Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   EQB41_RS02830 Genome accession   NZ_LR129840
Coordinates   508816..509553 (+) Length   245 a.a.
NCBI ID   WP_001219122.1    Uniprot ID   A0A0I5XJR5
Organism   Streptococcus pneumoniae strain 4496 isolate 4496     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 503816..514553
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQB41_RS11760 - 504702..504986 (-) 285 WP_001845431.1 hypothetical protein -
  EQB41_RS02800 - 505148..505435 (-) 288 WP_000777760.1 hypothetical protein -
  EQB41_RS02805 - 505445..505855 (-) 411 WP_001278301.1 HIT family protein -
  EQB41_RS02810 pptA 505923..506654 (+) 732 WP_127820732.1 ABC transporter ATP-binding protein Regulator
  EQB41_RS02815 - 506651..507700 (+) 1050 WP_000653767.1 ABC transporter permease -
  EQB41_RS02820 - 507868..508197 (-) 330 WP_127820733.1 helicase BlpT -
  EQB41_RS02825 - 508473..508811 (+) 339 WP_000682133.1 LytTR family DNA-binding domain-containing protein -
  EQB41_RS02830 comE/blpR 508816..509553 (+) 738 WP_001219122.1 response regulator transcription factor Regulator
  EQB41_RS02835 - 509566..510906 (+) 1341 WP_127820734.1 sensor histidine kinase -
  EQB41_RS02840 blpC 510977..511105 (-) 129 WP_000358815.1 quorum-sensing system pheromone BlpC -
  EQB41_RS02845 - 511162..512523 (-) 1362 WP_001069075.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28766.95 Da        Isoelectric Point: 6.4140

>NTDB_id=1116180 EQB41_RS02830 WP_001219122.1 508816..509553(+) (comE/blpR) [Streptococcus pneumoniae strain 4496 isolate 4496]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=1116180 EQB41_RS02830 WP_001219122.1 508816..509553(+) (comE/blpR) [Streptococcus pneumoniae strain 4496 isolate 4496]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGACATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGATCGGGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTTAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0I5XJR5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

53.909

99.184

0.535
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

38.43

98.776

0.38

Multiple sequence alignment