Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 431382..431786 Replicon chromosome
Accession NZ_CP013320
Organism Vibrio cholerae strain NCTC9420

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag ASZ86_RS16805 Protein ID WP_001114075.1
Coordinates 431517..431786 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag ASZ86_RS20565 Protein ID WP_099607150.1
Coordinates 431382..431486 (+) Length 35 a.a.

Genomic Context

ASZ86_RS16760ASZ86_RS16770ASZ86_RS16775ASZ86_RS16780ASZ86_RS16785ASZ86_RS16795ASZ86_RS16800ASZ86_RS20565ASZ86_RS16805ASZ86_RS16810ASZ86_RS20570ASZ86_RS16825ASZ86_RS16840ASZ86_RS16845ASZ86_RS16830ASZ86_RS16835
Location: 426883..427800 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 427957..428346 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 428482..428691 (210 bp)
Type: Others
Protein ID: Protein_467
Location: 428810..429247 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 429311..429529 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 429704..430576 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 430726..431325 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 431382..431486 (105 bp)
Type: Antitoxin
Protein ID: WP_099607150.1
Location: 431517..431786 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 431780..432301 (522 bp)
Type: Others
Protein ID: WP_000921691.1
Location: 432600..432725 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 432976..433371 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 434263..434778 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 434962..435375 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 433510..433788 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 433785..434069 (285 bp)
Type: Others
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ86_RS16760426883..427800+918WP_000186333.1alpha/beta hydrolase-
ASZ86_RS16770427957..428346+390WP_001081302.1hypothetical protein-
ASZ86_RS16775428482..428691+210Protein_467GNAT family N-acetyltransferase-
ASZ86_RS16780428810..429247+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
ASZ86_RS16785429311..429529+219WP_071908318.1GNAT family N-acetyltransferase-
ASZ86_RS16795429704..430576+873WP_000254716.1DUF3800 domain-containing protein-
ASZ86_RS16800430726..431325+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
ASZ86_RS20565431382..431486+105WP_099607150.1acetyltransferaseAntitoxin
ASZ86_RS16805431517..431786+270WP_001114075.1DUF4160 domain-containing proteinToxin
ASZ86_RS16810431780..432301+522WP_000921691.1DUF2442 domain-containing protein-
ASZ86_RS20570432600..432725+126WP_001905700.1DUF645 family protein-
ASZ86_RS16825432976..433371+396WP_001000867.1hypothetical protein-
ASZ86_RS16830433510..433788-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
ASZ86_RS16835433785..434069-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
ASZ86_RS16840434263..434778+516WP_000343779.1GNAT family N-acetyltransferase-
ASZ86_RS16845434962..435375+414WP_000049420.1VOC family protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--304702..436238131536
-insideIntegron--309782..435862126080
flankIS/Tn--428810..429247437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T58430 WP_001114075.1 NZ_CP013320:431517-431786 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T58430 NZ_CP013320:431517-431786 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT58430 WP_099607150.1 NZ_CP013320:431382-431486 [Vibrio cholerae]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT58430 NZ_CP013320:431382-431486 [Vibrio cholerae]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

Loading, please wait
Source
ID
Structure
No matching records found

References