Detailed information    

insolico Bioinformatically predicted

Overview

Name   micB   Type   Regulator
Locus tag   ACD269_RS05820 Genome accession   NZ_CP168260
Coordinates   1132903..1134252 (-) Length   449 a.a.
NCBI ID   WP_000886210.1    Uniprot ID   A0A064BZM9
Organism   Streptococcus pneumoniae strain FC2     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1127903..1139252
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACD269_RS05795 (ACD269_05795) - 1129437..1130423 (+) 987 WP_000204725.1 L-lactate dehydrogenase -
  ACD269_RS05800 (ACD269_05800) - 1130683..1131456 (-) 774 WP_000731135.1 potassium channel family protein -
  ACD269_RS05805 (ACD269_05805) - 1131503..1131757 (-) 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin -
  ACD269_RS05810 (ACD269_05810) relB 1131759..1132001 (-) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  ACD269_RS05815 (ACD269_05815) vicX 1132092..1132901 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  ACD269_RS05820 (ACD269_05820) micB 1132903..1134252 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  ACD269_RS05825 (ACD269_05825) micA 1134245..1134949 (-) 705 WP_000722076.1 response regulator YycF Regulator
  ACD269_RS05830 (ACD269_05830) mutY 1135004..1136179 (-) 1176 WP_050238751.1 A/G-specific adenine glycosylase -
  ACD269_RS05835 (ACD269_05835) - 1136276..1136401 (+) 126 WP_001818232.1 hypothetical protein -
  ACD269_RS05840 (ACD269_05840) - 1136507..1138177 (-) 1671 WP_000845290.1 formate--tetrahydrofolate ligase -
  ACD269_RS05845 (ACD269_05845) coaB 1138407..1139096 (+) 690 WP_000699494.1 phosphopantothenate--cysteine ligase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 51712.42 Da        Isoelectric Point: 4.9706

>NTDB_id=1043496 ACD269_RS05820 WP_000886210.1 1132903..1134252(-) (micB) [Streptococcus pneumoniae strain FC2]
MLDLLKQTIFTRDFIFILILLGFILVVTLLLLENRRDNIQLKQINQKVKDLIAGDYSKVLDMQGGSEITNITNNLNDLSE
VIRLTQENLEQESKRLNSILFYMTDGVLATNRRGQIIMINDTAKKQLGLVKEDVLNRSILELLKIEENYELRDLITQSPE
LLLDSQDINGEYLNLRVRFALIRRESGFISGLVAVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALC
ETVAPDFIKVSLDETNRMMRMVTDLLHLSRIDNATSHLDVELINFTAFITFILNRFDKMKGQEKEKKYELVRDYPINSIW
MEIDTDKMTQVVDNILNNAIKYSPDGGKITVRMKTTEDQMILSISDHGLGIPKQDLPRIFDRFYRVDRARSRAQGGTGLG
LSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVKEEVWEDEVED

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=1043496 ACD269_RS05820 WP_000886210.1 1132903..1134252(-) (micB) [Streptococcus pneumoniae strain FC2]
ATGCTTGATTTACTGAAACAAACCATTTTTACCAGAGATTTTATCTTTATCCTGATTTTGTTAGGTTTCATCCTTGTTGT
GACCCTCTTATTACTGGAAAATAGACGTGATAATATTCAGTTGAAGCAAATCAATCAAAAGGTTAAAGATTTGATTGCAG
GAGATTATTCCAAGGTTCTTGATATGCAAGGTGGGTCTGAAATCACCAATATTACCAATAATTTGAATGACTTGTCGGAG
GTTATTCGTCTCACTCAGGAAAATCTAGAACAAGAGAGTAAGAGGCTAAATAGTATTCTGTTTTATATGACAGATGGGGT
TCTTGCGACCAACCGTCGGGGTCAGATTATCATGATTAACGATACAGCCAAGAAGCAACTGGGGTTGGTTAAGGAAGATG
TTCTGAATAGAAGCATTTTGGAATTGCTCAAGATAGAAGAAAACTATGAATTGCGTGATTTGATTACCCAAAGTCCAGAA
TTGTTGCTAGATTCCCAAGATATCAATGGCGAATATTTGAACCTTCGAGTTCGCTTTGCCTTGATACGTCGAGAGTCTGG
CTTTATTTCAGGTTTGGTGGCTGTTTTGCATGATACGACGGAGCAGGAGAAGGAAGAACGCGAACGAAGACTCTTTGTTT
CCAATGTTAGCCATGAGTTACGGACTCCTCTGACTAGCGTAAAATCCTATCTTGAAGCCTTGGATGAGGGGGCTTTGTGT
GAAACTGTAGCACCAGACTTTATCAAGGTTTCTCTTGATGAGACCAACCGTATGATGCGCATGGTGACGGATCTCCTCCA
TCTTTCACGTATTGATAATGCTACCAGTCACCTAGATGTGGAACTGATTAACTTCACTGCTTTTATTACCTTTATCCTCA
ATCGTTTTGACAAGATGAAAGGACAGGAAAAGGAGAAAAAATATGAGTTGGTGAGAGATTATCCCATCAATTCTATCTGG
ATGGAAATTGATACAGATAAGATGACGCAGGTTGTCGACAATATTTTAAATAATGCTATTAAGTATTCGCCAGATGGGGG
TAAAATCACTGTCAGAATGAAGACAACTGAAGACCAGATGATTTTATCCATTTCTGACCACGGTTTGGGGATTCCTAAGC
AGGATTTACCACGTATCTTTGACCGTTTCTATCGTGTGGATCGTGCTAGAAGTCGTGCACAAGGTGGTACAGGTCTAGGA
CTGTCTATCGCTAAAGAAATTATCAAACAACATAAGGGCTTTATTTGGGCCAAGAGTGAATACGGCAAGGGTTCAACCTT
TACCATTGTGCTCCCTTATGATAAGGATGCAGTGAAAGAAGAAGTATGGGAGGATGAAGTAGAAGACTAG

Domains

Predicted by InterproScan.

PAS fold (PAS)

(98-198)

His Kinase A (phospho-acceptor) domain (HisKA)

(209-273)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(324-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A064BZM9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micB Streptococcus pneumoniae Cp1015

99.777

100

0.998
  vicK Streptococcus mutans UA159

69.9

89.532

0.626

Multiple sequence alignment