Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   DQL59_RS00345 Genome accession   NZ_LS483326
Coordinates   55274..56185 (+) Length   303 a.a.
NCBI ID   WP_002986681.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NCTC12045     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 50274..61185
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL59_RS00330 (NCTC12045_00065) - 52117..53229 (+) 1113 WP_032464126.1 DUF262 domain-containing protein -
  DQL59_RS00335 (NCTC12045_00066) - 53233..53841 (+) 609 WP_032464127.1 hypothetical protein -
  DQL59_RS00340 (NCTC12045_00067) purB 53851..55143 (+) 1293 WP_032464128.1 adenylosuccinate lyase -
  DQL59_RS00345 (NCTC12045_00068) comR 55274..56185 (+) 912 WP_002986681.1 transcriptional regulator Rgg4/ComR Regulator
  DQL59_RS09190 (NCTC12045_00069) comS 56269..56364 (+) 96 WP_198462994.1 quorum-sensing system DWW-type pheromone Regulator
  DQL59_RS00350 (NCTC12045_00070) ruvB 56411..57409 (+) 999 WP_111680962.1 Holliday junction branch migration DNA helicase RuvB Machinery gene
  DQL59_RS00355 (NCTC12045_00071) - 57547..57984 (+) 438 WP_002994668.1 low molecular weight protein-tyrosine-phosphatase -
  DQL59_RS00360 (NCTC12045_00072) - 58007..58408 (+) 402 WP_002986671.1 MORN repeat-containing protein -
  DQL59_RS00365 (NCTC12045_00073) - 58405..60180 (+) 1776 WP_111680963.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 35757.27 Da        Isoelectric Point: 4.4858

>NTDB_id=1017353 DQL59_RS00345 WP_002986681.1 55274..56185(+) (comR) [Streptococcus pyogenes strain NCTC12045]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide


Download         Length: 912 bp        

>NTDB_id=1017353 DQL59_RS00345 WP_002986681.1 55274..56185(+) (comR) [Streptococcus pyogenes strain NCTC12045]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterProScan.

Helix-turn-helix (HTH_3)

(12-64)

ComR tetratricopeptide (ComR_TPR)

(73-296)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

100

100

1
  comR Streptococcus pyogenes MGAS315

58.472

99.34

0.581
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

51.37

96.37

0.495
  comR Streptococcus mutans UA159

46.358

99.67

0.462

Multiple sequence alignment