Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEC/celB   Type   Machinery gene
Locus tag   ACD269_RS04460 Genome accession   NZ_CP168260
Coordinates   864103..866343 (+) Length   746 a.a.
NCBI ID   WP_000942389.1    Uniprot ID   C1C6T2
Organism   Streptococcus pneumoniae strain FC2     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 859103..871343
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACD269_RS04430 (ACD269_04430) - 859253..860221 (+) 969 WP_000658183.1 PhoH family protein -
  ACD269_RS04435 (ACD269_04435) - 860414..860914 (+) 501 WP_000566988.1 GNAT family N-acetyltransferase -
  ACD269_RS04440 (ACD269_04440) - 860917..861243 (+) 327 Protein_875 TfoX/Sxy family protein -
  ACD269_RS04445 (ACD269_04445) ald 861544..862655 (-) 1112 Protein_876 alanine dehydrogenase -
  ACD269_RS04450 (ACD269_04450) - 862832..863401 (+) 570 WP_000443771.1 GNAT family N-acetyltransferase -
  ACD269_RS04455 (ACD269_04455) comEA/celA/cilE 863469..864119 (+) 651 WP_000387328.1 ComEA family DNA-binding protein Machinery gene
  ACD269_RS04460 (ACD269_04460) comEC/celB 864103..866343 (+) 2241 WP_000942389.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  ACD269_RS04465 (ACD269_04465) - 866485..866709 (+) 225 WP_015898758.1 hypothetical protein -
  ACD269_RS04470 (ACD269_04470) - 866741..867328 (+) 588 WP_000933540.1 ATP-binding cassette domain-containing protein -
  ACD269_RS04475 (ACD269_04475) - 867332..868516 (+) 1185 WP_000655947.1 ABC transporter permease -
  ACD269_RS04480 (ACD269_04480) infC 868818..869348 (+) 531 WP_000848180.1 translation initiation factor IF-3 -
  ACD269_RS04485 (ACD269_04485) rpmI 869381..869581 (+) 201 WP_001125943.1 50S ribosomal protein L35 -
  ACD269_RS04490 (ACD269_04490) rplT 869633..869992 (+) 360 WP_000124836.1 50S ribosomal protein L20 -
  ACD269_RS04495 (ACD269_04495) - 870050..870430 (+) 381 WP_373380876.1 VOC family protein -

Sequence

Protein


Download         Length: 746 a.a.        Molecular weight: 84538.08 Da        Isoelectric Point: 9.5835

>NTDB_id=1043492 ACD269_RS04460 WP_000942389.1 864103..866343(+) (comEC/celB) [Streptococcus pneumoniae strain FC2]
MLQWIKNFSIPLIYLSFLLLWLYYAIFSASYLALLGFVFLLVCLFIQFPWKSAGKVLIICGIFGFWFVFQNWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKSNGRAFQVYYKLQSEEEKEAFQALTDLHEIGLEGKLSEPEGQRNFGGFNYQAY
LKTQGIYQTLNIKKIQSLQKIGSWDIGENLSSLRRKAVVWIKTHFPDPMRNYMTGLLLGHLDTDFEEMSELYSSLGIIHL
FALSGMQVGFFMNGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLTGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFIV
MPNFFLTAGGVLSCAYAFILTMTSKEGKGLKAVASESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLTFLPLLSI
LFVLSFLYPVIQLNFIFEWLEGIIRLVSQVTSRPLVFGQPNAWLLILLLISLALVYDLRKNIKGLTVLSLLITGLFFLTK
YPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESYKKIEKWQEKMTTSNAQRTLIPYLKSRGVAKIDQLILTNTDK
EHVGDLSEVTKAFHVGEILVSKDSLKQKEFVAELQVTQTKVRSMTVGEYLPIFGSQLEVLSPREIGYGGHEDSLVLYGKL
LNNHFLFIGNLEEKGEKDLLKYYPDLKVNVLKASQHGNKKSSSPAFLEKLKPELTLISVGKSNRMKLPHQETLTRLEGIN
SKVYRTDQQGAIRFKGLDSWKIESVR

