Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 426102..426649 Replicon chromosome
Accession NZ_CP013320
Organism Vibrio cholerae strain NCTC9420

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag ASZ86_RS16755 Protein ID WP_000229317.1
Coordinates 426347..426649 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag ASZ86_RS16750 Protein ID WP_000861987.1
Coordinates 426102..426359 (+) Length 86 a.a.

Genomic Context

ASZ86_RS16700ASZ86_RS16710ASZ86_RS16725ASZ86_RS16730ASZ86_RS16735ASZ86_RS16740ASZ86_RS16745ASZ86_RS16750ASZ86_RS16755ASZ86_RS16760ASZ86_RS16770ASZ86_RS16775ASZ86_RS16780ASZ86_RS16785ASZ86_RS16795ASZ86_RS16800ASZ86_RS20565ASZ86_RS16715ASZ86_RS16720
Location: 421131..421586 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 421908..422060 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 423259..423927 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 424079..424366 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 424507..424878 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 424945..425370 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 425367..425900 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 426102..426359 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 426347..426649 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 426883..427800 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 427957..428346 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 428482..428691 (210 bp)
Type: Others
Protein ID: Protein_467
Location: 428810..429247 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 429311..429529 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 429704..430576 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 430726..431325 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 431382..431486 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 422262..422759 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 422756..423028 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ86_RS16700421131..421586+456WP_001245327.1GNAT family N-acetyltransferase-
ASZ86_RS16710421908..422060+153WP_001884520.1DUF645 family protein-
ASZ86_RS16715422262..422759-498WP_000982260.1GNAT family N-acetyltransferase-
ASZ86_RS16720422756..423028-273WP_000246253.1DUF1778 domain-containing protein-
ASZ86_RS16725423259..423927+669WP_000043871.1hypothetical protein-
ASZ86_RS16730424079..424366+288WP_000426470.1hypothetical protein-
ASZ86_RS16735424507..424878+372WP_001164080.1nucleotide pyrophosphohydrolase-
ASZ86_RS16740424945..425370+426WP_001882332.1DUF1778 domain-containing protein-
ASZ86_RS16745425367..425900+534WP_000118351.1GNAT family N-acetyltransferase-
ASZ86_RS16750426102..426359+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ASZ86_RS16755426347..426649+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ86_RS16760426883..427800+918WP_000186333.1alpha/beta hydrolase-
ASZ86_RS16770427957..428346+390WP_001081302.1hypothetical protein-
ASZ86_RS16775428482..428691+210Protein_467GNAT family N-acetyltransferase-
ASZ86_RS16780428810..429247+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
ASZ86_RS16785429311..429529+219WP_071908318.1GNAT family N-acetyltransferase-
ASZ86_RS16795429704..430576+873WP_000254716.1DUF3800 domain-containing protein-
ASZ86_RS16800430726..431325+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
ASZ86_RS20565431382..431486+105WP_099607150.1acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--304702..436238131536
-insideIntegron--309782..435862126080
flankIS/Tn--428810..429247437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T58429 WP_000229317.1 NZ_CP013320:426347-426649 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T58429 NZ_CP013320:426347-426649 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT58429 WP_000861987.1 NZ_CP013320:426102-426359 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT58429 NZ_CP013320:426102-426359 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References