Detailed information NTG0111594

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: HAS68_RS02910
• Genome accession: NZ_CP002007
• Coordinates: 547465..549702 (+)
• Length: 745 a.a.
• NCBI ID: WP_009909666.1
• Uniprot ID: A0A7Y6RP41
• Organism: Streptococcus suis 05HAS68
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 542465..554702

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HAS68_RS02885 (HAS68_0501)	-	542536..543465 (-)	930	WP_009909659.1	ABC transporter substrate-binding protein	-
HAS68_RS02890 (HAS68_0502)	-	543462..544262 (-)	801	WP_013730319.1	ABC transporter ATP-binding protein	-
HAS68_RS02895 (HAS68_0503)	-	544414..545859 (-)	1446	WP_013730320.1	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L- lysine ligase	-
HAS68_RS02900 (HAS68_0504)	-	546005..546751 (+)	747	WP_013730321.1	1-acyl-sn-glycerol-3-phosphate acyltransferase	-
HAS68_RS02905 (HAS68_0505)	-	546819..547481 (+)	663	WP_009909665.1	helix-hairpin-helix domain-containing protein	-
HAS68_RS02910 (HAS68_0506)	comEC/celB	547465..549702 (+)	2238	WP_009909666.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
HAS68_RS11505	-	549719..549844 (+)	126	Protein_533	IS982 family transposase	-
HAS68_RS02920 (HAS68_0507)	-	550026..550682 (+)	657	WP_002935353.1	CBS domain-containing protein	-
HAS68_RS02925 (HAS68_0508)	-	550776..551603 (+)	828	WP_002935354.1	hypothetical protein	-
HAS68_RS02930 (HAS68_0509)	-	551609..552880 (+)	1272	WP_002935355.1	toxic anion resistance protein	-
HAS68_RS02935 (HAS68_0510)	-	552917..553783 (-)	867	WP_002935357.1	YitT family protein	-
HAS68_RS02940 (HAS68_0511)	tmk	553958..554596 (+)	639	WP_002935358.1	dTMP kinase	-

Sequence

Protein

• Length: 745 a.a.
• Molecular weight: 84156.93 Da
• Isoelectric Point: 7.3957

>NTDB_id=111594 HAS68_RS02910 WP_009909666.1 547465..549702(+) (comEC/celB) [Streptococcus suis 05HAS68]
MSRLSKLPCQPVHLAVLAVAAYFAVHSFSLLTMGLFSLLLAVFGVRQGKTVFLKTLPLLALCGLFFGYQKVQWERADQSA
TEQVTTVQVIPDTIDINGDSLSFRGRADGQTYQVFYKLTSQEEQTYFQKLTGLVQLEVEAEISLPAGQRNFKGFDYQAYL
KTQGIYRTVKITAIKKIVPVQSWNVFDWLSNWRRQALVYVKTNFPAPMSHYMTGLLFGDLDSDFDQMSDLYSSLGIIHLF
ALSGMQVGFVIDKFRWILLRLGLTKETVDKLQIPFSLVYASLTGFSVSVVRSLVQKILGNLGLRKLDNFAVTVFVCLLIL
PRFLLTAGGVLTFTYAFLLTVFDFEDLGQVKKAAVESLSISLGILPVLMTYFYAFQPLSILLTFAFSFVFDVLLLPGLSV
IFLLSPIVKITWVNGFFVFMEKIIVWVADLGLRPWILGKPSELVLLLLLVSLFLLYDFHRRKKWLLGLSLVLALLFFITK
HPLENEVTVVDIGQGDSIFLRDMRGRTVLIDVGGRVDFAAKEAWQERPRQANAERTLIPYLHSRGVDRIDSLVLTHTDTD
HVGDVLEVAKQVQIGRIYVSPGSLTVPDFVATLKEINVPVHVVEVGERLPIFDSYLEVLYPDGTGDGGNNDSIVLYGRLL
KTNFLFTGDLEQGELDLIESYPNLPVDVLKAGHHGSKGSSYPEFLDHIEAKIALVSAGENNRYKHPHQETLERFDSRNIQ
VYRTDQQGAIRFRGWREWRIETVRR

