Detailed information NTG1019029

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: DQM73_RS00615
• Genome accession: NZ_LS483346
• Coordinates: 107766..110315 (+)
• Length: 849 a.a.
• NCBI ID: WP_002926375.1
• Uniprot ID: -
• Organism: Streptococcus sanguinis strain NCTC11085
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 102766..115315

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM73_RS12290	-	103963..104127 (+)	165	WP_002926390.1	hypothetical protein	-
DQM73_RS00595 (NCTC11085_00114)	-	104160..104678 (+)	519	WP_002926389.1	hypothetical protein	-
DQM73_RS00600 (NCTC11085_00115)	nrdI	104741..105229 (+)	489	WP_002926388.1	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	-
DQM73_RS00605 (NCTC11085_00116)	argS	105261..106949 (-)	1689	WP_002926387.1	arginine--tRNA ligase	-
DQM73_RS00610 (NCTC11085_00117)	argR	107250..107687 (+)	438	WP_002902018.1	arginine repressor	-
DQM73_RS00615 (NCTC11085_00118)	hexA	107766..110315 (+)	2550	WP_002926375.1	DNA mismatch repair protein MutS	Machinery gene
DQM73_RS00620 (NCTC11085_00119)	-	110364..110834 (-)	471	WP_002926374.1	DUF3021 family protein	-
DQM73_RS00625 (NCTC11085_00120)	brsR	110831..111271 (-)	441	WP_002926373.1	LytTR family DNA-binding domain-containing protein	Regulator
DQM73_RS00630 (NCTC11085_00121)	hexB	111460..113406 (+)	1947	WP_032908260.1	DNA mismatch repair endonuclease MutL	Machinery gene
DQM73_RS00635 (NCTC11085_00122)	-	113442..113963 (-)	522	WP_002926371.1	RDD family protein	-
DQM73_RS00640 (NCTC11085_00123)	-	113947..114453 (-)	507	WP_002908492.1	helix-turn-helix domain-containing protein	-
DQM73_RS00645 (NCTC11085_00124)	ruvA	114623..115213 (+)	591	WP_032908259.1	Holliday junction branch migration protein RuvA	Machinery gene

Sequence

Protein

• Length: 849 a.a.
• Molecular weight: 94821.27 Da
• Isoelectric Point: 4.9310

>NTDB_id=1019029 DQM73_RS00615 WP_002926375.1 107766..110315(+) (hexA) [Streptococcus sanguinis strain NCTC11085]
MAVEKLSPGMQQYLDIKKDYPDAFLLFRMGDFYELFYDDAVNAAQILEISLTSRNKNAENPIPMAGVPYHSAQQYIDVLV
ESGYKVAIAEQMEDPKEAKGVVKREVVQVITPGTVVDSSKPDSANNFLVALDYSDGLYGLAYMDLVTGEFQVTSLEDFAL
VCGEIRNLKAREVVLGYALPEAEEQVLAGQMNLLLSYVQTALDDVQLLGEELSPMERQAAGKLLEYVHRTQMRELSHLKK
AQHYEIKDFLQMDYATKASLDLTENARSGKKHGSLYWLMDETKTAMGGRMLRSWIQRPLIDEARISQRQNVVEVFLDHFF
ERSDLTESLKGVYDIERLASRVSFGKTNPKDLLQLAATLGNVPQIKAILQGIGSPHLARLIEGLDPIPELAGLISSAISP
DAPHIITEGNIIRTGFDETLDQYRLVLREGTGWIAELEVKERANSGISNLKIDYNKKDGYYFHVTNSQLAHVPSHFFRKA
TLKNSERFGTEELARIEGEMLEAREKSANLEYEIFMRIREEAGKYIQRLQALAQTLAAVDVLQSFAAVAEQLHLVRPVFT
AERRLQIEKGRHAVVEKVMGAQSYIPNSILLDQETDIQLITGPNMSGKSTYMRQLAIIVIMAQMGSYVPAQSASLPIFDA
IFTRIGAADDLVSGQSTFMVEMMEANRAIRQASERSLILFDELGRGTATYDGMALAQAIIEHIHHYTGAKTLFATHYHEL
TALEESLEHLENVHVATLEKDGQVTFLHKIEPGPADKSYGIHVAKIAGLPEKLLERADNILSHLESQDTGLDLELPAASR
PKQSQVAEQMSLFAEGTENPVLTELRDLDIYNMTPLEVMAAVAELKKKL

