Detailed information
Bioinformatically predicted
Overview
| Name | cclA/cilC | Type | Machinery gene |
| Locus tag | ACIVIR_RS10325 | Genome accession | NZ_CP173225 |
| Coordinates | 2007008..2007667 (+) | Length | 219 a.a. |
| NCBI ID | WP_000565001.1 | Uniprot ID | A0A0B7M7B9 |
| Organism | Streptococcus pneumoniae strain 262 | ||
| Function | processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake |
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Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Genomic island | 1997186..2030599 | 2007008..2007667 | within | 0 |
Gene organization within MGE regions
Location: 1997186..2030599
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ACIVIR_RS10275 | - | 1997186..1997956 (-) | 771 | WP_000229339.1 | sulfite exporter TauE/SafE family protein | - |
| ACIVIR_RS10280 | - | 1997971..1998819 (-) | 849 | WP_000782429.1 | formylglycine-generating enzyme family protein | - |
| ACIVIR_RS10285 | - | 1998816..2000291 (-) | 1476 | WP_050096564.1 | arylsulfatase | - |
| ACIVIR_RS10290 | - | 2000614..2001969 (-) | 1356 | WP_001865112.1 | PTS sugar transporter subunit IIC | - |
| ACIVIR_RS10295 | - | 2001979..2002296 (-) | 318 | WP_001005887.1 | PTS lactose/cellobiose transporter subunit IIA | - |
| ACIVIR_RS10300 | - | 2002313..2002630 (-) | 318 | WP_050221104.1 | PTS sugar transporter subunit IIB | - |
| ACIVIR_RS10305 | - | 2002645..2003541 (-) | 897 | WP_001865114.1 | hypothetical protein | - |
| ACIVIR_RS10310 | - | 2003544..2004806 (-) | 1263 | WP_000413342.1 | PTS sugar transporter subunit IIC | - |
| ACIVIR_RS10315 | - | 2005086..2006264 (+) | 1179 | WP_001865373.1 | ROK family transcriptional regulator | - |
| ACIVIR_RS10320 | - | 2006492..2006938 (-) | 447 | WP_000155432.1 | GNAT family N-acetyltransferase | - |
| ACIVIR_RS10325 | cclA/cilC | 2007008..2007667 (+) | 660 | WP_000565001.1 | A24 family peptidase | Machinery gene |
| ACIVIR_RS10330 | - | 2007719..2008870 (-) | 1152 | WP_001865397.1 | XRE family transcriptional regulator | - |
| ACIVIR_RS10335 | - | 2008885..2009616 (-) | 732 | WP_000934016.1 | hypothetical protein | - |
| ACIVIR_RS10340 | - | 2009836..2009946 (+) | 111 | Protein_2002 | prepilin peptidase | - |
| ACIVIR_RS10345 | trpA | 2009918..2010694 (-) | 777 | WP_001127027.1 | tryptophan synthase subunit alpha | - |
| ACIVIR_RS10350 | trpB | 2010687..2011910 (-) | 1224 | WP_024477621.1 | tryptophan synthase subunit beta | - |
| ACIVIR_RS10355 | - | 2011888..2012487 (-) | 600 | WP_000169888.1 | phosphoribosylanthranilate isomerase | - |
| ACIVIR_RS10360 | trpC | 2012474..2013241 (-) | 768 | WP_000076548.1 | indole-3-glycerol phosphate synthase TrpC | - |
| ACIVIR_RS10365 | trpD | 2013238..2014242 (-) | 1005 | WP_000658682.1 | anthranilate phosphoribosyltransferase | - |
| ACIVIR_RS10370 | - | 2014253..2014819 (-) | 567 | WP_000601919.1 | aminodeoxychorismate/anthranilate synthase component II | - |
| ACIVIR_RS10375 | trpE | 2014816..2016177 (-) | 1362 | WP_000439654.1 | anthranilate synthase component I | - |
| ACIVIR_RS10380 | - | 2016549..2016737 (-) | 189 | WP_185739684.1 | hypothetical protein | - |
| ACIVIR_RS10385 | - | 2017407..2018408 (-) | 1002 | WP_000789949.1 | LacI family DNA-binding transcriptional regulator | - |
| ACIVIR_RS10390 | - | 2018516..2018884 (-) | 369 | WP_000656286.1 | hypothetical protein | - |
| ACIVIR_RS10395 | - | 2018980..2019690 (-) | 711 | WP_000127552.1 | MgtC/SapB family protein | - |
| ACIVIR_RS10400 | - | 2019693..2021384 (-) | 1692 | WP_001216185.1 | iron ABC transporter permease | - |
| ACIVIR_RS10405 | - | 2021396..2022406 (-) | 1011 | WP_050279185.1 | ABC transporter ATP-binding protein | - |
| ACIVIR_RS10410 | - | 2022510..2023577 (-) | 1068 | WP_023930326.1 | extracellular solute-binding protein | - |
| ACIVIR_RS10415 | - | 2023602..2024261 (-) | 660 | WP_000793812.1 | DUF1868 domain-containing protein | - |
| ACIVIR_RS10420 | galE | 2024441..2025451 (-) | 1011 | WP_050198011.1 | UDP-glucose 4-epimerase GalE | - |
| ACIVIR_RS10425 | galT | 2025464..2026939 (-) | 1476 | WP_000848795.1 | UDP-glucose--hexose-1-phosphate uridylyltransferase | - |
| ACIVIR_RS10430 | - | 2026957..2027592 (-) | 636 | WP_050084685.1 | phosphate uptake regulator PhoU | - |
| ACIVIR_RS10435 | - | 2027650..2028033 (-) | 384 | WP_001812628.1 | hypothetical protein | - |
| ACIVIR_RS10440 | - | 2028193..2028489 (-) | 297 | WP_000239027.1 | hypothetical protein | - |
Sequence
Protein
Download Length: 219 a.a. Molecular weight: 24820.92 Da Isoelectric Point: 7.2761
>NTDB_id=1070830 ACIVIR_RS10325 WP_000565001.1 2007008..2007667(+) (cclA/cilC) [Streptococcus pneumoniae strain 262]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTPLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLLV
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTPLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLLV
Nucleotide
Download Length: 660 bp
>NTDB_id=1070830 ACIVIR_RS10325 WP_000565001.1 2007008..2007667(+) (cclA/cilC) [Streptococcus pneumoniae strain 262]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTAGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCCCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
ATACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATTGATATCCGCATGGGTGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTAGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCCCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
ATACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATTGATATCCGCATGGGTGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| cclA/cilC | Streptococcus pneumoniae TIGR4 |
98.174 |
100 |
0.982 |
| cclA/cilC | Streptococcus pneumoniae Rx1 |
96.804 |
100 |
0.968 |
| cclA/cilC | Streptococcus pneumoniae D39 |
96.804 |
100 |
0.968 |
| cclA/cilC | Streptococcus pneumoniae R6 |
96.804 |
100 |
0.968 |
| cclA/cilC | Streptococcus mitis SK321 |
92.237 |
100 |
0.922 |
| cclA/cilC | Streptococcus mitis NCTC 12261 |
87.215 |
100 |
0.872 |