Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   A66_RS02420 Genome accession   NZ_LN847353
Coordinates   458835..459572 (+) Length   245 a.a.
NCBI ID   WP_001219121.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain A66     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 453835..464572
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A66_RS12100 (A66_00476) - 454935..455111 (-) 177 WP_014931964.1 hypothetical protein -
  A66_RS02390 (A66_00477) - 455273..455560 (-) 288 WP_000777751.1 hypothetical protein -
  A66_RS02395 (A66_00478) - 455570..455980 (-) 411 WP_001278301.1 HIT family protein -
  A66_RS02400 (A66_00479) pptA 456048..456779 (+) 732 WP_000889919.1 ABC transporter ATP-binding protein Regulator
  A66_RS02405 (A66_00480) - 456776..457825 (+) 1050 WP_000653777.1 ABC transporter permease -
  A66_RS02410 (A66_00481) - 457886..458215 (-) 330 WP_000132573.1 hypothetical protein -
  A66_RS02415 (A66_00482) - 458492..458830 (+) 339 WP_000682133.1 LytTR family DNA-binding domain-containing protein -
  A66_RS02420 (A66_00483) comE/blpR 458835..459572 (+) 738 WP_001219121.1 response regulator transcription factor Regulator
  A66_RS02425 (A66_00484) - 459586..460926 (+) 1341 WP_053039477.1 sensor histidine kinase -
  A66_RS02430 (A66_00485) blpC 460997..461125 (-) 129 WP_000358815.1 quorum-sensing system pheromone BlpC -
  A66_RS02435 (A66_00486) - 461182..462543 (-) 1362 WP_001069075.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28740.91 Da        Isoelectric Point: 6.4140

>NTDB_id=1114557 A66_RS02420 WP_001219121.1 458835..459572(+) (comE/blpR) [Streptococcus pneumoniae strain A66]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=1114557 A66_RS02420 WP_001219121.1 458835..459572(+) (comE/blpR) [Streptococcus pneumoniae strain A66]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGACATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGATCGGGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCTCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGTTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.321

99.184

0.539
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

38.43

98.776

0.38

Multiple sequence alignment