Detailed information NTG0105932

Bioinformatically predicted

Overview

• Name: comC/comC2
• Type: Regulator
• Locus tag: AABA08_RS10465
• Genome accession: NZ_AP028602
• Coordinates: 2047098..2047223 (-)
• Length: 41 a.a.
• NCBI ID: WP_000799686.1
• Uniprot ID: P60242
• Organism: Streptococcus pneumoniae strain PF2
• Function: binding to ComD; induce autophosphorylation of ComD (predicted from homology) Competence regulation

Genomic Context

Location: 2042098..2052223

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AABA08_RS10435	-	2042479..2044090 (-)	1612	Protein_2018	YhgE/Pip family protein	-
AABA08_RS10440 (TKY092604_20210)	-	2044218..2044760 (+)	543	WP_001158263.1	TetR/AcrR family transcriptional regulator	-
AABA08_RS10455 (TKY092604_20220)	comE	2045003..2045755 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
AABA08_RS10460 (TKY092604_20230)	comD/comD2	2045752..2047077 (-)	1326	WP_001842237.1	competence system sensor histidine kinase ComD	Regulator
AABA08_RS10465	comC/comC2	2047098..2047223 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
AABA08_RS10475 (TKY092604_20240)	rlmH	2047505..2047984 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
AABA08_RS10480 (TKY092604_20250)	htrA	2048167..2049348 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
AABA08_RS10485 (TKY092604_20260)	spo0J	2049406..2050164 (+)	759	WP_000410380.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 41 a.a.
• Molecular weight: 4907.00 Da
• Isoelectric Point: 11.0006

>NTDB_id=105932 AABA08_RS10465 WP_000799686.1 2047098..2047223(-) (comC/comC2) [Streptococcus pneumoniae strain PF2]
MKNTVKLEQFVALKEKDLQKIKGGEMRISRIILDFLFLRKK

Nucleotide

• Length: 126 bp

>NTDB_id=105932 AABA08_RS10465 WP_000799686.1 2047098..2047223(-) (comC/comC2) [Streptococcus pneumoniae strain PF2]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAAGATTAAAGGTGGGGAGATGAG
GATTTCAAGAATCATCCTTGATTTTCTTTTCCTACGAAAAAAGTAA

Domains

Predicted by InterproScan.

• COMC family (ComC) (1-29)

3D structure

• PDB: 6CJ8
• PDB: 6COO
• PDB: 6COP
• PDB: 6COQ
• PDB: 6COR
• PDB: 6COS
• PDB: 6COW
• PDB: 6OBW
• PDB: 6OC2
• PDB: 6OC4
• PDB: 6OLD
• PDB: 6V1N

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comC/comC2	Streptococcus pneumoniae A66	100	100	1
comC/comC2	Streptococcus pneumoniae TIGR4	100	100	1
comC/comC1	Streptococcus pneumoniae R6	80.488	100	0.805
comC/comC1	Streptococcus pneumoniae G54	80.488	100	0.805
comC/comC1	Streptococcus pneumoniae D39	80.488	100	0.805
comC/comC1	Streptococcus pneumoniae Rx1	80.488	100	0.805
comC	Streptococcus mitis SK321	75.61	100	0.756
comC	Streptococcus mitis NCTC 12261	57.5	97.561	0.561