVMMLGLRRYLVPQLETQNQITYFLN
HFPAFFIGFCSGLILLFGMVWLRWRSQSRLKLYSRLSRYPFLGKLLKQYLTSYYAREWGTLIGQGLDLMTILDIMAIEKS
SLMKELAEDIRMSLLEGQAFHIKVATYPFFKKELSLMIEYGEIKSKLGAELEIYAQESWEQFFSQLYQVTQLIQPAIFLV
VAVTIVMIYAAILLPIYQNMGGIF

Nucleotide

• Length: 1035 bp

>NTDB_id=1116709 EW022_RS00665 WP_227868694.1 102217..103251(+) (comYB) [Streptococcus pyogenes strain PS006 isolate PS006]
TTGATCAGCTTCTTGAGGCAGGACATCTCAATCCCAAGCAAGCTAAGCTTGAAAAAATTATCTAGTAAACATCAGCATAA
ATTCATTCAATTACTAGCTAATCTTTTATCTACAGGATTTAGCTTCGCAGAGGTTATTGCTTTTTTAAAAAGAAGCCAGT
TGCTTCAGCTAGATTATGTTCTTAAAATGGAAGAGTCTTTATTAAAAGGACAAGACTTAGCAGATATGTTGTCGGGTTTA
GGTTTTTCAGATGCTATTCTTACTCAAATTAGTTTAGCTGATAGACACGGTAATATTGAAACAACATTAGTAGCGATTCA
ACATTACTTGAACCAAATGGCAAGGATCAGACGAAAAACTGTTGAAGTTATCACCTATCCTCTTATTCTTTTACTTTTTC
TTTTTGTGATGATGCTAGGGTTGAGACGCTATTTAGTCCCTCAATTAGAAACTCAAAATCAGATAACTTACTTTCTTAAC
CATTTTCCTGCCTTCTTTATAGGTTTTTGCTCAGGTCTTATTTTGTTGTTCGGGATGGTATGGCTACGATGGCGATCTCA
AAGCCGCTTGAAACTCTATAGTCGGCTAAGCCGTTATCCTTTTTTAGGTAAACTGTTAAAACAATACTTAACTAGTTATT
ATGCTAGAGAATGGGGTACGTTAATAGGTCAAGGTCTTGATTTGATGACTATTTTAGACATTATGGCCATTGAGAAATCC
TCACTAATGAAAGAATTAGCTGAGGACATCAGAATGAGTCTGCTTGAAGGGCAAGCCTTTCACATTAAAGTAGCTACCTA
CCCTTTTTTTAAAAAAGAATTAAGTTTAATGATTGAATACGGTGAAATCAAATCGAAACTGGGGGCTGAGTTGGAAATCT
ATGCCCAGGAAAGCTGGGAACAATTTTTTAGTCAGCTTTATCAAGTGACACAACTTATTCAACCAGCTATTTTTTTAGTA
GTTGCTGTGACAATCGTCATGATTTATGCGGCAATCCTATTACCAATTTACCAAAATATGGGAGGTATTTTTTAA

Domains

Predicted by InterproScan.

• Type II secretion system (T2SS), protein F (T2SSF) (28-147)

• Type II secretion system (T2SS), protein F (T2SSF) (215-335)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comYB	Streptococcus mutans UA140	53.982	98.547	0.532
comYB	Streptococcus mutans UA159	53.982	98.547	0.532
comYB	Streptococcus gordonii str. Challis substr. CH1	50.588	98.837	0.5
comGB/cglB	Streptococcus mitis NCTC 12261	47.619	97.674	0.465
comGB/cglB	Streptococcus mitis SK321	47.748	96.802	0.462
comGB/cglB	Streptococcus pneumoniae Rx1	45.646	96.802	0.442
comGB/cglB	Streptococcus pneumoniae D39	45.646	96.802	0.442
comGB/cglB	Streptococcus pneumoniae R6	45.646	96.802	0.442
comGB/cglB	Streptococcus pneumoniae TIGR4	45.646	96.802	0.442
comGB	Lactococcus lactis subsp. cremoris KW2	42.769	94.477	0.404