Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ralRA/-
Location 1411580..1411951 Replicon chromosome
Accession NZ_CP026026
Organism Escherichia coli strain CAR

Toxin (Protein)


Gene name ralR Uniprot ID F4VC37
Locus tag C2H81_RS07435 Protein ID WP_001317028.1
Coordinates 1411757..1411951 (-) Length 65 a.a.

Antitoxin (RNA)


Gene name ralA
Locus tag -
Coordinates 1411580..1411758 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C2H81_RS07410 1407535..1408908 + 1374 WP_000123737.1 ATP-dependent RNA helicase DbpA -
C2H81_RS07415 1409037..1409972 - 936 WP_001157406.1 tRNA 2-thiocytidine(32) synthetase TtcA -
C2H81_RS07420 1410024..1411259 - 1236 WP_000040852.1 site-specific integrase -
C2H81_RS07425 1411261..1411476 - 216 WP_000079604.1 excisionase XisR -
C2H81_RS07430 1411555..1411764 - 210 WP_000276809.1 double-strand break reduction protein RcbA -
- 1411580..1411758 + 179 NuclAT_0 - Antitoxin
- 1411580..1411758 + 179 NuclAT_0 - Antitoxin
- 1411580..1411758 + 179 NuclAT_0 - Antitoxin
- 1411580..1411758 + 179 NuclAT_0 - Antitoxin
C2H81_RS07435 1411757..1411951 - 195 WP_001317028.1 type I toxin-antitoxin system endodeoxyribonuclease toxin RalR Toxin
C2H81_RS07440 1412008..1412817 - 810 WP_000166319.1 recombination protein RecT -
C2H81_RS07445 1412810..1415410 - 2601 WP_000105143.1 exodeoxyribonuclease VIII -
C2H81_RS07450 1415512..1415787 - 276 WP_000632297.1 protein RacC -
C2H81_RS07455 1415862..1416032 - 171 WP_001352098.1 conserved protein, Rac prophage -
C2H81_RS07460 1416032..1416253 - 222 WP_000560225.1 killing protein KilR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1410024..1431698 21674


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endodeoxyribonuclease toxin RalR

(6-54)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7018.89 Da        Isoelectric Point: 8.9538

>T92756 WP_001317028.1 NZ_CP026026:c1411951-1411757 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Download         Length: 195 bp

>T92756 NZ_CP026026:c1411951-1411757 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 179 bp

>AT92756 NZ_CP026026:1411580-1411758 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHV7

Antitoxin

Download structure file

References