Nucleotide


Download         Length: 2241 bp        

>NTDB_id=1043492 ACD269_RS04460 WP_000942389.1 864103..866343(+) (comEC/celB) [Streptococcus pneumoniae strain FC2]
ATGTTACAGTGGATTAAGAATTTCTCTATTCCCCTAATTTACCTGAGTTTTCTATTACTTTGGCTTTATTACGCTATTTT
CTCAGCATCTTATCTTGCTTTGTTGGGCTTTGTTTTTCTGCTAGTCTGTCTCTTTATCCAATTTCCGTGGAAATCTGCTG
GTAAAGTTCTAATAATTTGCGGAATCTTTGGATTTTGGTTTGTTTTTCAAAATTGGCAACAGAGTCAAGCGAGTCAAAAT
CTGGCGGATTCTGTTGAAAGGGTACGGATTTTACCTGATACTATTAAGGTTAATGGTGATAGTCTATCCTTTCGTGGCAA
GTCTAACGGTCGTGCTTTCCAAGTCTATTATAAACTCCAGTCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACCGACC
TGCATGAGATAGGACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGCTTTAATTACCAAGCCTAT
CTGAAGACTCAGGGAATTTACCAGACTCTCAATATCAAAAAAATCCAGTCACTTCAAAAGATTGGCAGTTGGGATATAGG
AGAAAACTTGTCCAGTTTACGTCGAAAGGCTGTGGTTTGGATTAAGACGCACTTTCCAGACCCTATGCGCAATTACATGA
CAGGACTCTTGCTGGGACATCTGGACACCGACTTTGAGGAGATGAGTGAGCTTTATTCCAGTCTAGGAATTATCCACCTC
TTTGCCCTATCTGGCATGCAGGTAGGTTTTTTCATGAATGGATTTAAGAAACTTCTCTTGCGATTGGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATCTATGCGGGACTAACTGGATTTTCAGCATCGGTTATTCGCAGTC
TCTTGCAAAAGCTACTGGCTCAACATGGGGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATTGTC
ATGCCAAACTTTTTCTTGACAGCAGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCCTGACCATGACCAGCAAAGAAGG
GAAGGGGCTCAAGGCTGTTGCTAGTGAAAGTCTAGTCATCTCCTTGGGCATATTGCCCATTCTATCCTTCTATTTTGCGG
AATTTCAACCTTGGTCTATCCTTTTGACCTTTGTCTTTTCCTTTCTATTTGACTTGACCTTCTTACCGCTCTTGTCTATT
TTATTTGTCCTTTCCTTTCTCTATCCAGTCATTCAGCTGAACTTTATCTTTGAATGGTTGGAGGGCATTATTCGCTTGGT
CTCACAGGTGACAAGTAGGCCTCTAGTCTTTGGACAACCCAACGCATGGCTTTTAATCTTATTGTTAATTTCTTTGGCTT
TGGTCTATGATTTGAGGAAAAACATTAAAGGATTAACAGTATTGAGTTTATTGATTACAGGTCTCTTTTTCTTGACCAAG
TATCCACTGGAAAATGAAATCACCATGCTGGATGTGGGGCAAGGAGAAAGTATTTTCCTACGGGATGTAACTGGGAAAAC
CATTCTCATAGATGTAGGTGGTAAGGCAGAATCTTATAAGAAAATCGAAAAATGGCAAGAAAAGATGACGACCAGCAATG
CCCAGCGAACCTTGATTCCCTATCTCAAAAGTCGAGGAGTAGCTAAGATTGACCAGCTAATTTTGACTAACACGGACAAG
GAGCATGTTGGAGATTTGTCAGAGGTGACCAAGGCTTTCCATGTAGGGGAGATTCTAGTATCAAAAGACAGTCTGAAACA
GAAGGAATTTGTGGCAGAACTACAGGTGACTCAAACAAAGGTGCGTAGTATGACAGTAGGGGAGTACTTGCCCATTTTCG
GAAGTCAGTTAGAAGTCCTATCTCCAAGGGAAATTGGATATGGAGGTCATGAAGATTCCCTGGTTCTTTATGGGAAACTC
TTGAATAATCACTTTCTCTTCATAGGAAATTTGGAGGAGAAAGGAGAGAAGGACTTGCTGAAGTACTATCCAGACTTGAA
AGTAAATGTTTTGAAAGCTAGCCAACATGGCAATAAAAAATCATCAAGTCCAGCCTTTCTAGAAAAACTCAAACCAGAGC
TTACTCTTATCTCAGTTGGAAAGAGCAATCGAATGAAACTCCCCCATCAGGAAACATTGACACGACTGGAAGGTATCAAT
AGCAAAGTTTACCGAACTGACCAGCAAGGAGCTATACGCTTTAAGGGGTTGGATAGTTGGAAAATCGAAAGTGTTCGATA
G

Domains

Predicted by InterproScan.

Metallo-beta-lactamase superfamily (Lactamase_B)

(492-632)

Competence protein (Competence)

(216-458)

Domain of unknown function (DUF4131) (DUF4131)

(30-177)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C1C6T2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEC/celB Streptococcus pneumoniae TIGR4

96.783

100

0.968
  comEC/celB Streptococcus pneumoniae Rx1

95.979

100

0.96
  comEC/celB Streptococcus pneumoniae D39

95.979

100

0.96
  comEC/celB Streptococcus pneumoniae R6

95.979

100

0.96
  comEC/celB Streptococcus mitis SK321

91.957

100

0.92
  comEC/celB Streptococcus mitis NCTC 12261

91.544

99.866

0.914
  comEC Lactococcus lactis subsp. cremoris KW2

44.399

99.33

0.441

Multiple sequence alignment