Nucleotide

• Length: 2550 bp

>NTDB_id=1019029 DQM73_RS00615 WP_002926375.1 107766..110315(+) (hexA) [Streptococcus sanguinis strain NCTC11085]
ATGGCAGTAGAAAAGTTATCGCCAGGCATGCAGCAGTATTTGGATATCAAAAAGGACTATCCAGATGCTTTCTTGCTCTT
TCGGATGGGGGATTTCTATGAGTTGTTTTATGATGATGCGGTCAATGCCGCCCAGATTTTAGAGATTTCTCTCACTAGCC
GAAATAAAAATGCAGAAAATCCCATTCCCATGGCCGGAGTTCCTTATCATTCGGCACAGCAGTATATTGATGTTTTGGTC
GAGTCAGGCTATAAGGTAGCGATTGCGGAGCAGATGGAAGATCCCAAGGAAGCCAAGGGAGTTGTTAAGCGGGAGGTTGT
TCAGGTTATCACTCCGGGGACGGTGGTGGACTCCAGTAAGCCGGACTCTGCTAATAACTTTCTGGTGGCTCTGGATTACT
CAGATGGCCTCTATGGTCTGGCTTATATGGATTTGGTGACCGGTGAGTTTCAGGTGACCAGTCTAGAGGACTTTGCCTTG
GTCTGCGGGGAAATTCGCAATTTGAAGGCTAGGGAAGTGGTGCTGGGCTATGCCTTGCCAGAAGCTGAGGAGCAGGTCTT
GGCTGGGCAGATGAACCTTTTACTGTCCTATGTACAGACGGCCTTGGACGATGTCCAGCTGCTAGGCGAGGAGTTGTCTC
CGATGGAACGTCAGGCAGCGGGGAAATTGCTTGAGTATGTGCACCGGACCCAGATGAGGGAGCTCAGCCATTTGAAGAAG
GCTCAGCATTATGAAATCAAGGACTTTCTGCAAATGGACTATGCCACCAAGGCAAGTCTGGATTTGACAGAAAATGCTCG
CTCGGGCAAGAAGCACGGCAGTCTTTATTGGCTGATGGACGAGACTAAGACGGCCATGGGCGGCCGCATGCTGCGCTCTT
GGATTCAGCGGCCGCTGATTGATGAAGCGCGAATTAGCCAGCGGCAGAATGTCGTCGAGGTTTTTCTGGATCATTTCTTT
GAGCGGAGTGATTTGACGGAGAGCCTCAAGGGAGTCTATGATATCGAGCGGTTGGCTAGTCGGGTGTCTTTTGGCAAGAC
CAATCCCAAGGATCTGCTGCAGTTGGCAGCAACATTGGGCAATGTGCCTCAGATTAAGGCTATCTTGCAAGGAATCGGTA
GCCCGCATCTAGCTCGTTTGATTGAGGGCTTGGATCCTATTCCAGAGTTGGCAGGCTTGATTAGCTCAGCTATTTCGCCG
GATGCACCCCATATCATCACCGAGGGCAATATCATTCGGACCGGTTTTGATGAAACCTTGGATCAGTATCGGCTTGTGCT
GAGGGAGGGGACTGGATGGATTGCGGAGCTGGAAGTCAAAGAACGTGCTAACAGCGGCATCAGCAATCTGAAGATTGATT
ACAACAAAAAAGATGGTTACTATTTCCATGTGACCAATTCTCAGCTGGCTCATGTGCCTAGTCATTTCTTCCGCAAGGCG
ACCCTGAAAAATTCTGAGCGTTTCGGAACGGAGGAGCTGGCCCGGATTGAGGGAGAGATGTTGGAGGCGCGTGAAAAATC
TGCTAATCTGGAATACGAGATTTTCATGCGGATTCGCGAGGAAGCTGGCAAATACATCCAGCGCTTGCAGGCCTTGGCGC
AAACTCTGGCAGCTGTAGATGTCCTGCAGAGCTTTGCTGCGGTAGCGGAGCAACTACATTTGGTGCGCCCCGTCTTTACT
GCAGAGCGCCGTCTGCAGATTGAAAAAGGACGGCATGCTGTTGTGGAAAAGGTCATGGGAGCCCAAAGCTACATTCCAAA
TAGTATTCTGCTGGACCAGGAAACGGACATCCAGCTGATTACCGGGCCTAATATGAGCGGGAAATCAACTTATATGCGCC
AGCTGGCTATCATCGTTATTATGGCACAGATGGGCTCTTATGTGCCCGCTCAGTCTGCCAGTCTGCCAATATTTGATGCG
ATTTTCACTCGCATCGGTGCGGCGGATGATCTGGTGTCCGGCCAGTCCACCTTTATGGTGGAGATGATGGAGGCCAATCG
GGCCATTCGGCAGGCCAGCGAGCGTTCGCTTATTCTCTTTGATGAGCTGGGCCGTGGGACGGCGACTTACGATGGGATGG
CGCTGGCTCAGGCTATTATTGAGCATATTCATCATTATACTGGAGCTAAGACCCTCTTTGCCACCCACTATCATGAGCTG
ACAGCCTTAGAGGAAAGTTTGGAGCATTTGGAAAATGTCCATGTGGCAACCTTGGAAAAGGACGGGCAGGTGACTTTCCT
GCATAAGATTGAGCCGGGTCCGGCTGACAAGTCCTACGGGATTCACGTGGCGAAAATTGCCGGTCTTCCTGAGAAATTAC
TGGAGCGGGCGGATAACATTTTGAGTCATTTGGAAAGTCAGGATACAGGATTAGACTTAGAGCTTCCTGCTGCATCCAGA
CCGAAGCAGTCGCAAGTGGCGGAGCAGATGTCTCTTTTTGCAGAAGGAACGGAAAATCCAGTCCTGACTGAACTACGAGA
CTTGGACATCTACAATATGACTCCCCTGGAAGTCATGGCAGCAGTGGCCGAGCTCAAGAAGAAGTTGTAA

Domains

Predicted by InterProScan.

• MutS domain II (MutS_II) (126-239)

• MutS domain V (MutS_V) (599-785)

• MutS domain I (MutS_I) (8-118)

• MutS domain III (MutS_III) (256-546)

• MutS family domain IV (MutS_IV) (415-505)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	77.739	100	0.777
mutS	Pseudomonas stutzeri strain ATCC 17587	38.856	100	0.392