58344

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) dhiT-phd/-
Location 838678..839082 Replicon chromosome
Accession NZ_CP013312
Organism Vibrio cholerae strain E1320

Toxin (Protein)


Gene name dhiT Uniprot ID A0A086SLD6
Locus tag ASZ88_RS18570 Protein ID WP_001114075.1
Coordinates 838813..839082 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag ASZ88_RS20900 Protein ID WP_099607150.1
Coordinates 838678..838782 (+) Length 35 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ88_RS18525 834179..835096 + 918 WP_000186333.1 alpha/beta hydrolase -
ASZ88_RS18535 835253..835642 + 390 WP_001081302.1 hypothetical protein -
ASZ88_RS18540 835778..835987 + 210 Protein_855 GNAT family N-acetyltransferase -
ASZ88_RS18545 836106..836543 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
ASZ88_RS18550 836607..836825 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
ASZ88_RS18560 837000..837872 + 873 WP_000254716.1 DUF3800 domain-containing protein -
ASZ88_RS18565 838022..838621 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
ASZ88_RS20900 838678..838782 + 105 WP_099607150.1 acetyltransferase Antitoxin
ASZ88_RS18570 838813..839082 + 270 WP_001114075.1 DUF4160 domain-containing protein Toxin
ASZ88_RS18575 839076..839597 + 522 WP_000921691.1 DUF2442 domain-containing protein -
ASZ88_RS20905 839896..840021 + 126 WP_001905700.1 DUF645 family protein -
ASZ88_RS18590 840272..840667 + 396 WP_001000867.1 hypothetical protein -
ASZ88_RS18595 840806..841084 - 279 WP_000578476.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
ASZ88_RS18600 841081..841365 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
ASZ88_RS18605 841559..842074 + 516 WP_000343779.1 GNAT family N-acetyltransferase -
ASZ88_RS18610 842258..842671 + 414 WP_000049420.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 688711..843534 154823
- inside Integron catB9 - 693791..843158 149367
flank IS/Tn - - 836106..836543 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.94 Da        Isoelectric Point: 6.6303

>T58344 WP_001114075.1 NZ_CP013312:838813-839082 [Vibrio cholerae]
MPEIDALLGLSFCLYFFDNKQHKLPHIHVKYGSYELIIAIETGECLEGYLPNKQRKRAENHILEHREQLMVMWNKAVNGE
NPGKLGDLC

Download         Length: 270 bp

>T58344 NZ_CP013312:838813-839082 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 35 a.a.        Molecular weight: 3991.79 Da        Isoelectric Point: 9.2853

>AT58344 WP_099607150.1 NZ_CP013312:838678-838782 [Vibrio cholerae]
VVSVVVFEFSSMRCQPLRRALYAYRNCLLKDTLL

Download         Length: 105 bp

>AT58344 NZ_CP013312:838678-838782 [Vibrio cholerae]
GTGGTTTCGGTTGTTGTGTTTGAGTTTAGTAGTATGCGCTGCCAGCCCCTTAGGCGGGCGTTATATGCTTATAGGAATTG
TCTCCTAAAGGATACGCTGCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A086SLD6

Antitoxin

Source ID Structure

References