Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   EW024_RS01590 Genome accession   NZ_LR130237
Coordinates   290884..291570 (+) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain SP444 isolate SP444     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 285884..296570
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EW024_RS01565 ktrB 286027..287403 (-) 1377 WP_032459855.1 potassium uptake transporter channel subunit KtrB -
  EW024_RS01570 rsmG 287487..288200 (-) 714 WP_011528267.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  EW024_RS01575 - 288350..288907 (+) 558 WP_002985956.1 LemA family protein -
  EW024_RS01580 htpX 288954..289850 (+) 897 WP_002985953.1 zinc metalloprotease HtpX -
  EW024_RS01585 - 290084..290617 (+) 534 WP_011054200.1 YceD family protein -
  EW024_RS01590 covR 290884..291570 (+) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  EW024_RS01595 covS 291576..293078 (+) 1503 WP_002985946.1 two-component system sensor histidine kinase CovS -
  EW024_RS01600 nrdR 293293..293787 (+) 495 WP_002985941.1 transcriptional regulator NrdR -
  EW024_RS01605 - 293771..294946 (+) 1176 WP_002991019.1 replication initiation and membrane attachment family protein -
  EW024_RS01610 dnaI 294947..295849 (+) 903 WP_011528269.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=1116555 EW024_RS01590 WP_002991052.1 290884..291570(+) (covR) [Streptococcus pyogenes strain SP444 isolate SP444]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=1116555 EW024_RS01590 WP_002991052.1 290884..291570(+) (covR) [Streptococcus pyogenes strain SP444 isolate SP444]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGCGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACATATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGACATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment