58343

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-Phd
Location 833398..833945 Replicon chromosome
Accession NZ_CP013312
Organism Vibrio cholerae strain E1320

Toxin (Protein)


Gene name relE Uniprot ID Q9KM92
Locus tag ASZ88_RS18520 Protein ID WP_000229317.1
Coordinates 833643..833945 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q9KM93
Locus tag ASZ88_RS18515 Protein ID WP_000861987.1
Coordinates 833398..833655 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ASZ88_RS18465 828427..828882 + 456 WP_001245327.1 GNAT family N-acetyltransferase -
ASZ88_RS18475 829204..829356 + 153 WP_001884520.1 DUF645 family protein -
ASZ88_RS18480 829558..830055 - 498 WP_000982260.1 GNAT family N-acetyltransferase -
ASZ88_RS18485 830052..830324 - 273 WP_000246253.1 DUF1778 domain-containing protein -
ASZ88_RS18490 830555..831223 + 669 WP_000043871.1 hypothetical protein -
ASZ88_RS18495 831375..831662 + 288 WP_000426470.1 hypothetical protein -
ASZ88_RS18500 831803..832174 + 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
ASZ88_RS18505 832241..832666 + 426 WP_001882332.1 DUF1778 domain-containing protein -
ASZ88_RS18510 832663..833196 + 534 WP_000118351.1 GNAT family N-acetyltransferase -
ASZ88_RS18515 833398..833655 + 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ASZ88_RS18520 833643..833945 + 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ASZ88_RS18525 834179..835096 + 918 WP_000186333.1 alpha/beta hydrolase -
ASZ88_RS18535 835253..835642 + 390 WP_001081302.1 hypothetical protein -
ASZ88_RS18540 835778..835987 + 210 Protein_855 GNAT family N-acetyltransferase -
ASZ88_RS18545 836106..836543 + 438 WP_000503169.1 IS200/IS605-like element IS1004 family transposase -
ASZ88_RS18550 836607..836825 + 219 WP_071908318.1 GNAT family N-acetyltransferase -
ASZ88_RS18560 837000..837872 + 873 WP_000254716.1 DUF3800 domain-containing protein -
ASZ88_RS18565 838022..838621 + 600 WP_001891245.1 glutathione S-transferase N-terminal domain-containing protein -
ASZ88_RS20900 838678..838782 + 105 WP_099607150.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island catB9 - 688711..843534 154823
- inside Integron catB9 - 693791..843158 149367
flank IS/Tn - - 836106..836543 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11726.68 Da        Isoelectric Point: 5.1972

>T58343 WP_000229317.1 NZ_CP013312:833643-833945 [Vibrio cholerae]
MVEIIWTELALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ

Download         Length: 303 bp

>T58343 NZ_CP013312:833643-833945 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCTGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCGCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9647.15 Da        Isoelectric Point: 7.3178

>AT58343 WP_000861987.1 NZ_CP013312:833398-833655 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK

Download         Length: 258 bp

>AT58343 NZ_CP013312:833398-833655 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCCTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9KM92

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SLM9

References