Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 433510..434069 Replicon chromosome
Accession NZ_CP013320
Organism Vibrio cholerae strain NCTC9420

Toxin (Protein)


Gene name relE Uniprot ID Q9K2M8
Locus tag ASZ86_RS16830 Protein ID WP_000578476.1
Coordinates 433510..433788 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9L991
Locus tag ASZ86_RS16835 Protein ID WP_000381183.1
Coordinates 433785..434069 (-) Length 95 a.a.

Genomic Context

ASZ86_RS16780ASZ86_RS16785ASZ86_RS16795ASZ86_RS16800ASZ86_RS20565ASZ86_RS16805ASZ86_RS16810ASZ86_RS20570ASZ86_RS16825ASZ86_RS16840ASZ86_RS16845ASZ86_RS16860ASZ86_RS16830ASZ86_RS16835
Location: 428810..429247 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 429311..429529 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 429704..430576 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 430726..431325 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 431382..431486 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 431517..431786 (270 bp)
Type: Others
Protein ID: WP_001114075.1
Location: 431780..432301 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 432600..432725 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 432976..433371 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 434263..434778 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 434962..435375 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 435930..437107 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 433510..433788 (279 bp)
Type: Toxin
Protein ID: WP_000578476.1
Location: 433785..434069 (285 bp)
Type: Antitoxin
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ86_RS16780428810..429247+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
ASZ86_RS16785429311..429529+219WP_071908318.1GNAT family N-acetyltransferase-
ASZ86_RS16795429704..430576+873WP_000254716.1DUF3800 domain-containing protein-
ASZ86_RS16800430726..431325+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
ASZ86_RS20565431382..431486+105WP_099607150.1acetyltransferase-
ASZ86_RS16805431517..431786+270WP_001114075.1DUF4160 domain-containing protein-
ASZ86_RS16810431780..432301+522WP_000921691.1DUF2442 domain-containing protein-
ASZ86_RS20570432600..432725+126WP_001905700.1DUF645 family protein-
ASZ86_RS16825432976..433371+396WP_001000867.1hypothetical protein-
ASZ86_RS16830433510..433788-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
ASZ86_RS16835433785..434069-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
ASZ86_RS16840434263..434778+516WP_000343779.1GNAT family N-acetyltransferase-
ASZ86_RS16845434962..435375+414WP_000049420.1VOC family protein-
ASZ86_RS16860435930..437107+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--304702..436238131536
-insideIntegron--309782..435862126080
flankIS/Tn--428810..429247437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(2-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-70)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10819.59 Da        Isoelectric Point: 5.1651

>T58432 WP_000578476.1 NZ_CP013320:c433788-433510 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAKKTDELIEAKVENLLEQPLIGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Download         Length: 279 bp

>T58432 NZ_CP013320:c433788-433510 [Vibrio cholerae]
ATGATTTTCTGGGAAGAAGCATCTCTCAATGATCGTGAGAAAATTTTCGAATTTCTCTACGACTTTAACCCAGCAGCGGC
TAAAAAAACGGATGAGCTCATAGAAGCCAAAGTCGAAAATTTGCTTGAGCAACCACTAATCGGTGTTCAGCGTGATGGCA
TTAGAGGCAGATTGCTTATTATCCCTGAGATATCAATGATTGTTTCGTATTGGGTTGATGGTTCTAAAATTCGAATAATG
CGTGTACTACATCAGAAACAAAAATTTCCAAACGACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10901.25 Da        Isoelectric Point: 8.0775

>AT58432 WP_000381183.1 NZ_CP013320:c434069-433785 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Download         Length: 285 bp

>AT58432 NZ_CP013320:c434069-433785 [Vibrio cholerae]
ATGGATACTAGAATTCAATTTCGTGTAGACGAAGAAACAAAACGTTTAGCTCAACAAATGGCTGAAAGCCAAGGTCGAAC
TCTTAGCGATGCTTGCCGTGAACTCACTGAACAATTAGCTGAGCAGCAACGCAAGGCATTATCTCACGATGCATGGCTAA
CTGAACAAGTGAATCAAGCATTTGAGAAGTTCGACTCAGGAAAAGCAGTATTCATTGAACATGACATCGCCAAAGCACGA
ATGGCTGAACGTAAAGCTAAAATCCGAAATCGAGGCCACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBQ9K2M8

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A067BL33

References