Detailed information NTG0106136

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: AAA990_RS08255
• Genome accession: NZ_AP028605
• Coordinates: 1619780..1620439 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565021.1
• Uniprot ID: C1C962
• Organism: Streptococcus pneumoniae strain Pne4
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1614780..1625439

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AAA990_RS08230 (TKY183112_16250)	-	1615085..1615402 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
AAA990_RS08235 (TKY183112_16260)	-	1615417..1616313 (-)	897	WP_000825669.1	PEP phosphonomutase	-
AAA990_RS08240 (TKY183112_16270)	-	1616316..1617578 (-)	1263	WP_000413335.1	PTS sugar transporter subunit IIC	-
AAA990_RS08245 (TKY183112_16280)	-	1617858..1619036 (+)	1179	WP_000175875.1	ROK family transcriptional regulator	-
AAA990_RS08250 (TKY183112_16290)	-	1619264..1619710 (-)	447	WP_000155418.1	GNAT family N-acetyltransferase	-
AAA990_RS08255 (TKY183112_16300)	cclA/cilC	1619780..1620439 (+)	660	WP_000565021.1	A24 family peptidase	Machinery gene
AAA990_RS08260 (TKY183112_16310)	-	1620491..1621642 (-)	1152	WP_000481760.1	XRE family transcriptional regulator	-
AAA990_RS08265 (TKY183112_16320)	-	1621657..1622388 (-)	732	Protein_1635	hypothetical protein	-
AAA990_RS08270	-	1622617..1622718 (+)	102	Protein_1636	prepilin peptidase	-
AAA990_RS08275 (TKY183112_16340)	trpA	1622690..1623466 (-)	777	WP_001127048.1	tryptophan synthase subunit alpha	-
AAA990_RS08280 (TKY183112_16350)	trpB	1623459..1624682 (-)	1224	WP_000331289.1	tryptophan synthase subunit beta	-
AAA990_RS08285 (TKY183112_16360)	-	1624660..1625259 (-)	600	WP_000169887.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24854.98 Da
• Isoelectric Point: 7.9575

>NTDB_id=106136 AAA990_RS08255 WP_000565021.1 1619780..1620439(+) (cclA/cilC) [Streptococcus pneumoniae strain Pne4]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLAACVIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=106136 AAA990_RS08255 WP_000565021.1 1619780..1620439(+) (cclA/cilC) [Streptococcus pneumoniae strain Pne4]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTAGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGAGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATTCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTGCTTGTGTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: C1C962

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae Rx1	97.717	100	0.977
cclA/cilC	Streptococcus pneumoniae D39	97.717	100	0.977
cclA/cilC	Streptococcus pneumoniae R6	97.717	100	0.977
cclA/cilC	Streptococcus pneumoniae TIGR4	95.89	100	0.959
cclA/cilC	Streptococcus mitis SK321	93.151	100	0.932
cclA/cilC	Streptococcus mitis NCTC 12261	87.671	100	0.877