Detailed information NTG0106210

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: AAA996_RS08470
• Genome accession: NZ_AP028606
• Coordinates: 1669712..1670371 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565010.1
• Uniprot ID: A0A0B7M2C6
• Organism: Streptococcus pneumoniae strain Sep1
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1664712..1675371

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AAA996_RS08445 (TKY121773_16720)	-	1665017..1665334 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
AAA996_RS08450 (TKY121773_16730)	-	1665349..1666245 (-)	897	WP_000825669.1	PEP phosphonomutase	-
AAA996_RS08455 (TKY121773_16740)	-	1666248..1667510 (-)	1263	WP_000413345.1	PTS sugar transporter subunit IIC	-
AAA996_RS08460 (TKY121773_16750)	-	1667790..1668968 (+)	1179	WP_000175876.1	ROK family transcriptional regulator	-
AAA996_RS08465 (TKY121773_16760)	-	1669196..1669642 (-)	447	WP_000155418.1	GNAT family N-acetyltransferase	-
AAA996_RS08470 (TKY121773_16770)	cclA/cilC	1669712..1670371 (+)	660	WP_000565010.1	A24 family peptidase	Machinery gene
AAA996_RS08475 (TKY121773_16780)	trpA	1670343..1671119 (-)	777	WP_001126994.1	tryptophan synthase subunit alpha	-
AAA996_RS08480 (TKY121773_16790)	trpB	1671112..1672335 (-)	1224	WP_000331292.1	tryptophan synthase subunit beta	-
AAA996_RS08485 (TKY121773_16800)	-	1672313..1672912 (-)	600	WP_317640055.1	phosphoribosylanthranilate isomerase	-
AAA996_RS08490 (TKY121773_16810)	trpC	1672899..1673666 (-)	768	WP_000076558.1	indole-3-glycerol phosphate synthase TrpC	-
AAA996_RS08495 (TKY121773_16820)	trpD	1673663..1674667 (-)	1005	WP_000658684.1	anthranilate phosphoribosyltransferase	-
AAA996_RS08500 (TKY121773_16830)	-	1674678..1675244 (-)	567	WP_000601927.1	aminodeoxychorismate/anthranilate synthase component II	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24845.99 Da
• Isoelectric Point: 7.5762

>NTDB_id=106210 AAA996_RS08470 WP_000565010.1 1669712..1670371(+) (cclA/cilC) [Streptococcus pneumoniae strain Sep1]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFCCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLSQVILITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=106210 AAA996_RS08470 WP_000565010.1 1669712..1670371(+) (cclA/cilC) [Streptococcus pneumoniae strain Sep1]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTTGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTACTTTCCTTGAGTCAAGTCATCCTAATCACTGCTGGTTTGACCTTGGGTAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTT
TTTTTAGCTTCTTGCGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0B7M2C6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae Rx1	100	100	1
cclA/cilC	Streptococcus pneumoniae D39	100	100	1
cclA/cilC	Streptococcus pneumoniae R6	100	100	1
cclA/cilC	Streptococcus pneumoniae TIGR4	94.977	100	0.95
cclA/cilC	Streptococcus mitis SK321	92.694	100	0.927
cclA/cilC	Streptococcus mitis NCTC 12261	87.671	100	0.877