Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 833398..833945 Replicon chromosome
Accession NZ_CP013312
Organism Vibrio cholerae strain E1320

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag ASZ88_RS18520 Protein ID WP_000229317.1
Coordinates 833643..833945 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag ASZ88_RS18515 Protein ID WP_000861987.1
Coordinates 833398..833655 (+) Length 86 a.a.

Genomic Context

ASZ88_RS18465ASZ88_RS18475ASZ88_RS18490ASZ88_RS18495ASZ88_RS18500ASZ88_RS18505ASZ88_RS18510ASZ88_RS18515ASZ88_RS18520ASZ88_RS18525ASZ88_RS18535ASZ88_RS18540ASZ88_RS18545ASZ88_RS18550ASZ88_RS18560ASZ88_RS18565ASZ88_RS20900ASZ88_RS18480ASZ88_RS18485
Location: 828427..828882 (456 bp)
Type: Others
Protein ID: WP_001245327.1
Location: 829204..829356 (153 bp)
Type: Others
Protein ID: WP_001884520.1
Location: 830555..831223 (669 bp)
Type: Others
Protein ID: WP_000043871.1
Location: 831375..831662 (288 bp)
Type: Others
Protein ID: WP_000426470.1
Location: 831803..832174 (372 bp)
Type: Others
Protein ID: WP_001164080.1
Location: 832241..832666 (426 bp)
Type: Others
Protein ID: WP_001882332.1
Location: 832663..833196 (534 bp)
Type: Others
Protein ID: WP_000118351.1
Location: 833398..833655 (258 bp)
Type: Antitoxin
Protein ID: WP_000861987.1
Location: 833643..833945 (303 bp)
Type: Toxin
Protein ID: WP_000229317.1
Location: 834179..835096 (918 bp)
Type: Others
Protein ID: WP_000186333.1
Location: 835253..835642 (390 bp)
Type: Others
Protein ID: WP_001081302.1
Location: 835778..835987 (210 bp)
Type: Others
Protein ID: Protein_855
Location: 836106..836543 (438 bp)
Type: Others
Protein ID: WP_000503169.1
Location: 836607..836825 (219 bp)
Type: Others
Protein ID: WP_071908318.1
Location: 837000..837872 (873 bp)
Type: Others
Protein ID: WP_000254716.1
Location: 838022..838621 (600 bp)
Type: Others
Protein ID: WP_001891245.1
Location: 838678..838782 (105 bp)
Type: Others
Protein ID: WP_099607150.1
Location: 829558..830055 (498 bp)
Type: Others
Protein ID: WP_000982260.1
Location: 830052..830324 (273 bp)
Type: Others
Protein ID: WP_000246253.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ASZ88_RS18465828427..828882+456WP_001245327.1GNAT family N-acetyltransferase-
ASZ88_RS18475829204..829356+153WP_001884520.1DUF645 family protein-
ASZ88_RS18480829558..830055-498WP_000982260.1GNAT family N-acetyltransferase-
ASZ88_RS18485830052..830324-273WP_000246253.1DUF1778 domain-containing protein-
ASZ88_RS18490830555..831223+669WP_000043871.1hypothetical protein-
ASZ88_RS18495831375..831662+288WP_000426470.1hypothetical protein-
ASZ88_RS18500831803..832174+372WP_001164080.1nucleotide pyrophosphohydrolase-
ASZ88_RS18505832241..832666+426WP_001882332.1DUF1778 domain-containing protein-
ASZ88_RS18510832663..833196+534WP_000118351.1GNAT family N-acetyltransferase-
ASZ88_RS18515833398..833655+258WP_000861987.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
ASZ88_RS18520833643..833945+303WP_000229317.1type II toxin-antitoxin system RelE/ParE family toxinToxin
ASZ88_RS18525834179..835096+918WP_000186333.1alpha/beta hydrolase-
ASZ88_RS18535835253..835642+390WP_001081302.1hypothetical protein-
ASZ88_RS18540835778..835987+210Protein_855GNAT family N-acetyltransferase-
ASZ88_RS18545836106..836543+438WP_000503169.1IS200/IS605-like element IS1004 family transposase-
ASZ88_RS18550836607..836825+219WP_071908318.1GNAT family N-acetyltransferase-
ASZ88_RS18560837000..837872+873WP_000254716.1DUF3800 domain-containing protein-
ASZ88_RS18565838022..838621+600WP_001891245.1glutathione S-transferase N-terminal domain-containing protein-
ASZ88_RS20900838678..838782+105WP_099607150.1acetyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic islandcatB9-688711..843534154823
-insideIntegroncatB9-693791..843158149367
flankIS/Tn--836106..836543437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T58343 WP_000229317.1 NZ_CP013312:833643-833945 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T58343 NZ_CP013312:833643-833945 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT58343 WP_000861987.1 NZ_CP013312:833398-833655 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT58343 NZ_CP013312:833398-833655 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ9KM92

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1T4SLM9

References