Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   ACB345_RS01580 Genome accession   NZ_CP167025
Coordinates   295071..295757 (+) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain Isolate     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 290071..300757
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACB345_RS01555 (ACB345_01555) ktrB 290213..291589 (-) 1377 WP_032459750.1 potassium uptake transporter channel subunit KtrB -
  ACB345_RS01560 (ACB345_01560) rsmG 291674..292387 (-) 714 WP_014407313.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  ACB345_RS01565 (ACB345_01565) - 292537..293094 (+) 558 WP_002985956.1 LemA family protein -
  ACB345_RS01570 (ACB345_01570) htpX 293141..294037 (+) 897 WP_002985953.1 zinc metalloprotease HtpX -
  ACB345_RS01575 (ACB345_01575) - 294271..294804 (+) 534 WP_031488560.1 DUF177 domain-containing protein -
  ACB345_RS01580 (ACB345_01580) covR 295071..295757 (+) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  ACB345_RS01585 (ACB345_01585) covS 295763..297265 (+) 1503 WP_002991036.1 two-component system sensor histidine kinase CovS -
  ACB345_RS01590 (ACB345_01590) nrdR 297480..297974 (+) 495 WP_031488561.1 transcriptional regulator NrdR -
  ACB345_RS01595 (ACB345_01595) - 297958..299133 (+) 1176 WP_031488562.1 replication initiation and membrane attachment family protein -
  ACB345_RS01600 (ACB345_01600) dnaI 299134..300036 (+) 903 WP_002991016.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=1038127 ACB345_RS01580 WP_002991052.1 295071..295757(+) (covR) [Streptococcus pyogenes strain Isolate]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=1038127 ACB345_RS01580 WP_002991052.1 295071..295757(+) (covR) [Streptococcus pyogenes strain Isolate]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
CGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment