Detailed information NTG0105896

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: AABA08_RS07935
• Genome accession: NZ_AP028602
• Coordinates: 1582605..1583264 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565023.1
• Uniprot ID: A0A0I8D2P0
• Organism: Streptococcus pneumoniae strain PF2
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1577605..1588264

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AABA08_RS07910 (TKY092604_15700)	-	1577910..1578227 (-)	318	WP_001151646.1	PTS sugar transporter subunit IIB	-
AABA08_RS07915 (TKY092604_15710)	-	1578242..1579138 (-)	897	WP_000825669.1	PEP phosphonomutase	-
AABA08_RS07920 (TKY092604_15720)	-	1579141..1580403 (-)	1263	WP_000413336.1	PTS sugar transporter subunit IIC	-
AABA08_RS07925 (TKY092604_15730)	-	1580683..1581861 (+)	1179	WP_000175880.1	ROK family transcriptional regulator	-
AABA08_RS07930 (TKY092604_15740)	-	1582089..1582535 (-)	447	WP_000155406.1	GNAT family N-acetyltransferase	-
AABA08_RS07935 (TKY092604_15750)	cclA/cilC	1582605..1583264 (+)	660	WP_000565023.1	prepilin peptidase	Machinery gene
AABA08_RS07940 (TKY092604_15760)	trpA	1583236..1584012 (-)	777	WP_001127007.1	tryptophan synthase subunit alpha	-
AABA08_RS07945 (TKY092604_15770)	trpB	1584005..1585228 (-)	1224	WP_000331298.1	tryptophan synthase subunit beta	-
AABA08_RS07950 (TKY092604_15780)	-	1585206..1585805 (-)	600	WP_000169872.1	phosphoribosylanthranilate isomerase	-
AABA08_RS07955 (TKY092604_15790)	trpC	1585792..1586559 (-)	768	WP_000076544.1	indole-3-glycerol phosphate synthase TrpC	-
AABA08_RS07960 (TKY092604_15800)	trpD	1586556..1587560 (-)	1005	WP_000658685.1	anthranilate phosphoribosyltransferase	-
AABA08_RS07965 (TKY092604_15810)	-	1587571..1588137 (-)	567	WP_000601921.1	aminodeoxychorismate/anthranilate synthase component II	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24921.13 Da
• Isoelectric Point: 8.2409

>NTDB_id=105896 AABA08_RS07935 WP_000565023.1 1582605..1583264(+) (cclA/cilC) [Streptococcus pneumoniae strain PF2]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWKLLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=105896 AABA08_RS07935 WP_000565023.1 1582605..1583264(+) (cclA/cilC) [Streptococcus pneumoniae strain PF2]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGAAATTGCTTTCCTTGGGGCAAGTAGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGGGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0I8D2P0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae TIGR4	97.717	100	0.977
cclA/cilC	Streptococcus pneumoniae Rx1	96.347	100	0.963
cclA/cilC	Streptococcus pneumoniae D39	96.347	100	0.963
cclA/cilC	Streptococcus pneumoniae R6	96.347	100	0.963
cclA/cilC	Streptococcus mitis SK321	92.237	100	0.922
cclA/cilC	Streptococcus mitis NCTC 12261	86.301	100	0.863