Detailed information NTG0106291

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: AABA14_RS08835
• Genome accession: NZ_AP028607
• Coordinates: 1716842..1717501 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565023.1
• Uniprot ID: A0A0I8D2P0
• Organism: Streptococcus pneumoniae strain Sep2
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1711842..1722501

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AABA14_RS08810 (TKY123642_17540)	-	1712147..1712464 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
AABA14_RS08815 (TKY123642_17550)	-	1712479..1713375 (-)	897	WP_050198591.1	PEP phosphonomutase	-
AABA14_RS08820 (TKY123642_17560)	-	1713378..1714640 (-)	1263	WP_338168401.1	PTS sugar transporter subunit IIC	-
AABA14_RS08825 (TKY123642_17570)	-	1714920..1716098 (+)	1179	WP_000175880.1	ROK family transcriptional regulator	-
AABA14_RS08830 (TKY123642_17580)	-	1716374..1716772 (-)	399	WP_050102521.1	GNAT family N-acetyltransferase	-
AABA14_RS08835 (TKY123642_17590)	cclA/cilC	1716842..1717501 (+)	660	WP_000565023.1	A24 family peptidase	Machinery gene
AABA14_RS08840 (TKY123642_17600)	trpA	1717473..1718249 (-)	777	WP_001126995.1	tryptophan synthase subunit alpha	-
AABA14_RS08845 (TKY123642_17610)	trpB	1718242..1719465 (-)	1224	WP_000331298.1	tryptophan synthase subunit beta	-
AABA14_RS08850 (TKY123642_17620)	-	1719443..1720042 (-)	600	WP_000169872.1	phosphoribosylanthranilate isomerase	-
AABA14_RS08855 (TKY123642_17630)	trpC	1720029..1720796 (-)	768	WP_000076544.1	indole-3-glycerol phosphate synthase TrpC	-
AABA14_RS08860 (TKY123642_17640)	trpD	1720793..1721797 (-)	1005	WP_000658684.1	anthranilate phosphoribosyltransferase	-
AABA14_RS08865 (TKY123642_17650)	-	1721808..1722374 (-)	567	WP_000601926.1	aminodeoxychorismate/anthranilate synthase component II	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24921.13 Da
• Isoelectric Point: 8.2409

>NTDB_id=106291 AABA14_RS08835 WP_000565023.1 1716842..1717501(+) (cclA/cilC) [Streptococcus pneumoniae strain Sep2]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWKLLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=106291 AABA14_RS08835 WP_000565023.1 1716842..1717501(+) (cclA/cilC) [Streptococcus pneumoniae strain Sep2]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGAAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0I8D2P0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae TIGR4	97.717	100	0.977
cclA/cilC	Streptococcus pneumoniae Rx1	96.347	100	0.963
cclA/cilC	Streptococcus pneumoniae D39	96.347	100	0.963
cclA/cilC	Streptococcus pneumoniae R6	96.347	100	0.963
cclA/cilC	Streptococcus mitis SK321	92.237	100	0.922
cclA/cilC	Streptococcus mitis NCTC 12261	86.301	100	0.863