Detailed information NTG1035869

Bioinformatically predicted

Overview

• Name: braR
• Type: Regulator
• Locus tag: MMH06_RS06015
• Genome accession: NZ_OV904788
• Coordinates: 1133708..1134385 (+)
• Length: 225 a.a.
• NCBI ID: WP_000548959.1
• Uniprot ID: Q9S1K2
• Organism: Streptococcus pneumoniae strain RMV7 isolate RMV7domi
• Function: promote expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1128708..1139385

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MMH06_RS05975	-	1128813..1128926 (-)	114	Protein_1138	glutamine ABC transporter permease	-
MMH06_RS05985 (IONPJBJN_01173)	-	1129057..1129703 (-)	647	Protein_1139	nicotinamide mononucleotide transporter	-
MMH06_RS11005	-	1129729..1129920 (-)	192	WP_001816503.1	hypothetical protein	-
MMH06_RS05990 (IONPJBJN_01174)	-	1129901..1130551 (-)	651	WP_000188505.1	metal-dependent transcriptional regulator	-
MMH06_RS05995 (IONPJBJN_01175)	-	1130663..1131505 (+)	843	WP_000160938.1	metallophosphoesterase family protein	-
MMH06_RS06000 (IONPJBJN_01176)	-	1131581..1132018 (+)	438	WP_001166785.1	Rrf2 family transcriptional regulator	-
MMH06_RS06005 (IONPJBJN_01177)	-	1132086..1132388 (+)	303	WP_000281609.1	hypothetical protein	-
MMH06_RS06010 (IONPJBJN_01178)	-	1132479..1133552 (-)	1074	WP_001273823.1	DUF2974 domain-containing protein	-
MMH06_RS06015 (IONPJBJN_01179)	braR	1133708..1134385 (+)	678	WP_000548959.1	response regulator transcription factor	Regulator
MMH06_RS06020 (IONPJBJN_01180)	-	1134378..1135352 (+)	975	WP_000887953.1	HAMP domain-containing histidine kinase	-
MMH06_RS06025 (IONPJBJN_01181)	thrS	1135401..1137344 (-)	1944	WP_000608349.1	threonine--tRNA ligase	-
MMH06_RS06030	-	1137402..1137578 (-)	177	WP_000166031.1	MazG-like protein	-
MMH06_RS06035 (IONPJBJN_01182)	-	1137585..1137725 (-)	141	WP_000422775.1	MazG-like protein	-
MMH06_RS06040 (IONPJBJN_01183)	-	1138155..1138355 (-)	201	WP_001814296.1	hypothetical protein	-
MMH06_RS06045 (IONPJBJN_01184)	-	1138593..1139222 (+)	630	WP_000762091.1	NAD(P)-dependent oxidoreductase	-

Sequence

Protein

• Length: 225 a.a.
• Molecular weight: 25964.16 Da
• Isoelectric Point: 5.1362

>NTDB_id=1035869 MMH06_RS06015 WP_000548959.1 1133708..1134385(+) (braR) [Streptococcus pneumoniae strain RMV7 isolate RMV7domi]
MHKILLIEDDQVIRQQIGKMLSEWGFEVVLVEDFMEVLSLFVQSEPHLVLMDIGLPLFNGYHWCQEIRKISKVPIMFLSS
RDQAMDIVMAINMGADDFVTKPFDQQVLLAKVQGLLRRSYEFGRDESLLEYAGVILNTKSMDLHYQGQVLNLTKNEFQIL
RVLFEHAGNIVARDDLMRELWNSDFFIDDNTLSVNVARLRKKLEEQGLVGFIETKKGIGYGLKHA

Nucleotide

• Length: 678 bp

>NTDB_id=1035869 MMH06_RS06015 WP_000548959.1 1133708..1134385(+) (braR) [Streptococcus pneumoniae strain RMV7 isolate RMV7domi]
ATGCACAAGATTTTATTAATAGAAGATGATCAGGTCATTCGTCAACAGATTGGGAAAATGCTCTCTGAATGGGGATTTGA
AGTGGTCCTGGTAGAAGACTTTATGGAAGTTTTGAGTCTATTTGTTCAGTCGGAACCTCATCTGGTCCTCATGGATATTG
GTTTGCCCTTGTTTAATGGTTATCACTGGTGTCAGGAAATCCGCAAGATTTCCAAGGTACCTATCATGTTTCTTTCTTCG
AGAGACCAGGCTATGGATATTGTCATGGCAATCAATATGGGGGCGGATGACTTTGTGACCAAGCCTTTTGACCAGCAGGT
TCTTTTAGCTAAGGTTCAGGGCTTGTTGCGTCGTTCCTATGAGTTTGGGCGTGATGAGAGTTTGCTGGAATATGCTGGTG
TTATCCTCAATACCAAATCCATGGATTTACATTATCAAGGGCAAGTCTTGAATTTGACCAAGAATGAATTCCAGATTTTA
CGCGTGTTATTTGAGCATGCAGGCAACATCGTAGCACGTGACGACCTGATGCGGGAACTTTGGAACAGTGACTTTTTCAT
TGATGATAATACCCTCTCTGTCAATGTGGCTCGTTTGCGTAAAAAGTTGGAGGAGCAGGGATTGGTAGGATTTATCGAGA
CCAAGAAAGGAATAGGGTACGGATTGAAGCATGCTTGA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (147-221)

3D structure

• AlphaFold DB: Q9S1K2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
braR	Staphylococcus aureus N315	48.624	96.889	0.471
vicR	Streptococcus mutans UA159	35.319	100	0.369