Detailed information NTG1038052

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: ACB338_RS00335
• Genome accession: NZ_CP167024
• Coordinates: 53093..54004 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain Isolate
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48093..59004

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB338_RS00315 (ACB338_00315)	purE	48430..48921 (+)	492	WP_015055884.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
ACB338_RS00320 (ACB338_00320)	purK	48908..49981 (+)	1074	WP_015055885.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
ACB338_RS00325 (ACB338_00325)	-	50008..51651 (+)	1644	WP_010921779.1	AIPR family protein	-
ACB338_RS00330 (ACB338_00330)	purB	51669..52961 (+)	1293	WP_010921780.1	adenylosuccinate lyase	-
ACB338_RS00335 (ACB338_00335)	comR	53093..54004 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
ACB338_RS00340 (ACB338_00340)	comS	54088..54183 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
ACB338_RS00345 (ACB338_00345)	ruvB	54230..55228 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
ACB338_RS00350 (ACB338_00350)	-	55366..55803 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
ACB338_RS00355 (ACB338_00355)	-	55826..56227 (+)	402	WP_010921781.1	MORN repeat-containing protein	-
ACB338_RS00360 (ACB338_00360)	-	56224..57999 (+)	1776	WP_010921782.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=1038052 ACB338_RS00335 WP_002986681.1 53093..54004(+) (comR) [Streptococcus pyogenes strain Isolate]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=1038052 ACB338_RS00335 WP_002986681.1 53093..54004(+) (comR) [Streptococcus pyogenes strain Isolate]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462