Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   DQM73_RS00630 Genome accession   NZ_LS483346
Coordinates   111460..113406 (+) Length   648 a.a.
NCBI ID   WP_032908260.1    Uniprot ID   -
Organism   Streptococcus sanguinis strain NCTC11085     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 106460..118406
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQM73_RS00610 (NCTC11085_00117) argR 107250..107687 (+) 438 WP_002902018.1 arginine repressor -
  DQM73_RS00615 (NCTC11085_00118) hexA 107766..110315 (+) 2550 WP_002926375.1 DNA mismatch repair protein MutS Machinery gene
  DQM73_RS00620 (NCTC11085_00119) - 110364..110834 (-) 471 WP_002926374.1 DUF3021 family protein -
  DQM73_RS00625 (NCTC11085_00120) brsR 110831..111271 (-) 441 WP_002926373.1 LytTR family DNA-binding domain-containing protein Regulator
  DQM73_RS00630 (NCTC11085_00121) hexB 111460..113406 (+) 1947 WP_032908260.1 DNA mismatch repair endonuclease MutL Machinery gene
  DQM73_RS00635 (NCTC11085_00122) - 113442..113963 (-) 522 WP_002926371.1 RDD family protein -
  DQM73_RS00640 (NCTC11085_00123) - 113947..114453 (-) 507 WP_002908492.1 helix-turn-helix domain-containing protein -
  DQM73_RS00645 (NCTC11085_00124) ruvA 114623..115213 (+) 591 WP_032908259.1 Holliday junction branch migration protein RuvA Machinery gene
  DQM73_RS00650 (NCTC11085_00125) - 115224..115796 (+) 573 WP_002908494.1 DNA-3-methyladenine glycosylase I -
  DQM73_RS00655 (NCTC11085_00126) - 115806..116654 (-) 849 WP_002926370.1 helix-turn-helix domain-containing protein -
  DQM73_RS00665 (NCTC11085_00128) - 117253..117531 (+) 279 WP_223310420.1 bacteriocin immunity protein -

Sequence

Protein


Download         Length: 648 a.a.        Molecular weight: 73338.32 Da        Isoelectric Point: 4.9433

>NTDB_id=1019031 DQM73_RS00630 WP_032908260.1 111460..113406(+) (hexB) [Streptococcus sanguinis strain NCTC11085]
MSKIIELPEILANQIAAGEVIERPSSVVKELVENSIDAGASQITIEIEEAGLKSIQVTDNGEGIDHEDVPLALRRHATSK
IKKQADLFRIRTLGFRGEAIPSIASVSRFTIETATEAGQHGTLLVAQGGEIEEHEPTSSPVGTKIKIEDLFFNTPARLKY
MKSQQAELSHIVDVINRLSLAHPEVAFTLISDGREMTRTAGSGDLRQAIAGIYGLATAKKMVEISASDLDFEVSGYVSLP
ELTRANRNYITILINGRYIKNFLLNRAILDGYGSKLMVGRFPLAVINIQIDPYLADVNVHPTKQEVRISKERELMALISQ
AIATSLKEQDLIPDALENLAKSTVKRATKPEQTSLPLKENRLYYDKEQDDFFLKPHVSEQQLSFEESAETVHEAADEKSE
PPQPTSVKFAERKPASYDQLDHPELDQASLERAVDKLEQEEKSSFPELEYFGQMHGTYLFAQGKGGLYIIDQHAAQERVK
YEYYREKIGDVDNSQQQLLVPYIFEFPADDMLRIKQRMELLEDAGIFLEEYGANQFILREHPIWFKEEEIEAGIYEMCDM
LLLTKEVSIKKYRAELAIMMSCKRSIKANHSLDDYSARDLLFQLSQCDNPYNCPHGRPVLVNFTKSDMEKMFRRIQENHT
SLRELGKY

