Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 422262..423028 Replicon chromosome
Accession NZ_CP013320
Organism Vibrio cholerae strain NCTC9420

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag ASZ86_RS16715 Protein ID WP_000982260.1
Coordinates 422262..422759 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag ASZ86_RS16720 Protein ID WP_000246253.1
Coordinates 422756..423028 (-) Length 91 a.a.

Genomic Context

ASZ86_RS16665ASZ86_RS16670ASZ86_RS16675ASZ86_RS20545ASZ86_RS16685ASZ86_RS16690ASZ86_RS16695ASZ86_RS16700ASZ86_RS16710ASZ86_RS16725ASZ86_RS16730ASZ86_RS16735ASZ86_RS16740ASZ86_RS16745ASZ86_RS16750ASZ86_RS16755ASZ86_RS16760ASZ86_RS16715ASZ86_RS16720
Location: 418124..418430 (307 bp)
Type: Others
Protein ID: Protein_447
Location: 418567..419259 (693 bp)
Type: Others
Protein ID: WP_001047169.1
Location: 419259..419660 (402 bp)
Type: Others
Protein ID: WP_000351248.1
Location: 419630..419773 (144 bp)
Type: Others
Protein ID: WP_071908341.1
Location: 419848..420261 (414 bp)
Type: Others
Protein ID: WP_000049417.1
Location: 420475..420726 (252 bp)
Type: Others
Protein ID: WP_001250179.1
Location: 420716..421003 (288 bp)
Type: Others
Protein ID: WP_000221354.1
Location: 421131..421586 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 421908..422060 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 423259..423927 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 424079..424366 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 424507..424878 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 424945..425370 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 425367..425900 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 426102..426359 (258 bp)
Type: Others
Protein ID: WP_000861987.1
Location: 426347..426649 (303 bp)
Type: Others
Protein ID: WP_000229317.1
Location: 426883..427800 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 422262..422759 (498 bp)
Type: Toxin
Protein ID: WP_000982260.1
Location: 422756..423028 (273 bp)
Type: Antitoxin
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ86_RS16665418124..418430+307Protein_447CatB-related O-acetyltransferase-
ASZ86_RS16670418567..419259+693WP_001047169.1GNAT family N-acetyltransferase-
ASZ86_RS16675419259..419660+402WP_000351248.1type II toxin-antitoxin system death-on-curing family toxin-
ASZ86_RS20545419630..419773+144WP_071908341.1DUF3265 domain-containing protein-
ASZ86_RS16685419848..420261+414WP_000049417.1VOC family protein-
ASZ86_RS16690420475..420726+252WP_001250179.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ86_RS16695420716..421003+288WP_000221354.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ86_RS16700421131..421586+456WP_001245327.1GNAT family N-acetyltransferase-
ASZ86_RS16710421908..422060+153WP_001884520.1DUF645 family protein-
ASZ86_RS16715422262..422759-498WP_000982260.1GNAT family N-acetyltransferaseToxin
ASZ86_RS16720422756..423028-273WP_000246253.1DUF1778 domain-containing proteinAntitoxin
ASZ86_RS16725423259..423927+669WP_000043871.1hypothetical protein-
ASZ86_RS16730424079..424366+288WP_000426470.1hypothetical protein-
ASZ86_RS16735424507..424878+372WP_001164080.1nucleotide pyrophosphohydrolase-
ASZ86_RS16740424945..425370+426WP_001882332.1DUF1778 domain-containing protein-
ASZ86_RS16745425367..425900+534WP_000118351.1GNAT family N-acetyltransferase-
ASZ86_RS16750426102..426359+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxin-
ASZ86_RS16755426347..426649+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxin-
ASZ86_RS16760426883..427800+918WP_000186333.1alpha/beta hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--304702..436238131536
-insideIntegron--309782..435862126080
flankIS/Tn--417076..418056980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T58427 WP_000982260.1 NZ_CP013320:c422759-422262 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T58427 NZ_CP013320:c422759-422262 [Vibrio cholerae]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT58427 WP_000246253.1 NZ_CP013320:c423028-422756 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT58427 NZ_CP013320:c423028-422756 [Vibrio cholerae]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A0Q0KGB1

Antitoxin

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Source
ID
Structure
PDB1Y9B
AlphaFold DBA0A0F2IC79

References