58429

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 426102..426649 Replicon chromosome
Accession NZ_CP013320
Organism Vibrio cholerae strain NCTC9420

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag ASZ86_RS16755 Protein ID WP_000229317.1
Coordinates 426347..426649 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag ASZ86_RS16750 Protein ID WP_000861987.1
Coordinates 426102..426359 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ86_RS16700 421131..421586 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
ASZ86_RS16710 421908..422060 + 153 WP_001884520.1 DUF645 family protein -
ASZ86_RS16715 422262..422759 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
ASZ86_RS16720 422756..423028 - 273 WP_000246253.1 DUF1778 domain-containing protein -
ASZ86_RS16725 423259..423927 + 669 WP_000043871.1 hypothetical protein -
ASZ86_RS16730 424079..424366 + 288 WP_000426470.1 hypothetical protein -
ASZ86_RS16735 424507..424878 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
ASZ86_RS16740 424945..425370 + 426 WP_001882332.1 DUF1778 domain-containing protein -
ASZ86_RS16745 425367..425900 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
ASZ86_RS16750 426102..426359 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASZ86_RS16755 426347..426649 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ86_RS16760 426883..427800 + 918 WP_000186333.1 alpha/beta hydrolase -
ASZ86_RS16770 427957..428346 + 390 WP_001081302.1 hypothetical protein -
ASZ86_RS16775 428482..428691 + 210 Protein_467 GNAT family N-acetyltransferase -
ASZ86_RS16780 428810..429247 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
ASZ86_RS16785 429311..429529 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
ASZ86_RS16795 429704..430576 + 873 WP_000254716.1 DUF3800 domain-containing protein -
ASZ86_RS16800 430726..431325 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
ASZ86_RS20565 431382..431486 + 105 WP_099607150.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 304702..436238 131536
- inside Integron - - 309782..435862 126080
flank IS/Tn - - 428810..429247 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T58429 WP_000229317.1 NZ_CP013320:426347-426649 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T58429 NZ_CP013320:426347-426649 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT58429 WP_000861987.1 NZ_CP013320:426102-426359 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT58429 NZ_CP013320:426102-426359 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References