Detailed information NTG1114606

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: A66_RS09480
• Genome accession: NZ_LN847353
• Coordinates: 1798625..1799332 (+)
• Length: 235 a.a.
• NCBI ID: WP_000166478.1
• Uniprot ID: A0A654UWX8
• Organism: Streptococcus pneumoniae strain A66
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	1797511..1797900	1798625..1799332	flank	725

Gene organization within MGE regions

Location: 1797511..1799332

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A66_RS09470 (A66_01886)	-	1797511..1798070 (-)	560	Protein_1837	transposase family protein	-
A66_RS09475 (A66_01887)	-	1798056..1798541 (+)	486	WP_050155278.1	cupin domain-containing protein	-
A66_RS09480 (A66_01888)	vicR	1798625..1799332 (+)	708	WP_000166478.1	response regulator transcription factor	Regulator

Sequence

Protein

• Length: 235 a.a.
• Molecular weight: 27240.59 Da
• Isoelectric Point: 6.6568

>NTDB_id=1114606 A66_RS09480 WP_000166478.1 1798625..1799332(+) (vicR) [Streptococcus pneumoniae strain A66]
MTKQVLLVDDEEHILRLLDYHLSKEGFSTQLVTNGRKALALAETEPFDFILLDIMLPQLDGIEVCKRLRAKGVKTPIMMV
SAKSDEFDKVLALELGADDYLTKPFSPRELLARVKAVLRRTKGEQEGDDSDNIADDSWLFGTLKVYPERHEVYKANKLLS
LTPKEFELLLYLMKHPNMTLTRERLLERIWGYDFGQETRLVDVHIGKLREKIEDNPKAPQFIRTIRGYGYKFKEL

Nucleotide

• Length: 708 bp

>NTDB_id=1114606 A66_RS09480 WP_000166478.1 1798625..1799332(+) (vicR) [Streptococcus pneumoniae strain A66]
ATGACAAAACAAGTCTTATTAGTGGATGATGAAGAACACATTCTGAGATTGCTTGACTACCATTTAAGTAAGGAAGGCTT
TTCTACTCAATTGGTAACAAATGGACGGAAGGCCTTAGCTTTGGCAGAAACAGAACCCTTTGATTTTATCTTGCTTGATA
TCATGTTACCACAATTAGATGGCATAGAAGTTTGTAAGCGGCTGAGAGCCAAAGGCGTCAAAACTCCAATTATGATGGTT
TCTGCGAAAAGTGATGAATTTGATAAGGTTTTGGCCTTGGAATTAGGGGCTGATGACTACCTGACCAAGCCTTTTAGCCC
TAGAGAATTGCTGGCGCGTGTCAAGGCTGTCCTCAGGCGAACTAAAGGAGAACAAGAAGGAGATGATTCAGATAATATCG
CTGACGATTCTTGGCTATTTGGGACCTTGAAAGTATACCCTGAGCGTCATGAAGTCTACAAGGCGAATAAGTTACTGAGT
TTGACCCCAAAAGAATTTGAACTCTTGCTCTATCTTATGAAACATCCCAACATGACACTGACTAGAGAGCGTCTTTTGGA
ACGTATCTGGGGGTATGACTTTGGGCAGGAAACACGTTTGGTGGACGTTCATATTGGTAAGTTGAGGGAAAAAATTGAAG
ACAATCCTAAAGCCCCTCAATTTATTCGAACCATTCGGGGTTATGGTTATAAGTTCAAGGAGTTATAG

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (5-115)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (159-232)

3D structure

• AlphaFold DB: A0A654UWX8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	48.707	98.723	0.481
micA	Streptococcus pneumoniae Cp1015	47.845	98.723	0.472
covR	Lactococcus lactis subsp. lactis strain DGCC12653	41.202	99.149	0.409
covR	Streptococcus salivarius strain HSISS4	40.171	99.574	0.4