Nucleotide

• Length: 2238 bp

>NTDB_id=111594 HAS68_RS02910 WP_009909666.1 547465..549702(+) (comEC/celB) [Streptococcus suis 05HAS68]
ATGTCACGGTTGAGTAAGCTCCCCTGCCAGCCCGTTCACCTGGCAGTCTTGGCGGTGGCGGCCTACTTTGCAGTCCATTC
TTTTTCCCTCTTGACAATGGGCCTGTTCAGTCTGTTACTGGCTGTCTTTGGTGTTCGGCAAGGTAAGACGGTTTTCCTCA
AAACGCTGCCGCTTTTAGCTCTATGTGGTCTCTTTTTCGGCTACCAAAAGGTCCAATGGGAGCGGGCAGACCAGTCAGCC
ACAGAGCAAGTCACAACTGTGCAGGTCATTCCAGATACTATTGACATTAACGGGGACAGCCTGTCTTTTCGTGGTCGGGC
TGACGGACAAACCTATCAGGTTTTCTATAAATTAACCAGTCAGGAGGAACAGACCTATTTTCAAAAGCTGACAGGTTTGG
TCCAGCTTGAAGTGGAAGCAGAGATCAGTCTGCCAGCTGGTCAGCGGAATTTCAAGGGTTTTGACTATCAGGCCTACCTG
AAAACACAGGGTATTTATCGGACGGTCAAGATTACGGCAATCAAGAAGATTGTCCCAGTCCAGTCTTGGAATGTCTTTGA
CTGGTTGTCAAACTGGCGGAGGCAGGCTTTGGTTTATGTCAAAACCAATTTTCCGGCTCCCATGAGCCACTACATGACAG
GGCTCTTGTTTGGGGACTTGGATAGTGATTTTGACCAGATGAGTGACCTCTATTCCAGTTTGGGTATCATTCATCTCTTT
GCCCTGTCTGGTATGCAGGTGGGCTTTGTCATCGACAAGTTTCGCTGGATTTTACTGCGTTTGGGCTTGACCAAAGAAAC
GGTTGATAAATTACAAATTCCCTTTTCCCTTGTCTATGCGAGCTTGACAGGTTTTTCCGTATCGGTGGTGCGGTCTTTGG
TTCAAAAAATTTTGGGTAATCTGGGCTTGCGGAAGTTGGATAACTTTGCGGTGACAGTTTTTGTCTGTCTGTTGATACTG
CCCCGATTTCTGCTGACAGCTGGTGGTGTCCTGACCTTTACCTATGCTTTTTTGCTGACGGTTTTTGATTTTGAGGACTT
GGGGCAGGTCAAAAAGGCTGCGGTGGAAAGTCTCAGTATTTCACTTGGGATTTTGCCAGTGCTCATGACCTATTTCTATG
CCTTTCAGCCCCTGTCTATCCTCTTGACCTTTGCCTTTTCTTTTGTCTTTGATGTCCTACTCTTGCCAGGCTTGTCAGTC
ATTTTTCTCCTGTCGCCAATCGTCAAGATTACTTGGGTCAACGGATTTTTTGTCTTTATGGAAAAAATCATTGTCTGGGT
GGCGGATTTGGGATTGCGACCTTGGATACTGGGCAAGCCGTCTGAGCTGGTCCTTTTGCTCTTGCTGGTCAGCCTCTTCT
TACTCTACGATTTCCACAGGAGAAAGAAATGGCTTCTAGGACTGAGCTTGGTCCTCGCTCTGCTATTTTTCATAACCAAA
CACCCGCTGGAAAACGAGGTGACGGTGGTGGACATCGGGCAGGGGGACAGCATCTTTTTGCGGGATATGCGGGGGCGGAC
GGTCCTGATTGATGTGGGCGGACGAGTTGATTTTGCGGCCAAGGAAGCGTGGCAGGAGCGGCCTCGGCAGGCAAATGCAG
AGCGGACTTTGATTCCCTATCTGCATAGTCGGGGTGTGGATAGGATTGATAGTTTAGTCCTGACCCACACCGACACAGAC
CATGTGGGGGATGTGCTGGAAGTGGCGAAGCAGGTCCAGATTGGTCGGATTTACGTGTCGCCGGGAAGCCTGACGGTGCC
TGACTTTGTAGCCACCTTGAAAGAAATTAATGTCCCTGTTCATGTTGTTGAGGTGGGCGAACGCTTACCAATTTTTGACT
CTTACCTGGAAGTCCTTTATCCAGATGGGACAGGAGACGGTGGCAATAATGACTCCATTGTCCTTTATGGTCGCTTGCTG
AAAACTAATTTTCTCTTTACAGGGGACTTGGAGCAGGGGGAGTTGGACTTGATAGAATCTTATCCTAACCTGCCTGTCGA
TGTCCTCAAAGCCGGTCACCACGGCTCCAAAGGTTCTTCCTATCCTGAATTTTTGGACCATATCGAAGCCAAGATTGCCT
TGGTATCTGCTGGAGAAAACAACCGCTACAAGCATCCTCACCAAGAAACCTTGGAACGATTTGATAGTCGCAATATCCAA
GTCTATCGTACAGACCAGCAAGGAGCCATTCGCTTCCGAGGTTGGAGGGAGTGGAGGATTGAAACGGTGAGGAGGTAA

Domains

Predicted by InterproScan.

• Competence protein (Competence) (215-461)

• Domain of unknown function (DUF4131) (DUF4131) (29-175)

• Metallo-beta-lactamase superfamily (Lactamase_B) (493-698)

3D structure

• AlphaFold DB: A0A7Y6RP41

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis SK321	53.992	99.195	0.536
comEC/celB	Streptococcus mitis NCTC 12261	52.861	98.523	0.521
comEC/celB	Streptococcus pneumoniae TIGR4	51.973	98.658	0.513
comEC/celB	Streptococcus pneumoniae Rx1	51.701	98.658	0.51
comEC/celB	Streptococcus pneumoniae D39	51.701	98.658	0.51
comEC/celB	Streptococcus pneumoniae R6	51.701	98.658	0.51
comEC	Lactococcus lactis subsp. cremoris KW2	48.865	100	0.491