Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/-
Location 838813..839597 Replicon chromosome
Accession NZ_CP013312
Organism Vibrio cholerae strain E1320

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag ASZ88_RS18570 Protein ID WP_001114075.1
Coordinates 838813..839082 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID Q9KM84
Locus tag ASZ88_RS18575 Protein ID WP_000921691.1
Coordinates 839076..839597 (+) Length 174 a.a.

Genomic Context

ASZ88_RS18525ASZ88_RS18535ASZ88_RS18540ASZ88_RS18545ASZ88_RS18550ASZ88_RS18560ASZ88_RS18565ASZ88_RS20900ASZ88_RS18570ASZ88_RS18575ASZ88_RS20905ASZ88_RS18590ASZ88_RS18605ASZ88_RS18610ASZ88_RS18625ASZ88_RS18595ASZ88_RS18600
Location: 834179..835096 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 835253..835642 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 835778..835987 (210 bp)
Type: Others
Protein ID: Protein_855
Location: 836106..836543 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 836607..836825 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 837000..837872 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 838022..838621 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 838678..838782 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 838813..839082 (270 bp)
Type: Toxin
Protein ID: WP_001114075.1
Location: 839076..839597 (522 bp)
Type: Antitoxin
Protein ID: WP_000921691.1
Location: 839896..840021 (126 bp)
Type: Others
Protein ID: WP_001905700.1
Location: 840272..840667 (396 bp)
Type: Others
Protein ID: WP_001000867.1
Location: 841559..842074 (516 bp)
Type: Others
Protein ID: WP_000343779.1
Location: 842258..842671 (414 bp)
Type: Others
Protein ID: WP_000049420.1
Location: 843226..844403 (1178 bp)
Type: Others
Protein ID: WP_086010879.1
Location: 840806..841084 (279 bp)
Type: Others
Protein ID: WP_000578476.1
Location: 841081..841365 (285 bp)
Type: Others
Protein ID: WP_000381183.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ88_RS18525834179..835096+918WP_000186333.1alpha/beta hydrolase-
ASZ88_RS18535835253..835642+390WP_001081302.1hypothetical protein-
ASZ88_RS18540835778..835987+210Protein_855GNAT family N-acetyltransferase-
ASZ88_RS18545836106..836543+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
ASZ88_RS18550836607..836825+219WP_071908318.1GNAT family N-acetyltransferase-
ASZ88_RS18560837000..837872+873WP_000254716.1DUF3800 domain-containing protein-
ASZ88_RS18565838022..838621+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
ASZ88_RS20900838678..838782+105WP_099607150.1acetyltransferase-
ASZ88_RS18570838813..839082+270WP_001114075.1DUF4160 domain-containing proteinToxin
ASZ88_RS18575839076..839597+522WP_000921691.1DUF2442 domain-containing proteinAntitoxin
ASZ88_RS20905839896..840021+126WP_001905700.1DUF645 family protein-
ASZ88_RS18590840272..840667+396WP_001000867.1hypothetical protein-
ASZ88_RS18595840806..841084-279WP_000578476.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family-
ASZ88_RS18600841081..841365-285WP_000381183.1type II toxin-antitoxin system RelB/DinJ family antitoxin-
ASZ88_RS18605841559..842074+516WP_000343779.1GNAT family N-acetyltransferase-
ASZ88_RS18610842258..842671+414WP_000049420.1VOC family protein-
ASZ88_RS18625843226..844403+1178WP_086010879.1IS3-like element ISVch4 family transposase-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-688711..843534154823
-insideIntegroncatB9-693791..843158149367
flankIS/Tn--836106..836543437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Protein of unknown function DUF2442

(4-59)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T58345 WP_001114075.1 NZ_CP013312:838813-839082 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T58345 NZ_CP013312:838813-839082 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 174 a.a.        Molecular weight: 19409.01 Da        Isoelectric Point: 6.7342

>AT58345 WP_000921691.1 NZ_CP013312:839076-839597 [Vibrio cholerae]
MLKVIDVDFVSDHTLELTFNDGYQGYADLSVYFKKAPFSEIKDFKRFSLTRDGSLNWDGNELTAATLRDITKGSQKSVEL
SFNVQEMEAVIKQASWESMMEGRPDILQAAIRSYVEQFGHGQVIAKAGIKSRTSAYRSLKPETTPNFGTLVQLGHAVIEL
AKDRTVANKEPRI

Download         Length: 522 bp

>AT58345 NZ_CP013312:839076-839597 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A086SLD6

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBQ9KM84

References