Detailed information NTG1114199

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: B6D67_RS00325
• Genome accession: NZ_LN831034
• Coordinates: 53094..54005 (+)
• Length: 303 a.a.
• NCBI ID: WP_029714263.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC8198
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48094..59005

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
B6D67_RS00305 (ERS445054_00058)	purE	48431..48922 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
B6D67_RS00310 (ERS445054_00059)	purK	48909..49982 (+)	1074	WP_029714261.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
B6D67_RS00315 (ERS445054_00060)	-	50009..51652 (+)	1644	WP_010921779.1	AIPR family protein	-
B6D67_RS00320 (ERS445054_00061)	purB	51670..52962 (+)	1293	WP_010921780.1	adenylosuccinate lyase	-
B6D67_RS00325 (ERS445054_00062)	comR	53094..54005 (+)	912	WP_029714263.1	transcriptional regulator Rgg4/ComR	Regulator
B6D67_RS10600 (ERS445054_00063)	comS	54089..54184 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
B6D67_RS00330 (ERS445054_00064)	ruvB	54231..55229 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
B6D67_RS00335 (ERS445054_00065)	-	55367..55804 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
B6D67_RS00340 (ERS445054_00066)	-	55827..56228 (+)	402	WP_010921781.1	MORN repeat-containing protein	-
B6D67_RS00345 (ERS445054_00067)	-	56225..58000 (+)	1776	WP_010921782.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35787.30 Da
• Isoelectric Point: 4.4858

>NTDB_id=1114199 B6D67_RS00325 WP_029714263.1 53094..54005(+) (comR) [Streptococcus pyogenes strain NCTC8198]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQTTLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=1114199 B6D67_RS00325 WP_029714263.1 53094..54005(+) (comR) [Streptococcus pyogenes strain NCTC8198]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGACAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (73-296)

• Helix-turn-helix (HTH_3) (12-64)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	99.67	100	0.997
comR	Streptococcus pyogenes MGAS315	58.14	99.34	0.578
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462