Detailed information NTG1037121

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: ACB360_RS00270
• Genome accession: NZ_CP167006
• Coordinates: 46844..47755 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain Isolate 26
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 41844..52755

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB360_RS00250 (ACB360_00250)	purE	42138..42629 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
ACB360_RS00255 (ACB360_00255)	purK	42616..43689 (+)	1074	WP_346393477.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
ACB360_RS00260 (ACB360_00260)	-	43710..45050 (+)	1341	WP_002987721.1	hypothetical protein	-
ACB360_RS00265 (ACB360_00265)	purB	45419..46711 (+)	1293	WP_002987723.1	adenylosuccinate lyase	-
ACB360_RS00270 (ACB360_00270)	comR	46844..47755 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
ACB360_RS00275 (ACB360_00275)	comS	47839..47934 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
ACB360_RS00280 (ACB360_00280)	ruvB	47981..48979 (+)	999	WP_002987726.1	Holliday junction branch migration DNA helicase RuvB	-
ACB360_RS00285 (ACB360_00285)	-	49117..49554 (+)	438	WP_002987727.1	low molecular weight protein-tyrosine-phosphatase	-
ACB360_RS00290 (ACB360_00290)	-	49578..49979 (+)	402	WP_002987730.1	MORN repeat-containing protein	-
ACB360_RS00295 (ACB360_00295)	-	49976..51751 (+)	1776	WP_002987732.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=1037121 ACB360_RS00270 WP_002986681.1 46844..47755(+) (comR) [Streptococcus pyogenes strain Isolate 26]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=1037121 ACB360_RS00270 WP_002986681.1 46844..47755(+) (comR) [Streptococcus pyogenes strain Isolate 26]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAGATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462