Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   ABLU28_RS03545 Genome accession   NZ_CP157495
Coordinates   696054..697280 (-) Length   408 a.a.
NCBI ID   WP_012898631.1    Uniprot ID   Q66RU3
Organism   Lactococcus lactis strain 2B-1     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 691054..702280
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ABLU28_RS03520 (ABLU28_03520) - 691193..691945 (+) 753 WP_010906333.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  ABLU28_RS03525 (ABLU28_03525) - 691986..692990 (-) 1005 WP_012898633.1 hypothetical protein -
  ABLU28_RS03530 (ABLU28_03530) - 693132..693356 (-) 225 WP_406834861.1 YkuJ family protein -
  ABLU28_RS03535 (ABLU28_03535) - 693464..694804 (-) 1341 WP_406834859.1 glycosyltransferase family 4 protein -
  ABLU28_RS03540 (ABLU28_03540) - 694930..695928 (-) 999 WP_017865166.1 glycosyltransferase family 4 protein -
  ABLU28_RS03545 (ABLU28_03545) htrA 696054..697280 (-) 1227 WP_012898631.1 S1C family serine protease Regulator
  ABLU28_RS03550 (ABLU28_03550) rlmH 697656..698135 (+) 480 WP_003130585.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  ABLU28_RS03555 (ABLU28_03555) - 698154..698852 (+) 699 WP_058218386.1 DNA alkylation repair protein -
  ABLU28_RS03560 (ABLU28_03560) yajC 698947..699279 (+) 333 WP_003130588.1 preprotein translocase subunit YajC -
  ABLU28_RS03565 (ABLU28_03565) - 699651..700385 (+) 735 WP_003130589.1 isoprenyl transferase -
  ABLU28_RS03570 (ABLU28_03570) - 700385..701188 (+) 804 WP_003130590.1 phosphatidate cytidylyltransferase -

Sequence

Protein


Download         Length: 408 a.a.        Molecular weight: 41637.93 Da        Isoelectric Point: 4.9794

>NTDB_id=1007177 ABLU28_RS03545 WP_012898631.1 696054..697280(-) (htrA) [Lactococcus lactis strain 2B-1]
MAKANIGKLLLTGVVGGAIALGGSAIYQSTTNQSANNSRSNTTSTKVSNVSVNVNTDVTSAIKKVSNSVVSVMNYQKDNS
QSSDFSSIFGGNSGSSSSTDGLQLSSEGSGVIYKKSGGDAYVVTNYHVIAGNSSLDVLLSGGQKVKASVVGYDEYTDLAV
LKISSEHVKDVATFADSSKLTIGEPAIAVGSPLGSQFANTATEGILSATSRQVTLTQENGQTTNINAIQTDAAINPGNSG
GALINIEGQVIGITQSKITTTEDGSTSVEGLGFAIPSNDVVNIINKLEADGKISRPALGIRMVDLSQLSTNDSSQLKLPS
SVTGGVVVYSVQSGLPAASAGLKAGDVITKVGDTAVTSSTDLQSALYSHNINDTVKVTYYRDGKSNTADVKLSKSTSDLE
TSSSSSSN

Nucleotide


Download         Length: 1227 bp        

>NTDB_id=1007177 ABLU28_RS03545 WP_012898631.1 696054..697280(-) (htrA) [Lactococcus lactis strain 2B-1]
ATGGCAAAAGCTAATATAGGAAAATTGCTATTAACAGGTGTCGTGGGCGGAGCCATCGCACTTGGAGGAAGTGCAATCTA
TCAAAGCACTACAAATCAATCGGCAAATAATAGTCGTTCAAATACAACTAGTACAAAGGTTAGTAACGTTTCGGTAAATG
TCAATACCGATGTTACCTCTGCAATTAAAAAAGTTTCAAATTCTGTCGTTTCTGTTATGAATTATCAAAAAGATAACTCA
CAAAGTAGTGACTTCAGTTCAATTTTTGGTGGAAATAGCGGTTCAAGTTCATCAACTGATGGCTTACAGCTTTCTAGTGA
AGGCTCTGGTGTCATCTACAAAAAATCTGGTGGTGATGCCTACGTTGTAACTAACTACCACGTTATTGCTGGTAATAGCT
CACTTGATGTTCTGCTTTCTGGTGGACAAAAAGTCAAAGCTTCTGTGGTTGGTTATGATGAATACACAGACCTTGCTGTT
CTTAAAATCAGTTCTGAACATGTCAAAGATGTGGCGACATTCGCTGATTCTAGTAAATTAACAATTGGTGAACCTGCCAT
TGCCGTTGGCTCACCTTTAGGTAGTCAATTTGCAAACACCGCAACTGAAGGAATTTTATCTGCAACAAGCCGTCAAGTGA
CTTTGACCCAAGAAAATGGTCAAACAACTAATATCAATGCAATTCAAACAGATGCTGCCATTAACCCTGGTAACTCTGGA
GGGGCTTTGATTAATATTGAAGGGCAAGTTATTGGAATTACTCAAAGTAAAATTACAACAACTGAAGATGGTTCTACTTC
TGTCGAAGGTTTAGGATTTGCGATTCCTTCTAATGATGTCGTAAATATCATTAATAAACTTGAAGCTGATGGTAAGATTT
CACGCCCTGCTTTAGGTATCCGAATGGTTGACCTTTCACAATTATCAACAAATGACAGTTCTCAATTGAAACTACCAAGC
AGTGTAACAGGTGGGGTAGTTGTTTACTCCGTCCAATCTGGACTTCCTGCTGCCTCAGCTGGTTTGAAAGCTGGAGATGT
AATTACAAAGGTTGGCGATACAGCAGTAACTTCTTCAACAGACTTGCAAAGTGCTCTTTACTCACACAACATCAATGATA
CAGTAAAAGTTACTTATTATCGTGATGGTAAATCAAATACAGCAGATGTTAAACTTTCTAAATCAACCAGTGACTTAGAA
ACAAGCAGTTCATCTTCTTCTAATTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(296-392)

Peptidase family M50 (Peptidase_M50)

(250-396)

Trypsin-like peptidase domain (Trypsin_2)

(108-253)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q66RU3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

56.283

93.627

0.527
  htrA Streptococcus gordonii str. Challis substr. CH1

54.476

95.833

0.522
  htrA Streptococcus pneumoniae D39

58.309

84.069

0.49
  htrA Streptococcus pneumoniae TIGR4

58.309

84.069

0.49
  htrA Streptococcus pneumoniae R6

58.309

84.069

0.49
  htrA Streptococcus pneumoniae Rx1

58.309

84.069

0.49
  htrA Streptococcus mutans UA159

52.989

90.196

0.478

Multiple sequence alignment