Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   EQB46_RS08725 Genome accession   NZ_LR129843
Coordinates   1613940..1614599 (+) Length   219 a.a.
NCBI ID   WP_000565024.1    Uniprot ID   A0A4J1XTA1
Organism   Streptococcus pneumoniae strain 180-2 isolate 180-2     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1608940..1619599
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQB46_RS08700 - 1609245..1609562 (-) 318 WP_001151646.1 PTS sugar transporter subunit IIB -
  EQB46_RS08705 - 1609577..1610473 (-) 897 WP_000825665.1 PEP phosphonomutase -
  EQB46_RS08710 - 1610476..1611738 (-) 1263 WP_000413345.1 PTS sugar transporter subunit IIC -
  EQB46_RS08715 - 1612018..1613196 (+) 1179 WP_000175878.1 ROK family transcriptional regulator -
  EQB46_RS08720 - 1613424..1613870 (-) 447 WP_000155412.1 GNAT family N-acetyltransferase -
  EQB46_RS08725 cclA/cilC 1613940..1614599 (+) 660 WP_000565024.1 prepilin peptidase Machinery gene
  EQB46_RS08730 - 1614651..1615802 (-) 1152 WP_000481758.1 XRE family transcriptional regulator -
  EQB46_RS08735 - 1615817..1616548 (-) 732 WP_000934017.1 hypothetical protein -
  EQB46_RS11530 - 1616774..1616878 (+) 105 Protein_1664 prepilin peptidase -
  EQB46_RS08745 trpA 1616850..1617626 (-) 777 WP_001127028.1 tryptophan synthase subunit alpha -
  EQB46_RS08750 trpB 1617619..1618842 (-) 1224 WP_000331297.1 tryptophan synthase subunit beta -
  EQB46_RS08755 - 1618820..1619419 (-) 600 WP_000169899.1 phosphoribosylanthranilate isomerase -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24951.16 Da        Isoelectric Point: 8.2409

>NTDB_id=1116359 EQB46_RS08725 WP_000565024.1 1613940..1614599(+) (cclA/cilC) [Streptococcus pneumoniae strain 180-2 isolate 180-2]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWKLLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILITSSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=1116359 EQB46_RS08725 WP_000565024.1 1613940..1614599(+) (cclA/cilC) [Streptococcus pneumoniae strain 180-2 isolate 180-2]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGAAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAACTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTATCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4J1XTA1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae TIGR4

96.804

100

0.968
  cclA/cilC Streptococcus pneumoniae Rx1

95.434

100

0.954
  cclA/cilC Streptococcus pneumoniae D39

95.434

100

0.954
  cclA/cilC Streptococcus pneumoniae R6

95.434

100

0.954
  cclA/cilC Streptococcus mitis SK321

91.324

100

0.913
  cclA/cilC Streptococcus mitis NCTC 12261

85.388

100

0.854

Multiple sequence alignment