Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   ACB354_RS08475 Genome accession   NZ_CP167004
Coordinates   1607676..1608362 (-) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain Isolate 28     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1602676..1613362
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACB354_RS08455 (ACB354_08460) dnaI 1603397..1604299 (-) 903 WP_002991016.1 primosomal protein DnaI -
  ACB354_RS08460 (ACB354_08465) - 1604300..1605475 (-) 1176 WP_011184191.1 replication initiation and membrane attachment family protein -
  ACB354_RS08465 (ACB354_08470) nrdR 1605459..1605953 (-) 495 WP_159328629.1 transcriptional regulator NrdR -
  ACB354_RS08470 (ACB354_08475) covS 1606168..1607670 (-) 1503 WP_011184189.1 two-component system sensor histidine kinase CovS -
  ACB354_RS08475 (ACB354_08480) covR 1607676..1608362 (-) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  ACB354_RS08480 (ACB354_08485) - 1608629..1609162 (-) 534 WP_011054200.1 DUF177 domain-containing protein -
  ACB354_RS08485 (ACB354_08490) htpX 1609396..1610292 (-) 897 WP_002985953.1 zinc metalloprotease HtpX -
  ACB354_RS08490 (ACB354_08495) - 1610339..1610896 (-) 558 WP_002985956.1 LemA family protein -
  ACB354_RS08495 (ACB354_08500) rsmG 1611046..1611759 (+) 714 WP_011184187.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  ACB354_RS08500 (ACB354_08505) ktrB 1611844..1613220 (+) 1377 WP_023605004.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=1037057 ACB354_RS08475 WP_002991052.1 1607676..1608362(-) (covR) [Streptococcus pyogenes strain Isolate 28]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=1037057 ACB354_RS08475 WP_002991052.1 1607676..1608362(-) (covR) [Streptococcus pyogenes strain Isolate 28]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGCGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGTATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATGAATCGCGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGCTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment