Detailed information NTG1043497

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: ACD269_RS05825
• Genome accession: NZ_CP168260
• Coordinates: 1134245..1134949 (-)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae strain FC2
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1129245..1139949

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACD269_RS05795 (ACD269_05795)	-	1129437..1130423 (+)	987	WP_000204725.1	L-lactate dehydrogenase	-
ACD269_RS05800 (ACD269_05800)	-	1130683..1131456 (-)	774	WP_000731135.1	potassium channel family protein	-
ACD269_RS05805 (ACD269_05805)	-	1131503..1131757 (-)	255	WP_001809704.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ACD269_RS05810 (ACD269_05810)	relB	1131759..1132001 (-)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
ACD269_RS05815 (ACD269_05815)	vicX	1132092..1132901 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
ACD269_RS05820 (ACD269_05820)	micB	1132903..1134252 (-)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
ACD269_RS05825 (ACD269_05825)	micA	1134245..1134949 (-)	705	WP_000722076.1	response regulator YycF	Regulator
ACD269_RS05830 (ACD269_05830)	mutY	1135004..1136179 (-)	1176	WP_050238751.1	A/G-specific adenine glycosylase	-
ACD269_RS05835 (ACD269_05835)	-	1136276..1136401 (+)	126	WP_001818232.1	hypothetical protein	-
ACD269_RS05840 (ACD269_05840)	-	1136507..1138177 (-)	1671	WP_000845290.1	formate--tetrahydrofolate ligase	-
ACD269_RS05845 (ACD269_05845)	coaB	1138407..1139096 (+)	690	WP_000699494.1	phosphopantothenate--cysteine ligase	-
ACD269_RS05850 (ACD269_05850)	coaC	1139108..1139659 (+)	552	WP_001284128.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=1043497 ACD269_RS05825 WP_000722076.1 1134245..1134949(-) (micA) [Streptococcus pneumoniae strain FC2]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=1043497 ACD269_RS05825 WP_000722076.1 1134245..1134949(-) (micA) [Streptococcus pneumoniae strain FC2]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTAGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGCACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38