Detailed information NTG0107177

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: AAA995_RS02580
• Genome accession: NZ_AP028877
• Coordinates: 501533..502270 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219120.1
• Uniprot ID: Q9S1I6
• Organism: Streptococcus pneumoniae strain 21P20
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 496533..507270

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AAA995_RS02545 (SP21P20_04980)	-	497463..497702 (-)	240	WP_001810235.1	hypothetical protein	-
AAA995_RS02550 (SP21P20_04990)	-	497864..498151 (-)	288	WP_000777760.1	hypothetical protein	-
AAA995_RS02555 (SP21P20_05000)	-	498161..498571 (-)	411	WP_001278299.1	HIT family protein	-
AAA995_RS02560 (SP21P20_05010)	pptA	498639..499370 (+)	732	WP_000889925.1	ABC transporter ATP-binding protein	Regulator
AAA995_RS02565 (SP21P20_05020)	-	499367..500416 (+)	1050	WP_000653767.1	ABC transporter permease	-
AAA995_RS02570 (SP21P20_05030)	-	500584..500913 (-)	330	WP_000132572.1	hypothetical protein	-
AAA995_RS02575 (SP21P20_05040)	-	501190..501528 (+)	339	WP_000682135.1	LytTR family DNA-binding domain-containing protein	-
AAA995_RS02580 (SP21P20_05050)	comE/blpR	501533..502270 (+)	738	WP_001219120.1	LytTR family DNA-binding domain-containing protein	Regulator
AAA995_RS02585 (SP21P20_05060)	-	502284..503624 (+)	1341	WP_054372059.1	sensor histidine kinase	-
AAA995_RS02590 (SP21P20_05070)	blpC	503666..503821 (-)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
AAA995_RS02595 (SP21P20_05080)	-	503878..505239 (-)	1362	WP_001069091.1	bacteriocin secretion accessory protein	-
AAA995_RS02600 (SP21P20_05090)	comA/nlmT	505250..506926 (-)	1677	WP_196299874.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28754.98 Da
• Isoelectric Point: 6.5884

>NTDB_id=107177 AAA995_RS02580 WP_001219120.1 501533..502270(+) (comE/blpR) [Streptococcus pneumoniae strain 21P20]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=107177 AAA995_RS02580 WP_001219120.1 501533..502270(+) (comE/blpR) [Streptococcus pneumoniae strain 21P20]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: Q9S1I6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	38.017	98.776	0.376
comE	Streptococcus infantis strain Atu-4	35.887	100	0.363