Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB   Type   Regulator
Locus tag   H1W95_RS08030 Genome accession   NZ_LR822030
Coordinates   1559313..1560680 (-) Length   455 a.a.
NCBI ID   WP_011681574.1    Uniprot ID   -
Organism   Streptococcus thermophilus isolate STH_CIRM_1046     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 1554313..1565680
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H1W95_RS10635 (STHERMO_1800) - 1554408..1554809 (-) 402 WP_024703992.1 hypothetical protein -
  H1W95_RS08000 (STHERMO_1805) - 1555814..1556044 (-) 231 WP_014608662.1 bacteriocin class II family protein -
  H1W95_RS08005 (STHERMO_1806) - 1556401..1556601 (-) 201 WP_011681569.1 hypothetical protein -
  H1W95_RS08010 (STHERMO_1807) - 1556620..1556796 (-) 177 WP_011681570.1 Blp family class II bacteriocin -
  H1W95_RS08015 (STHERMO_1808) - 1557048..1557785 (+) 738 WP_011681571.1 LytR/AlgR family response regulator transcription factor -
  H1W95_RS10330 comD/blpH 1558316..1559119 (+) 804 WP_223899638.1 ATP-binding protein Regulator
  H1W95_RS08025 (STHERMO_1810) - 1559137..1559298 (-) 162 WP_011681573.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  H1W95_RS08030 (STHERMO_1811) comB 1559313..1560680 (-) 1368 WP_011681574.1 bacteriocin secretion accessory protein Regulator
  H1W95_RS08035 (STHERMO_1812) comA/nlmT 1560696..1562849 (-) 2154 WP_157795756.1 peptide cleavage/export ABC transporter Regulator
  H1W95_RS08040 (STHERMO_1817) - 1563863..1565608 (-) 1746 WP_100262366.1 ABC transporter ATP-binding protein -

Sequence

Protein


Download         Length: 455 a.a.        Molecular weight: 50382.07 Da        Isoelectric Point: 4.7492

>NTDB_id=1010643 H1W95_RS08030 WP_011681574.1 1559313..1560680(-) (comB) [Streptococcus thermophilus isolate STH_CIRM_1046]
MNPQLFKSTEFYHRRYHNMSTVLITPLILLVIFLFLFAFFAKKEVTVTSRGSIEPTKVIAVIQSTSDNTIIDNQLVANKV
VKKGDTLVQYSETMEASQKEGLQKQLELLKRQESGLKTLQSSLTQGTNLFQEQEDEFGYQSTFNTYLSQAQDIDLGVAKT
NTEVNNQAAIASNTGSAIDNQISQLQTQVSEYEALSQAITNHETTLPEGNPHQATLNAYNSQYATTPDASVTDQYLSQVN
TNISSLNASIGNLEIQKAGTGTVVTYDNSDSTKKEALKNQFLQNAGQQLSSVETQINDTESKINQADVLLTNTLIQSPED
GILHLSQADKKATMAATGTELAQLYPDMTQTQEVAITYYVNSDYVPKLQKGQSVRLTLDKVGNHGTTIIGKLESIDNSAT
ETERGNVFRVTARASISEKEAQNLRYGLEGRVTSVIDQKTYFNYFKDKLLNLQDQ

Nucleotide


Download         Length: 1368 bp        

>NTDB_id=1010643 H1W95_RS08030 WP_011681574.1 1559313..1560680(-) (comB) [Streptococcus thermophilus isolate STH_CIRM_1046]
ATGAATCCACAGTTGTTTAAAAGCACAGAGTTTTACCATCGTCGCTACCACAATATGTCTACTGTTTTGATTACTCCCTT
GATTTTGTTAGTTATTTTCCTTTTTCTTTTCGCTTTTTTTGCTAAGAAGGAAGTTACAGTCACGTCTAGAGGAAGTATAG
AGCCAACCAAGGTTATCGCAGTAATCCAATCAACCAGTGACAATACCATCATAGATAATCAACTGGTTGCTAATAAGGTT
GTTAAAAAAGGGGACACCTTAGTTCAGTATTCAGAGACCATGGAGGCATCGCAAAAAGAGGGGCTTCAAAAGCAACTAGA
ACTTTTAAAAAGACAGGAATCAGGTTTGAAGACCTTGCAATCTAGCCTAACGCAGGGAACCAATCTTTTCCAAGAACAGG
AAGACGAGTTTGGTTATCAGAGTACTTTTAACACCTACCTAAGTCAGGCACAGGATATTGACTTGGGTGTGGCTAAAACA
AATACAGAGGTTAATAACCAAGCAGCAATTGCGAGTAATACCGGTTCTGCTATTGATAACCAGATTAGTCAATTGCAGAC
TCAGGTCTCAGAGTATGAGGCGCTCTCTCAAGCTATTACCAATCATGAAACGACTTTACCTGAAGGCAATCCTCATCAGG
CAACCTTAAATGCCTATAACAGTCAGTATGCTACGACACCGGATGCCAGTGTAACAGACCAATACCTATCTCAAGTTAAT
ACCAATATTTCGAGCTTGAATGCTTCCATAGGTAATCTAGAAATCCAAAAGGCTGGGACAGGCACAGTTGTAACTTATGA
CAATAGTGATAGCACTAAAAAAGAAGCTCTAAAAAATCAATTCTTGCAAAATGCAGGACAGCAATTGAGCTCAGTGGAAA
CACAAATTAACGATACCGAGAGTAAAATCAATCAGGCAGATGTCCTTCTGACTAATACCCTCATCCAGTCACCAGAAGAT
GGAATCTTACACTTGAGTCAAGCTGATAAAAAAGCAACCATGGCTGCGACAGGAACTGAGTTGGCCCAGCTTTATCCCGA
TATGACTCAAACCCAGGAAGTTGCCATTACTTATTATGTGAATTCGGATTATGTGCCAAAACTGCAAAAAGGCCAGTCAG
TTCGACTGACCTTGGATAAGGTTGGTAATCACGGTACCACAATTATTGGAAAACTTGAGAGTATTGATAATTCTGCCACG
GAAACAGAAAGGGGGAATGTGTTTAGAGTAACTGCTAGGGCAAGTATTTCAGAAAAAGAAGCCCAAAATCTACGTTACGG
TCTAGAAGGTCGTGTGACAAGCGTTATTGACCAAAAGACCTACTTCAATTACTTTAAAGACAAGTTACTAAACTTGCAAG
ACCAATAG

Domains

Predicted by InterProScan.

HlyD family secretion protein ()

(315-427)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB Streptococcus pneumoniae Rx1

39.468

99.121

0.391
  comB Streptococcus pneumoniae D39

39.468

99.121

0.391
  comB Streptococcus pneumoniae R6

39.468

99.121

0.391
  comB Streptococcus pneumoniae TIGR4

38.803

99.121

0.385
  comB Streptococcus mitis SK321

38.137

99.121

0.378
  comB Streptococcus mitis NCTC 12261

38.137

99.121

0.378