Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   EW023_RS01655 Genome accession   NZ_LR130239
Coordinates   303208..303894 (+) Length   228 a.a.
NCBI ID   WP_023612128.1    Uniprot ID   A0A0K0P1B7
Organism   Streptococcus pyogenes strain PS003 isolate PS003     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 298208..308894
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EW023_RS01630 ktrB 298349..299725 (-) 1377 WP_032465568.1 potassium uptake transporter channel subunit KtrB -
  EW023_RS01635 rsmG 299810..300523 (-) 714 WP_023612126.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  EW023_RS01640 - 300673..301230 (+) 558 WP_002985956.1 LemA family protein -
  EW023_RS01645 htpX 301277..302173 (+) 897 WP_023612133.1 zinc metalloprotease HtpX -
  EW023_RS01650 - 302407..302940 (+) 534 WP_011054200.1 YceD family protein -
  EW023_RS01655 covR 303208..303894 (+) 687 WP_023612128.1 two-component system response regulator CovR Regulator
  EW023_RS01660 covS 303900..305402 (+) 1503 WP_002991036.1 two-component system sensor histidine kinase CovS -
  EW023_RS01665 nrdR 305617..306111 (+) 495 WP_002985941.1 transcriptional regulator NrdR -
  EW023_RS01670 - 306095..307270 (+) 1176 WP_023612130.1 replication initiation and membrane attachment family protein -
  EW023_RS01675 dnaI 307271..308173 (+) 903 WP_002991016.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26600.66 Da        Isoelectric Point: 4.6586

>NTDB_id=1116669 EW023_RS01655 WP_023612128.1 303208..303894(+) (covR) [Streptococcus pyogenes strain PS003 isolate PS003]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNINRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=1116669 EW023_RS01655 WP_023612128.1 303208..303894(+) (covR) [Streptococcus pyogenes strain PS003 isolate PS003]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATTAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)

Response regulator receiver domain (Response_reg)

(5-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0K0P1B7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

81.659

100

0.82
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment