Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | ralRA/- |
Location | 1413556..1413927 | Replicon | chromosome |
Accession | NZ_CP026357 | ||
Organism | Escherichia coli strain 2F_0 |
Toxin (Protein)
Gene name | ralR | Uniprot ID | F4VC37 |
Locus tag | C2R04_RS07445 | Protein ID | WP_001317028.1 |
Coordinates | 1413733..1413927 (-) | Length | 65 a.a. |
Antitoxin (RNA)
Gene name | ralA | ||
Locus tag | - | ||
Coordinates | 1413556..1413734 (+) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
C2R04_RS07420 | 1409511..1410884 | + | 1374 | WP_000123737.1 | ATP-dependent RNA helicase DbpA | - |
C2R04_RS07425 | 1411013..1411948 | - | 936 | WP_001157406.1 | tRNA 2-thiocytidine(32) synthetase TtcA | - |
C2R04_RS07430 | 1412000..1413235 | - | 1236 | WP_000040852.1 | site-specific integrase | - |
C2R04_RS07435 | 1413237..1413452 | - | 216 | WP_000079604.1 | excisionase XisR | - |
C2R04_RS07440 | 1413531..1413740 | - | 210 | WP_000276809.1 | double-strand break reduction protein RcbA | - |
- | 1413556..1413734 | + | 179 | NuclAT_0 | - | Antitoxin |
- | 1413556..1413734 | + | 179 | NuclAT_0 | - | Antitoxin |
- | 1413556..1413734 | + | 179 | NuclAT_0 | - | Antitoxin |
- | 1413556..1413734 | + | 179 | NuclAT_0 | - | Antitoxin |
C2R04_RS07445 | 1413733..1413927 | - | 195 | WP_001317028.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
C2R04_RS07450 | 1413984..1414793 | - | 810 | WP_000166319.1 | recombination protein RecT | - |
C2R04_RS07455 | 1414786..1417386 | - | 2601 | WP_000105143.1 | exodeoxyribonuclease VIII | - |
C2R04_RS07460 | 1417488..1417763 | - | 276 | WP_000632297.1 | protein RacC | - |
C2R04_RS07465 | 1417838..1418008 | - | 171 | WP_001352098.1 | conserved protein, Rac prophage | - |
C2R04_RS07470 | 1418008..1418229 | - | 222 | WP_000560225.1 | killing protein KilR | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Prophage | - | - | 1412000..1433674 | 21674 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 65 a.a. Molecular weight: 7018.89 Da Isoelectric Point: 8.9538
>T94500 WP_001317028.1 NZ_CP026357:c1413927-1413733 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV
Download Length: 195 bp
>T94500 NZ_CP026357:c1413927-1413733 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA
Antitoxin
Download Length: 179 bp
>AT94500 NZ_CP026357:1413556-1413734 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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