Detailed information NTG1019190

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: DQM50_RS04240
• Genome accession: NZ_LS483347
• Coordinates: 784091..786334 (+)
• Length: 747 a.a.
• NCBI ID: WP_085613979.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain NCTC8324
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 779091..791334

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM50_RS04215 (NCTC8324_00851)	-	779322..781322 (+)	2001	WP_085613978.1	potassium transporter Kup	-
DQM50_RS04220 (NCTC8324_00852)	-	781346..781624 (-)	279	WP_002989164.1	GIY-YIG nuclease family protein	-
DQM50_RS04225 (NCTC8324_00853)	-	781614..782390 (-)	777	WP_111688599.1	tRNA1(Val) (adenine(37)-N6)-methyltransferase	-
DQM50_RS04230 (NCTC8324_00854)	-	782508..783248 (+)	741	WP_021299345.1	lysophospholipid acyltransferase family protein	-
DQM50_RS04235 (NCTC8324_00855)	comEA/celA/cilE	783448..784110 (+)	663	WP_002995626.1	ComEA family DNA-binding protein	Machinery gene
DQM50_RS04240 (NCTC8324_00856)	comEC/celB	784091..786334 (+)	2244	WP_085613979.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
DQM50_RS04245 (NCTC8324_00857)	holA	786405..787445 (+)	1041	WP_011888795.1	DNA polymerase III subunit delta	-
DQM50_RS04250 (NCTC8324_00858)	sodA	787542..788147 (+)	606	WP_023078860.1	superoxide dismutase SodA	-
DQM50_RS04255 (NCTC8324_00859)	-	788314..788496 (+)	183	WP_023078840.1	hypothetical protein	-
DQM50_RS04265 (NCTC8324_00862)	-	788495..789347 (+)	853	Protein_771	serine hydrolase	-
DQM50_RS04270 (NCTC8324_00863)	-	789461..790681 (-)	1221	WP_085613980.1	DUF3114 domain-containing protein	-

Sequence

Protein

• Length: 747 a.a.
• Molecular weight: 85512.40 Da
• Isoelectric Point: 9.6062

>NTDB_id=1019190 DQM50_RS04240 WP_085613979.1 784091..786334(+) (comEC/celB) [Streptococcus pyogenes strain NCTC8324]
MTFSWTKLVPLSKIQFAFLILVLFYQIHSPSWLTFLLSLSLICLLVKRLSKKEFLGVFAILSFCALFLLYQKQQLVQKLE
IQPVQITSVALVPDSIRINGDQLAVLGRHGKHSYQLFYRLKSQAEVQLFKKEHRWLVMHAKVTLEKAEEVRNFKGFNYQT
FLAYQGIYRIGKVEQIEQLEVISPESICDYLSSLRRRAIVHCQQHFPRPMSHYLTGLLFGYLDKSFGEMTDYYSQLGIIH
LFVLSGMQVGFFLTCFRRVLLLLAVPLEWIKWIELPFACFYAALTGYSISVIRSLVQSQLRHLGIKGLDNLACTFLLVFL
WDAHFLMTVGGVLTFSYAFLLTVVTVEELSGAKRQLVQVLTISLGILPFLLFYFSSFNPMSMVLTGLLSYLFDLFILPLL
CLVFCLSPLVTVSICNHLFILLEKVIQFLGNTFNSSLVFGSPTSWHLLILVISFAIFYDYRQVRQRVITCGLVIALTLLS
IKYPLTNEVTFIDIGQGDSILVREWTGKNLLIDVGGRPFFSSKEHWRRGHHVANAQKTLIPYLKSRGIHTIDQLLVTHAD
TDHMGDIEVVAKAIRIKEILTSQGSLSDPSFVRRLRRLKCHVRVLAAGDQLPIMGSVLQVLYPWQLGDGKNNDSLVLYGR
LLNRTFLFTGDLEKEGENEIIKRYPQLRVDYLKAGHHGSNTSSSAAFLDHIQPKVAFISAGKNNRYQHPNRETLARLEDR
QITYYRTDTQGAIRLTGWTSWHLETVR

