Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-YafN |
Location | 420475..421003 | Replicon | chromosome |
Accession | NZ_CP013320 | ||
Organism | Vibrio cholerae strain NCTC9420 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A0X1KZS6 |
Locus tag | ASZ86_RS16695 | Protein ID | WP_000221354.1 |
Coordinates | 420716..421003 (+) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A0X1KZS8 |
Locus tag | ASZ86_RS16690 | Protein ID | WP_001250179.1 |
Coordinates | 420475..420726 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
ASZ86_RS16640 | 415743..416057 | + | 315 | WP_000071008.1 | DNA-binding transcriptional regulator | - |
ASZ86_RS16645 | 416194..416628 | + | 435 | WP_000256036.1 | GNAT family N-acetyltransferase | - |
ASZ86_RS20650 | 416796..416951 | + | 156 | WP_000751734.1 | hypothetical protein | - |
ASZ86_RS16660 | 417076..418056 | - | 981 | WP_000019370.1 | IS5-like element ISVch5 family transposase | - |
ASZ86_RS16665 | 418124..418430 | + | 307 | Protein_447 | CatB-related O-acetyltransferase | - |
ASZ86_RS16670 | 418567..419259 | + | 693 | WP_001047169.1 | GNAT family N-acetyltransferase | - |
ASZ86_RS16675 | 419259..419660 | + | 402 | WP_000351248.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
ASZ86_RS20545 | 419630..419773 | + | 144 | WP_071908341.1 | DUF3265 domain-containing protein | - |
ASZ86_RS16685 | 419848..420261 | + | 414 | WP_000049417.1 | VOC family protein | - |
ASZ86_RS16690 | 420475..420726 | + | 252 | WP_001250179.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
ASZ86_RS16695 | 420716..421003 | + | 288 | WP_000221354.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
ASZ86_RS16700 | 421131..421586 | + | 456 | WP_001245327.1 | GNAT family N-acetyltransferase | - |
ASZ86_RS16710 | 421908..422060 | + | 153 | WP_001884520.1 | DUF645 family protein | - |
ASZ86_RS16715 | 422262..422759 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
ASZ86_RS16720 | 422756..423028 | - | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
ASZ86_RS16725 | 423259..423927 | + | 669 | WP_000043871.1 | hypothetical protein | - |
ASZ86_RS16730 | 424079..424366 | + | 288 | WP_000426470.1 | hypothetical protein | - |
ASZ86_RS16735 | 424507..424878 | + | 372 | WP_001164080.1 | nucleotide pyrophosphohydrolase | - |
ASZ86_RS16740 | 424945..425370 | + | 426 | WP_001882332.1 | DUF1778 domain-containing protein | - |
ASZ86_RS16745 | 425367..425900 | + | 534 | WP_000118351.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 304702..436238 | 131536 | |
- | inside | Integron | - | - | 309782..435862 | 126080 | |
flank | IS/Tn | - | - | 417076..418056 | 980 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10991.96 Da Isoelectric Point: 10.4934
>T58426 WP_000221354.1 NZ_CP013320:420716-421003 [Vibrio cholerae]
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG
MTYKLKFLPAAQKEWSKLAPTIQSQFKKKLKERLENPHVPSAKLRGYDAVYKIKLRTAGYRLAYEVIDDEIVVYVLAVGK
RDKDAVYKKLASRFG
Download Length: 288 bp
>T58426 NZ_CP013320:420716-421003 [Vibrio cholerae]
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG
ATGACCTATAAGTTAAAGTTTCTGCCGGCTGCGCAAAAGGAATGGAGTAAGTTAGCTCCGACAATTCAGAGTCAGTTCAA
GAAGAAGTTAAAGGAACGATTAGAAAATCCGCACGTCCCTTCGGCTAAGCTTCGAGGATACGACGCTGTTTACAAGATTA
AACTTCGTACGGCGGGTTATCGTTTAGCTTATGAGGTTATTGACGATGAGATAGTTGTCTATGTCCTTGCTGTCGGTAAA
CGTGACAAAGATGCTGTCTATAAAAAACTGGCTTCACGCTTCGGTTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9136.29 Da Isoelectric Point: 4.0197
>AT58426 WP_001250179.1 NZ_CP013320:420475-420726 [Vibrio cholerae]
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL
MRQVLANCSASISELKKNPTALLNEADGSAIAILNHNKPAAYLVPAETYEYLIDMLDDYELSQIVDSRRADLAQAVEVNI
DDL
Download Length: 252 bp
>AT58426 NZ_CP013320:420475-420726 [Vibrio cholerae]
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA
ATGAGACAAGTTTTAGCGAATTGCTCTGCAAGTATTTCAGAGTTAAAGAAGAACCCAACAGCTTTGTTGAATGAGGCTGA
TGGGTCTGCAATTGCAATTTTAAACCACAACAAGCCAGCGGCTTACCTTGTGCCAGCGGAAACGTATGAGTATCTCATCG
ATATGCTCGATGATTATGAGCTTTCCCAAATTGTCGATAGTCGCCGAGCTGACTTAGCACAAGCTGTGGAAGTAAATATT
GATGACCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0X1KZS6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0X1KZS8 |