58425

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-GNAT
Location 418567..419660 Replicon chromosome
Accession NZ_CP013320
Organism Vibrio cholerae strain NCTC9420

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag ASZ86_RS16675 Protein ID WP_000351248.1
Coordinates 419259..419660 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag ASZ86_RS16670 Protein ID WP_001047169.1
Coordinates 418567..419259 (+) Length 231 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ86_RS16600 413850..414227 + 378 WP_071919850.1 hypothetical protein -
ASZ86_RS20810 414284..414398 + 115 Protein_438 acetyltransferase -
ASZ86_RS16605 414347..414628 + 282 WP_001894453.1 DUF1289 domain-containing protein -
ASZ86_RS16620 414794..414907 + 114 WP_001889158.1 hypothetical protein -
ASZ86_RS16625 414856..415083 + 228 WP_001894457.1 DUF1289 domain-containing protein -
ASZ86_RS16635 415424..415756 + 333 WP_000843587.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ86_RS16640 415743..416057 + 315 WP_000071008.1 DNA-binding transcriptional regulator -
ASZ86_RS16645 416194..416628 + 435 WP_000256036.1 GNAT family N-acetyltransferase -
ASZ86_RS20650 416796..416951 + 156 WP_000751734.1 hypothetical protein -
ASZ86_RS16660 417076..418056 - 981 WP_000019370.1 IS5-like element ISVch5 family transposase -
ASZ86_RS16665 418124..418430 + 307 Protein_447 CatB-related O-acetyltransferase -
ASZ86_RS16670 418567..419259 + 693 WP_001047169.1 GNAT family N-acetyltransferase Antitoxin
ASZ86_RS16675 419259..419660 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
ASZ86_RS20545 419630..419773 + 144 WP_071908341.1 DUF3265 domain-containing protein -
ASZ86_RS16685 419848..420261 + 414 WP_000049417.1 VOC family protein -
ASZ86_RS16690 420475..420726 + 252 WP_001250179.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
ASZ86_RS16695 420716..421003 + 288 WP_000221354.1 type II toxin-antitoxin system RelE/ParE family toxin -
ASZ86_RS16700 421131..421586 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
ASZ86_RS16710 421908..422060 + 153 WP_001884520.1 DUF645 family protein -
ASZ86_RS16715 422262..422759 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
ASZ86_RS16720 422756..423028 - 273 WP_000246253.1 DUF1778 domain-containing protein -
ASZ86_RS16725 423259..423927 + 669 WP_000043871.1 hypothetical protein -
ASZ86_RS16730 424079..424366 + 288 WP_000426470.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 304702..436238 131536
- inside Integron - - 309782..435862 126080
flank IS/Tn - - 417076..418056 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin

GNAT domain

(36-153)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T58425 WP_000351248.1 NZ_CP013320:419259-419660 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T58425 NZ_CP013320:419259-419660 [Vibrio cholerae]
ATGGATATCATCTGTTTTCCTTTTGAACGAGTGATCGAGATTAATGCTTTCATCCTAAAAACAGAACCAGGAATGAAAGG
AGCCGTTGATATTCCCAAGCTTCAGGGGGCATTAGGTCGAATCGATAATGCCATCGTTTATGAAGGACTGGATGATGTTT
TTGAAATCGCTGCTAAATACACTGCTTGTATAGCGGTTTCACATGCGCTACCTGATGCGAACAAACGCACAGGTTTGGCT
GTGGCACTTGAATATTTATCACTTAACGATTTTGAGCTTACGCAGGAAAACGATTTACTTGCGGATGCAGTTCGAGATCT
TGTTATCGGCATTATCAACGAAACAGATTTTGCCGACATTCTCTACGCACAATACGCAAAAGAACAAAATTCAGCTCTCT
AA

Antitoxin


Download         Length: 231 a.a.        Molecular weight: 26352.73 Da        Isoelectric Point: 8.5633

>AT58425 WP_001047169.1 NZ_CP013320:418567-419259 [Vibrio cholerae]
MNLEEFQESDFDLLIKWIDSDELNYLWGCPAYVFPLTYEQIHSHCSKAEVFPYLLKVKGRHAGFVELYKVTDEQYRICRV
FISNAYRGQGLSKSMLMLLIDKARLDFSATKLSLGVFEQNTVARKCYESLGFEVVMVVVIEFGGMRCQPLRRALCFLSRF
GAIIGLTFIDSRCDMNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 693 bp

>AT58425 NZ_CP013320:418567-419259 [Vibrio cholerae]
ATGAACTTAGAAGAGTTTCAAGAATCGGATTTTGACCTGCTTATAAAATGGATTGACTCAGATGAGTTGAACTATTTATG
GGGTTGCCCTGCGTATGTTTTCCCGCTGACTTATGAACAGATCCATTCCCACTGTAGCAAAGCGGAAGTATTTCCCTATC
TGCTAAAAGTGAAAGGTAGACATGCCGGGTTTGTTGAGTTGTACAAAGTCACCGATGAGCAATATCGGATTTGCCGTGTC
TTTATTTCAAATGCTTATCGTGGGCAAGGGCTATCAAAATCGATGTTGATGTTATTAATCGATAAAGCCCGATTAGATTT
TTCTGCAACCAAGCTTAGCTTAGGCGTTTTTGAACAGAACACAGTTGCTAGAAAATGCTATGAGTCATTAGGTTTTGAAG
TGGTTATGGTTGTTGTGATTGAGTTTGGCGGTATGCGTTGTCAGCCCCTTAGGCGGGCGTTATGTTTTTTATCACGTTTT
GGGGCTATAATCGGCCTAACCTTTATTGATAGTAGGTGTGATATGAATCGAAAAGTTGAAGCTTACGGCGTTGATGCTGT
TGAAAGACCGAAAATTAAGGCTAGTAAAAAGCTTGATTTGACTGGTGATGCTGGTCGTCAAATTGTGAAGTCTGAAACTA
AACTTGCTTTGCGTACTCATCAGAAGACATTCACTAAATTGGCTGATATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34

Antitoxin

Source ID Structure

References