Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   AT689_RS05025 Genome accession   NZ_LN831051
Coordinates   926954..927613 (-) Length   219 a.a.
NCBI ID   WP_000565020.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain NCTC7465     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 909349..934330 926954..927613 within 0


Gene organization within MGE regions


Location: 909349..934330
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AT689_RS04930 (ERS445053_00962) - 909349..909645 (+) 297 WP_000239024.1 hypothetical protein -
  AT689_RS11620 - 909881..910195 (+) 315 Protein_917 GDP-mannose 4,6-dehydratase -
  AT689_RS04935 (ERS445053_00963) - 910359..911018 (+) 660 WP_000793805.1 DUF1868 domain-containing protein -
  AT689_RS04940 (ERS445053_00964) - 911043..912110 (+) 1068 WP_000738361.1 extracellular solute-binding protein -
  AT689_RS04945 (ERS445053_00965) - 912214..913224 (+) 1011 WP_000589142.1 ABC transporter ATP-binding protein -
  AT689_RS04950 (ERS445053_00966) - 913236..914927 (+) 1692 WP_001216185.1 iron ABC transporter permease -
  AT689_RS04955 (ERS445053_00967) - 914930..915640 (+) 711 WP_000127552.1 MgtC/SapB family protein -
  AT689_RS04960 (ERS445053_00968) - 915736..916104 (+) 369 WP_000656285.1 hypothetical protein -
  AT689_RS04965 (ERS445053_00969) - 916212..917213 (+) 1002 WP_000789949.1 LacI family DNA-binding transcriptional regulator -
  AT689_RS12970 - 917884..918072 (+) 189 WP_033684682.1 hypothetical protein -
  AT689_RS04980 (ERS445053_00972) trpE 918444..919805 (+) 1362 WP_000439604.1 anthranilate synthase component I -
  AT689_RS04985 (ERS445053_00973) - 919802..920368 (+) 567 WP_000601920.1 aminodeoxychorismate/anthranilate synthase component II -
  AT689_RS04990 (ERS445053_00974) trpD 920379..921383 (+) 1005 WP_000658684.1 anthranilate phosphoribosyltransferase -
  AT689_RS04995 (ERS445053_00975) trpC 921380..922147 (+) 768 WP_000076553.1 indole-3-glycerol phosphate synthase TrpC -
  AT689_RS05000 (ERS445053_00976) - 922134..922733 (+) 600 WP_000169907.1 phosphoribosylanthranilate isomerase -
  AT689_RS05005 (ERS445053_00977) trpB 922711..923934 (+) 1224 WP_000331296.1 tryptophan synthase subunit beta -
  AT689_RS05010 (ERS445053_00978) trpA 923927..924703 (+) 777 WP_001126994.1 tryptophan synthase subunit alpha -
  AT689_RS11625 - 924675..924785 (-) 111 Protein_933 prepilin peptidase -
  AT689_RS05015 (ERS445053_00980) - 925005..925736 (+) 732 Protein_934 hypothetical protein -
  AT689_RS05020 (ERS445053_00981) - 925751..926902 (+) 1152 WP_000481760.1 XRE family transcriptional regulator -
  AT689_RS05025 (ERS445053_00982) cclA/cilC 926954..927613 (-) 660 WP_000565020.1 A24 family peptidase Machinery gene
  AT689_RS05030 (ERS445053_00983) - 927683..928129 (+) 447 WP_000155418.1 GNAT family N-acetyltransferase -
  AT689_RS05035 (ERS445053_00984) - 928357..929535 (-) 1179 WP_000175875.1 ROK family transcriptional regulator -
  AT689_RS05040 (ERS445053_00985) - 929815..931077 (+) 1263 WP_000413336.1 PTS sugar transporter subunit IIC -
  AT689_RS05045 (ERS445053_00986) - 931080..931976 (+) 897 WP_000825669.1 PEP phosphonomutase -
  AT689_RS05050 (ERS445053_00987) - 931981..933666 (+) 1686 WP_000791290.1 family 16 glycosylhydrolase -
  AT689_RS05055 (ERS445053_00988) - 933679..933996 (+) 318 WP_001151646.1 PTS sugar transporter subunit IIB -
  AT689_RS05060 (ERS445053_00989) - 934013..934330 (+) 318 WP_000344534.1 PTS lactose/cellobiose transporter subunit IIA -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24869.01 Da        Isoelectric Point: 7.9575

>NTDB_id=1114389 AT689_RS05025 WP_000565020.1 926954..927613(-) (cclA/cilC) [Streptococcus pneumoniae strain NCTC7465]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACLIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=1114389 AT689_RS05025 WP_000565020.1 926954..927613(-) (cclA/cilC) [Streptococcus pneumoniae strain NCTC7465]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTAGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGAGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATTCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae Rx1

97.26

100

0.973
  cclA/cilC Streptococcus pneumoniae D39

97.26

100

0.973
  cclA/cilC Streptococcus pneumoniae R6

97.26

100

0.973
  cclA/cilC Streptococcus pneumoniae TIGR4

96.347

100

0.963
  cclA/cilC Streptococcus mitis SK321

92.694

100

0.927
  cclA/cilC Streptococcus mitis NCTC 12261

87.215

100

0.872

Multiple sequence alignment