Detailed information NTG1009077

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: ABKA15_RS00015
• Genome accession: NZ_CP157941
• Coordinates: 1194..2384 (-)
• Length: 396 a.a.
• NCBI ID: WP_049512719.1
• Uniprot ID: A0A7L8W7E4
• Organism: Streptococcus sp. KHUD_010
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1..7384

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABKA15_RS00010 (ABKA15_00010)	spo0J	372..1139 (-)	768	WP_350015351.1	ParB/RepB/Spo0J family partition protein	Regulator
ABKA15_RS00015 (ABKA15_00015)	htrA	1194..2384 (-)	1191	WP_049512719.1	trypsin-like peptidase domain-containing protein	Regulator
ABKA15_RS00020 (ABKA15_00020)	rlmH	2577..3056 (+)	480	WP_049512717.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ABKA15_RS00030 (ABKA15_00030)	-	3338..3484 (+)	147	WP_003029519.1	bacteriocin	-
ABKA15_RS00035 (ABKA15_00035)	comD/comD2	3541..4827 (+)	1287	WP_225620268.1	GHKL domain-containing protein	Regulator
ABKA15_RS00040 (ABKA15_00040)	comE	4827..5576 (+)	750	WP_049512713.1	competence system response regulator transcription factor ComE	Regulator
ABKA15_RS00045 (ABKA15_00045)	-	5683..6628 (+)	946	Protein_7	IS30 family transposase	-

Sequence

Protein

• Length: 396 a.a.
• Molecular weight: 41638.61 Da
• Isoelectric Point: 9.4264

>NTDB_id=1009077 ABKA15_RS00015 WP_049512719.1 1194..2384(-) (htrA) [Streptococcus sp. KHUD_010]
MKNSSNFTKKLLLLFMVLAIGFIGGLLGNLTSSKLSTTSSTTTKVNQVTTAYKNTNSTTQAVSKVKDAVVSVITYANNNS
QNSVFGNDDSNNNNDNSQQVASEGSGVIYKKDGKYAYLVTNTHVISGAKKVDIRLADGNKVPGEIVGSDTYSDISVVRIS
ADKVKSVAEFGDSSKLTVGETAIAIGSPLGSNYANTVTQGIISSLNRNVSLKSEDGQTISTQAIQTDTAINPGNSGGPLV
NIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDVINIINQLEANGTVTRPALGIQMIDITNLSSSDLSRLKLPSKITSGV
VVRSAQSGMPAEGKLQKYDVITKVDDKEISSTSDLQSALYKHSIGDNIKITFYRDGKETTTTIKLTKSTKDLDSNN

Nucleotide

• Length: 1191 bp

>NTDB_id=1009077 ABKA15_RS00015 WP_049512719.1 1194..2384(-) (htrA) [Streptococcus sp. KHUD_010]
ATGAAAAACTCTTCAAATTTCACAAAAAAATTGTTATTGCTTTTCATGGTCTTAGCTATAGGTTTTATTGGTGGTTTACT
TGGAAACTTAACTTCATCTAAATTATCAACAACTAGCTCTACAACGACTAAAGTTAATCAAGTTACTACTGCTTATAAAA
ATACAAATTCCACAACACAAGCTGTGAGTAAAGTAAAAGATGCTGTTGTATCCGTTATTACCTATGCTAATAATAATTCA
CAAAACAGTGTGTTTGGAAATGATGATTCAAATAATAACAATGATAATTCTCAACAAGTAGCTAGCGAAGGATCTGGAGT
TATTTATAAAAAAGATGGAAAATACGCTTACTTAGTAACCAATACCCACGTTATCAGTGGTGCTAAAAAAGTTGACATTC
GTTTAGCAGATGGTAATAAAGTTCCTGGAGAAATTGTAGGGTCAGATACTTATTCTGATATCTCCGTTGTTCGCATTAGT
GCTGATAAAGTAAAATCAGTTGCTGAATTTGGAGATTCTAGCAAATTGACTGTTGGTGAGACAGCTATTGCAATTGGAAG
TCCACTTGGTTCAAATTATGCTAATACTGTGACTCAAGGAATTATTTCTAGTTTAAATCGTAATGTTTCTCTAAAATCTG
AAGACGGACAAACGATTTCAACACAAGCTATTCAAACAGACACAGCTATCAACCCAGGGAACTCTGGTGGACCACTTGTG
AATATCCAAGGGCAAGTAATTGGTATTACTTCAAGTAAAATAGCTAGCAACGGCGGAACTTCGGTTGAAGGATTAGGATT
TGCTATTCCATCTAATGATGTTATAAACATTATTAACCAGTTAGAAGCAAATGGAACTGTTACACGACCAGCTCTAGGAA
TCCAAATGATTGACATCACTAATCTGTCTAGTTCAGATCTATCACGCTTAAAACTTCCATCAAAAATAACTAGTGGAGTT
GTCGTGCGTTCAGCTCAATCTGGAATGCCAGCTGAAGGAAAACTTCAAAAATATGATGTGATTACAAAAGTAGATGATAA
AGAAATTTCTTCAACAAGTGATTTACAATCTGCTTTATACAAACATTCAATTGGCGACAACATAAAAATCACTTTCTATC
GTGATGGAAAAGAAACTACTACTACCATTAAGCTTACAAAATCTACAAAAGATTTAGATTCAAATAATTGA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (104-249)

• PDZ domain (PDZ_2) (290-385)

3D structure

• AlphaFold DB: A0A7L8W7E4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	75.561	100	0.765
htrA	Streptococcus mitis NCTC 12261	72.544	100	0.727
htrA	Streptococcus pneumoniae Rx1	72.292	100	0.725
htrA	Streptococcus pneumoniae D39	72.292	100	0.725
htrA	Streptococcus pneumoniae R6	72.292	100	0.725
htrA	Streptococcus pneumoniae TIGR4	72.292	100	0.725
htrA	Streptococcus mutans UA159	55.216	99.242	0.548