Nucleotide


Download         Length: 1947 bp        

>NTDB_id=1019031 DQM73_RS00630 WP_032908260.1 111460..113406(+) (hexB) [Streptococcus sanguinis strain NCTC11085]
ATGTCAAAAATTATCGAACTTCCAGAAATTCTAGCCAATCAGATTGCGGCCGGTGAAGTCATTGAGCGGCCTAGCAGCGT
GGTCAAGGAGCTAGTGGAAAATTCAATTGATGCGGGTGCAAGCCAGATTACCATCGAAATCGAGGAGGCCGGACTCAAGA
GCATTCAGGTAACGGATAATGGCGAAGGCATAGACCACGAAGATGTTCCTCTGGCCCTTCGACGCCATGCTACCAGTAAA
ATCAAGAAGCAGGCGGATCTCTTTCGGATTCGGACATTGGGTTTCCGTGGTGAGGCCATTCCTTCCATTGCTTCTGTCTC
GCGTTTTACTATTGAGACAGCGACGGAAGCCGGCCAGCACGGGACTCTGCTGGTTGCCCAGGGTGGCGAGATCGAAGAGC
ATGAGCCTACCAGCAGTCCGGTAGGAACGAAAATCAAGATAGAAGATCTCTTCTTTAATACTCCAGCCCGGCTCAAGTAT
ATGAAGAGCCAGCAGGCAGAGCTTTCCCATATCGTTGATGTGATTAATCGGCTTAGTCTGGCCCATCCGGAAGTGGCTTT
CACCCTTATCAGTGACGGCCGCGAAATGACACGGACTGCCGGCAGTGGCGATCTGCGTCAGGCTATTGCAGGCATCTATG
GTCTGGCAACAGCCAAGAAAATGGTGGAAATCTCTGCTTCAGATCTGGACTTTGAAGTGAGCGGCTATGTCAGCCTGCCT
GAGCTGACTCGTGCGAATCGGAATTATATTACGATTCTCATCAACGGCCGCTACATTAAGAATTTCCTGCTTAATCGTGC
TATTTTGGACGGCTACGGCAGCAAGCTGATGGTAGGCCGCTTTCCACTCGCAGTCATCAATATTCAGATTGACCCCTATC
TGGCTGATGTCAATGTCCATCCGACAAAGCAAGAGGTGCGGATTTCTAAAGAGCGGGAACTCATGGCCTTGATTTCGCAA
GCCATTGCGACCAGTCTCAAGGAACAGGATCTTATCCCGGATGCTTTGGAAAATCTAGCCAAATCAACTGTTAAGCGTGC
GACTAAACCCGAACAGACCAGTCTTCCGCTGAAAGAAAATCGCCTCTACTACGATAAGGAGCAGGATGACTTCTTCCTCA
AACCACATGTGTCAGAGCAGCAGCTATCCTTTGAAGAATCAGCGGAGACTGTTCATGAAGCAGCAGATGAAAAATCAGAA
CCGCCACAACCGACTTCGGTCAAATTCGCAGAGAGAAAGCCGGCCAGCTATGACCAACTAGACCATCCAGAGTTAGATCA
AGCCAGTTTGGAGCGGGCTGTGGATAAGTTGGAACAGGAAGAGAAATCAAGCTTCCCAGAGTTAGAATATTTCGGCCAGA
TGCATGGCACCTATCTATTTGCTCAGGGCAAGGGCGGTCTTTACATTATTGACCAGCATGCTGCTCAAGAGCGGGTCAAG
TATGAGTATTATCGGGAGAAGATTGGGGATGTGGACAATAGCCAGCAGCAGCTCTTGGTGCCTTATATCTTTGAATTTCC
AGCGGACGATATGCTGAGAATCAAGCAGCGGATGGAGCTGTTAGAAGACGCTGGCATCTTTTTAGAAGAGTACGGAGCCA
ATCAATTTATCCTCCGTGAACATCCCATTTGGTTCAAGGAAGAGGAGATTGAGGCCGGCATCTATGAGATGTGTGATATG
CTTCTCCTGACCAAGGAAGTTTCCATCAAGAAATATCGAGCAGAACTAGCCATTATGATGAGCTGCAAACGCTCTATCAA
GGCCAATCACAGTCTGGATGACTACTCTGCGCGTGACTTGCTCTTTCAGCTGTCCCAGTGTGACAATCCTTACAACTGCC
CACATGGCCGACCGGTCTTGGTCAACTTTACCAAGTCGGATATGGAAAAAATGTTCCGCCGCATTCAGGAAAATCATACT
AGCCTGCGGGAGTTAGGGAAATACTAA

Domains

Predicted by InterProScan.

MutL C terminal dimerisation domain (MutL_C)

(450-592)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-116)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

77.966

100

0.781