Nucleotide

• Length: 2244 bp

>NTDB_id=1019190 DQM50_RS04240 WP_085613979.1 784091..786334(+) (comEC/celB) [Streptococcus pyogenes strain NCTC8324]
ATGACATTTTCTTGGACTAAGCTAGTGCCCCTGTCAAAGATTCAATTTGCTTTTTTAATCTTGGTTCTCTTTTATCAAAT
CCATAGCCCTAGCTGGTTAACGTTTCTCCTTAGCCTTAGTTTGATTTGCTTACTTGTCAAGCGTTTGTCTAAAAAAGAAT
TTCTCGGTGTCTTTGCCATCCTTAGTTTCTGTGCTTTGTTTTTGCTGTATCAGAAACAGCAGTTGGTTCAAAAACTGGAA
ATTCAGCCAGTACAAATAACCTCTGTAGCATTAGTTCCTGATAGTATTCGGATTAATGGTGATCAATTAGCTGTTCTTGG
ACGTCATGGGAAACATTCTTATCAGTTATTTTACCGTTTGAAAAGCCAAGCAGAAGTCCAATTGTTCAAGAAAGAGCACC
GTTGGTTAGTGATGCACGCAAAAGTGACATTGGAAAAAGCTGAGGAAGTTCGAAATTTTAAAGGCTTTAATTATCAGACT
TTTTTGGCTTATCAAGGAATTTACAGGATAGGGAAGGTAGAGCAAATAGAACAGCTTGAAGTGATTTCACCCGAGTCAAT
ATGTGACTATTTGTCCTCTTTAAGACGACGAGCCATTGTTCATTGCCAGCAGCATTTTCCAAGACCTATGTCTCACTACC
TGACGGGCCTCCTTTTTGGTTATTTAGATAAGTCGTTTGGTGAGATGACAGATTATTATAGTCAGTTGGGTATCATTCAT
CTCTTTGTTTTATCAGGGATGCAGGTTGGCTTCTTTCTTACTTGTTTTAGAAGGGTGTTGCTATTACTCGCAGTTCCTTT
GGAATGGATAAAATGGATAGAGCTTCCTTTTGCTTGCTTTTATGCCGCGTTGACAGGTTATAGTATTTCTGTTATTCGAA
GCCTCGTGCAGTCGCAGTTGCGTCATTTAGGAATAAAAGGATTAGACAATCTGGCTTGTACTTTTTTACTTGTCTTTTTA
TGGGATGCTCATTTCTTAATGACTGTTGGTGGCGTATTAACGTTTAGCTATGCTTTTTTGTTAACAGTGGTTACTGTTGA
AGAATTATCAGGAGCTAAAAGACAGTTGGTACAAGTCTTGACCATTTCCCTAGGAATATTACCATTTTTGCTCTTTTATT
TTTCCAGTTTTAACCCCATGTCAATGGTCTTAACAGGGCTCTTGTCTTATCTCTTTGACCTTTTTATTTTGCCCCTTCTT
TGTCTGGTTTTTTGTCTATCCCCTTTGGTGACTGTCTCAATATGCAACCATCTTTTTATTTTATTAGAAAAAGTCATTCA
ATTTCTCGGAAATACTTTCAATAGTTCCCTTGTTTTTGGAAGCCCGACCAGTTGGCACTTGCTTATCTTGGTGATTAGCT
TCGCTATTTTTTATGATTATCGGCAGGTGCGACAACGAGTTATCACTTGCGGTTTGGTTATAGCGTTGACGCTTTTGTCT
ATCAAATATCCTTTGACCAATGAAGTGACCTTTATCGACATTGGCCAGGGAGATAGTATTTTGGTGAGGGAGTGGACAGG
GAAAAATCTCTTAATAGATGTAGGTGGGCGCCCTTTCTTTTCTTCAAAAGAGCACTGGCGACGAGGACATCACGTAGCTA
ATGCTCAGAAAACCTTAATTCCTTACTTAAAAAGTAGAGGTATTCACACAATTGACCAACTATTAGTAACTCACGCAGAT
ACTGATCATATGGGGGATATCGAAGTGGTTGCCAAAGCTATTCGGATAAAGGAGATTTTGACTAGTCAAGGCAGTTTAAG
CGATCCAAGCTTTGTTAGGCGGCTAAGGCGTTTAAAATGTCACGTTAGGGTTTTAGCAGCTGGAGACCAGTTGCCTATTA
TGGGAAGTGTCTTACAGGTACTCTACCCTTGGCAGTTAGGGGACGGGAAAAATAACGATTCTTTGGTACTTTATGGCAGG
CTCTTAAATCGAACTTTTCTTTTCACAGGTGACTTGGAAAAAGAGGGGGAAAACGAGATCATAAAACGTTATCCTCAACT
AAGAGTAGATTATTTAAAAGCAGGTCACCATGGATCAAATACCTCTTCTAGTGCAGCTTTTTTAGACCATATTCAACCTA
AAGTGGCCTTTATTTCTGCTGGAAAAAATAACCGTTATCAGCATCCTAACAGAGAAACCTTAGCCCGTTTGGAAGACAGA
CAAATTACTTATTACCGAACGGATACGCAAGGAGCTATTCGTTTGACTGGTTGGACAAGCTGGCATCTTGAAACGGTCCG
TTAG

Domains

Predicted by InterProScan.

• Metallo-beta-lactamase superfamily (Lactamase_B) (495-701)

• Competence protein (Competence) (217-462)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis SK321	46.051	100	0.461
comEC/celB	Streptococcus mitis NCTC 12261	45.845	99.866	0.458
comEC/celB	Streptococcus pneumoniae TIGR4	44.846	100	0.448
comEC/celB	Streptococcus pneumoniae Rx1	44.786	100	0.448
comEC/celB	Streptococcus pneumoniae D39	44.786	100	0.448
comEC/celB	Streptococcus pneumoniae R6	44.786	100	0.448
comEC	Lactococcus lactis subsp. cremoris KW2	40.537	99.732	0.404